公开(公告)号：US20090170095A1

公开(公告)日：2009-07-02

申请号：US12174301

申请日：2008-07-16

申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Broenner ,  Thomas Clossek ,  Bettina Rudoplh ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/48

CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

公开(公告)号：US20120045451A1

公开(公告)日：2012-02-23

申请号：US13245113

申请日：2011-09-26

申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

IPC分类号： A61K39/395 ,  G01N33/573 ,  C12Q1/48 ,  A61K48/00 ,  A61P3/04 ,  C12Q1/68 ,  A61K31/7088

CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

摘要： This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

摘要翻译： 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括鉴定具有升高的发生或发展肥胖的概率的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定动物或人类受试者是否具有Mnk2和/或Mnk1基因或其同源物的遗传变体，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述 遗传变异与增加或发展肥胖的可能性相关。

公开(公告)号：US20050080026A1

公开(公告)日：2005-04-14

申请号：US10494010

申请日：2002-10-29

申请人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

发明人： Arnd Steuernagel ,  Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

IPC分类号： A01K67/027 ,  A61K31/519 ,  A61K31/553 ,  A61K38/45 ,  A61K39/395 ,  A61K48/00 ,  A61P1/16 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P19/02 ,  A61P25/18 ,  A61P25/28 ,  A61P35/00 ,  A61P39/06 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12Q1/48 ,  C12R1/91 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C12N9/1205 ,  A61K38/45 ,  Y10S514/909

摘要： The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

摘要翻译： 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

公开(公告)号：US08129164B2

公开(公告)日：2012-03-06

申请号：US13022765

申请日：2011-02-08

申请人： Markus Wahl ,  Ralf Jauch ,  Kay Schreiter ,  Stefan Jakel

发明人： Markus Wahl ,  Ralf Jauch ,  Kay Schreiter ,  Stefan Jakel

IPC分类号： C12N9/12

CPC分类号： C12N9/1205 ,  C07K2299/00 ,  C30B7/00

摘要： The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.

摘要翻译： 本发明涉及结晶Mnk-1和Mnk-2激酶，特别涉及Mnk-1和Mnk-2激酶结构域的晶体结构。

公开(公告)号：US20100143341A1

公开(公告)日：2010-06-10

申请号：US11993433

申请日：2006-06-21

申请人： Steven Taylor ,  Stephen Murfin ,  Thomas Stephen Coulter ,  Stefan Jakel ,  Babette Aicher ,  Arndt-Rene Kelter ,  Joachim Kraemer ,  Christian Kirchhoff ,  Andreas Scheel ,  Julian Woelcke

发明人： Steven Taylor ,  Stephen Murfin ,  Thomas Stephen Coulter ,  Stefan Jakel ,  Babette Aicher ,  Arndt-Rene Kelter ,  Joachim Kraemer ,  Christian Kirchhoff ,  Andreas Scheel ,  Julian Woelcke

IPC分类号： A61K31/519 ,  C07D495/04 ,  A61K31/5377 ,  A61K38/28 ,  A61K31/60 ,  A61K39/395 ,  A61K31/704 ,  A61P3/00

CPC分类号： C07D495/04

摘要： The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

摘要翻译： 本发明涉及包含噻吩并嘧啶化合物的通式（I）的新型药物组合物。 此外，本发明涉及本发明的噻吩并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a）激酶活性的疾病的用途 或Mnk2b）和/或其变体。