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    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    1.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08828934B2

    公开(公告)日：2014-09-09

    申请号：US13245188

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： A61K38/45 ,  C12N9/12 ,  A61K38/00

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为 与胰腺功能障碍的发生概率相关。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    2.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 失效
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08076098B2

    公开(公告)日：2011-12-13

    申请号：US12174301

    申请日：2008-07-16

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

    摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    3.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08957020B2

    公开(公告)日：2015-02-17

    申请号：US13245113

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC分类号： C12N9/12 ,  A61K38/45 ,  A61K38/00

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括鉴定具有升高的发生或发展肥胖的概率的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定动物或人类受试者是否具有Mnk2和/或Mnk1基因或其同源物的遗传变体，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述 遗传变异与增加或发展肥胖的可能性相关。

    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
    5.
    发明申请
    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM 有权
    Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白

    公开(公告)号：US20120045452A1

    公开(公告)日：2012-02-23

    申请号：US13245188

    申请日：2011-09-26

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Günter Brönner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jäkel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Günter Brönner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jäkel ,  Christoph Meyer

    IPC分类号： A61K31/7088 ,  A61P1/18 ,  G01N33/573 ,  C12Q1/48 ,  C12Q1/68 ,  A61K39/395 ,  A61P3/10

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

    摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为 与胰腺功能障碍的发生概率相关。

    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
    7.
    发明申请
    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM 失效
    Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白

    公开(公告)号：US20090170095A1

    公开(公告)日：2009-07-02

    申请号：US12174301

    申请日：2008-07-16

    申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

    摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。