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公开(公告)号:US09168310B2
公开(公告)日:2015-10-27
申请号:US14063401
申请日:2013-10-25
申请人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号: A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要: The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
摘要翻译: 本文描述的本发明提供包含非哺乳动物衍生的丝氨酸甘油磷脂缀合物的混合物的制剂,其具有LA,亚麻酸(α-亚麻酸,γ-亚麻酸)DHA和EPA的特定含量和特异性缀合图案,其依赖于使用不同的 脂质来源,以及这些制剂的用途。
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公开(公告)号:US08470345B2
公开(公告)日:2013-06-25
申请号:US12590893
申请日:2009-11-16
申请人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
IPC分类号: A61K31/685 , A61P25/00
CPC分类号: A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要: A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译: 一种包含甘油磷脂或盐的缀合物及其衍生物,特别是磷脂酰丝氨酸(PS),磷脂酰胆碱(PC),磷脂酰乙醇胺(PE),磷脂酰肌醇(PI),磷脂酰甘油(PG)和磷脂酸(PA) - 不饱和脂肪酸(PUFA)酰基,特别是长链多不饱和脂肪酸(LC-PUFA)酰基如ω-3和/或ω-6酰基,其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性,并且可用于治疗各种认知和精神状况和障碍,并用于维持脑相关系统和过程的正常功能。
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公开(公告)号:US20090011075A1
公开(公告)日:2009-01-08
申请号:US11912925
申请日:2006-04-27
申请人: Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人: Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号: A23L1/30
CPC分类号: A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要: Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译: 本文公开了包含甘油磷脂如磷脂酰胆碱(PC),磷脂酰乙醇胺(PE),磷脂酰丝氨酸(PS)和磷脂酰肌醇(PI)以及鞘脂如鞘氨醇(SM)的极性脂质混合物。 最重要的是,所述混合物中磷脂的比例与HMF的比例相当,并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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公开(公告)号:US20080058415A1
公开(公告)日:2008-03-06
申请号:US10576239
申请日:2004-10-21
申请人: Avidor Shulman , Gai Ben Dror , Dori Pelled
发明人: Avidor Shulman , Gai Ben Dror , Dori Pelled
CPC分类号: A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要: Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically synthesized synthetic oil, particularly glyceride-based lipid with high levels of mono- or polyunsaturated fatty acids at positions sn-1 and sn-3 of the glycerol backbone, vegetable- and plant-derived oil, such as flax and canola oils, short and medium chains lipid, preferably MCT and an oil mimicking the triglyceride composition of human mother's milk fat and its various uses.The dietary ingredient is particularly intended for use in enhancing calcium absorption and in the prevention and/or treatment of disorders associated with depletion of bone calcium and bone density, prevention and treatment of osteoporosis, for the enhancement of bone formation and bone mass maximization and for the enhancement of bone formation in infants and young children.
摘要翻译: 公开了包含至少一种不抑制矿物质吸收的可食用脂质,增强矿物质吸收和摄入的膳食成分,特别是化学或酶合成的合成油,特别是甘油酯类脂质,其具有高水平的单不饱和脂肪酸或多不饱和脂肪酸 甘油骨架的sn-1和sn-3,植物和植物来源的油,例如亚麻和低芥酸菜子油,短链和中链脂质,优选MCT和模仿人母乳脂肪的甘油三酯组合物的油及其各种 用途。 膳食成分特别用于增强钙的吸收,以及预防和/或治疗与骨钙素和骨密度消耗相关的疾病,预防和治疗骨质疏松症,用于增强骨形成和骨量最大化以及 增强婴幼儿骨骼形成。
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公开(公告)号:US20160015820A1
公开(公告)日:2016-01-21
申请号:US14871260
申请日:2015-09-30
申请人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号: A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要: The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
摘要翻译: 本文描述的本发明提供包含非哺乳动物衍生的丝氨酸甘油磷脂缀合物的混合物的制剂,其具有LA,亚麻酸(α-亚麻酸,γ-亚麻酸)DHA和EPA的特定含量和特异性缀合图案,其依赖于使用不同的 脂质来源,以及这些制剂的用途。
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公开(公告)号:US08618050B2
公开(公告)日:2013-12-31
申请号:US10576239
申请日:2004-10-21
申请人: Avidor Shulman , Gai Ben Dror , Dori Pelled
发明人: Avidor Shulman , Gai Ben Dror , Dori Pelled
IPC分类号: A61K38/00
CPC分类号: A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要: Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically synthesized synthetic oil, particularly glyceride-based lipid with high levels of mono- or polyunsaturated fatty acids at positions sn-1 and sn-3 of the glycerol backbone, vegetable- and plant-derived oil, such as flax and canola oils, short and medium chains lipid, preferably MCT and an oil mimicking the triglyceride composition of human mother's milk fat and its various uses.The dietary ingredient is particularly intended for use in enhancing calcium absorption and in the prevention and/or treatment of disorders associated with depletion of bone calcium and bone density, prevention and treatment of osteoporosis, for the enhancement of bone formation and bone mass maximization and for the enhancement of bone formation in infants and young children.
摘要翻译: 公开了包含至少一种不抑制矿物质吸收的可食用脂质,增强矿物质吸收和摄入的膳食成分,特别是化学或酶合成的合成油,特别是甘油酯类脂质,其具有高水平的单不饱和脂肪酸或多不饱和脂肪酸 甘油骨架的sn-1和sn-3,植物和植物来源的油,例如亚麻和低芥酸菜子油,短链和中链脂质,优选MCT和模仿人母乳脂肪的甘油三酯组合物的油及其各种 用途。 膳食成分特别用于增强钙的吸收,以及预防和/或治疗与骨钙素和骨密度消耗相关的疾病,预防和治疗骨质疏松症,用于增强骨形成和骨量最大化以及 增强婴幼儿骨骼形成。
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公开(公告)号:US07968112B2
公开(公告)日:2011-06-28
申请号:US11872440
申请日:2007-10-15
申请人: Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人: Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
CPC分类号: A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要: A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidyicholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译: 包括甘油磷脂或盐的缀合物及其衍生物,特别是磷脂酰丝氨酸(PS),磷脂酰胆碱(PC),磷脂酰乙醇胺(PE),磷脂酰肌醇(PI),磷脂酰甘油(PG)和磷脂酸(PA) - 不饱和脂肪酸(PUFA)酰基,特别是长链多不饱和脂肪酸(LC-PUFA)酰基如ω-3和/或ω-6酰基,其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性,并且可用于治疗各种认知和精神状况和障碍,并用于维持脑相关系统和过程的正常功能。
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8.
公开(公告)号:US20060233863A1
公开(公告)日:2006-10-19
申请号:US11396257
申请日:2006-03-31
申请人: Dorit Platt , Dori Pelled , Avidor Shulman , Gai Ben-Dror
发明人: Dorit Platt , Dori Pelled , Avidor Shulman , Gai Ben-Dror
CPC分类号: A61K31/22 , A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K45/06 , A61K2300/00 , A23V2250/182 , A23V2250/2136
摘要: Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
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公开(公告)号:US09814252B2
公开(公告)日:2017-11-14
申请号:US13205071
申请日:2011-08-08
申请人: Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人: Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号: A23J7/00 , A23L33/115
CPC分类号: A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要: Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
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公开(公告)号:US08568773B2
公开(公告)日:2013-10-29
申请号:US12934338
申请日:2009-06-24
申请人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人: Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号: A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要: The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
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