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    Lipids containing omega-3 and omega-6 fatty acids
    5.
    发明申请
    Lipids containing omega-3 and omega-6 fatty acids 有权
    含有ω-3和ω-6脂肪酸的脂质

    公开(公告)号：US20100069332A1

    公开(公告)日：2010-03-18

    申请号：US12590893

    申请日：2009-11-16

    申请人： Gai BEN DROR ,  Dorit PLATT ,  Orly FARKASH ,  Rassan ZUABI ,  Zohar BAR-ON ,  Avidor SHULMAN ,  Dori PELLED

    发明人： Gai BEN DROR ,  Dorit PLATT ,  Orly FARKASH ,  Rassan ZUABI ,  Zohar BAR-ON ,  Avidor SHULMAN ,  Dori PELLED

    IPC分类号： A61K31/685 ,  A61P25/00

    CPC分类号： A61K31/685 ,  A21D2/32 ,  A23D7/013 ,  A23D9/013 ,  A23L33/12 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/1882 ,  A23V2250/1942 ,  A23V2250/1842

    摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.

    摘要翻译： 一种包含甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。

    Glycerophospholipids for the improvement of cognitive functions
    6.
    发明申请
    Glycerophospholipids for the improvement of cognitive functions 有权
    甘油磷脂用于提高认知功能

    公开(公告)号：US20090074857A1

    公开(公告)日：2009-03-19

    申请号：US12215080

    申请日：2008-06-24

    申请人： Gai Ben Dror ,  Dorit Platt ,  Orly Farkash ,  Rassan Zuabi ,  Zohar Bar-On ,  Avidor Shulman ,  Dori Pelled ,  Yael Richter

    发明人： Gai Ben Dror ,  Dorit Platt ,  Orly Farkash ,  Rassan Zuabi ,  Zohar Bar-On ,  Avidor Shulman ,  Dori Pelled ,  Yael Richter

    IPC分类号： A61K9/48 ,  A61K31/66 ,  A61P25/00

    CPC分类号： A61K47/544 ,  A21D2/32 ,  A23D7/013 ,  A23D9/013 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/201 ,  A61K31/202 ,  A61K31/66 ,  A61K31/685 ,  C07F9/10 ,  A23V2200/322 ,  A23V2250/1882 ,  A23V2250/1942 ,  A23V2250/1842

    摘要： Disclosed herein are alternative, enhanced, and cheaper methods of improving cognitive functions in a subject using a lipid composition conjugated with omega-3 and omega-6 fatty acids, with specific amounts and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and eicosapentaenoyl (EPA), e.g. utilizing different sources of lipids.Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease.The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.

    摘要翻译： 本文公开的是使用与ω-3和ω-6脂肪酸缀合的脂质组合来改善受试者的认知功能的替代的，增强的和更便宜的方法，具有LA，亚麻酸（α-亚麻酸）的特定量和特异性共轭模式 ，γ-亚麻酸）DHA和二十碳五烯酰（EPA），例如 利用不同的脂质来源。 本文公开了一种脂质制剂，所述制剂包含磷脂酰丝氨酸部分和多不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基，例如ω-3和/或 ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 所述脂质制剂特别可用于治疗精神和认知障碍，例如， ADHD（注意缺陷多动障碍）和阿尔茨海默病。 所公开的制剂提供了改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，以及维持脑相关系统和过程的正常功能。

    MIXTURE CONTAINING FATTY ACID GLYCERIDES
    7.
    发明申请
    MIXTURE CONTAINING FATTY ACID GLYCERIDES 审中-公开
    含有脂肪酸甘油的混合物

    公开(公告)号：US20080248187A1

    公开(公告)日：2008-10-09

    申请号：US12061276

    申请日：2008-04-02

    申请人： Ulrich Schoerken ,  Peter Kempers ,  Andreas Sander ,  Peter Horlacher

    发明人： Ulrich Schoerken ,  Peter Kempers ,  Andreas Sander ,  Peter Horlacher

    IPC分类号： A23L1/29 ,  C12P7/64 ,  C07C55/00

    CPC分类号： C12P7/6454 ,  A23D9/013 ,  A23D9/02 ,  A23K20/158 ,  A23K50/80 ,  A23L33/12 ,  A23V2002/00 ,  C11C3/003 ,  C11C3/10 ,  A23V2200/30 ,  A23V2250/182 ,  A23V2250/1942 ,  A23V2250/192

    摘要： A mixture containing fatty acid glycerides which has a high percentage content of PUFA acyl groups and a low percentage content of saturated fatty acid acyl groups is described. A process which enables the PUFA acyl groups in a mixture containing fatty acid glycerides (for example a fish oil) to be enriched and, at the same time, the content of saturated fatty acid acyl groups to be maintained at a low content is described. The process is a hydrolytic process or an alcoholysis in which the fatty acid acyl groups to be enriched are hydrolytically or alcoholytically released from the fatty acid glycerides slowly, if at all, the process being carried out in the presence of a lipase.

    摘要翻译： 描述了包含脂肪酸甘油酯的混合物，其具有高百分比含量的PUFA酰基和低百分含量的饱和脂肪酸酰基。 描述了使包含脂肪酸甘油酯（例如鱼油）的混合物中的PUFA酰基富集并且同时使饱和脂肪酸酰基含量维持在低含量的方法。 该方法是水解方法或醇解，其中待富集的脂肪酸酰基缓慢地从脂肪酸甘油酯水解或醇解地释放，如果完全是在脂肪酶存在下进行的。