Abstract:
A process for the preparation of microcapsules including (a) preparation of an aqueous biphasic system by mixing (i) component (a1) including a component A selected from polyethylene glycol vinyl acetate comb polymers, polycarboxylates, polyethers, polyaspartates, polyvinylpyrrolidone, polyamines, and polylysine; wherein component (a1) is a monophasic system at 23° C., and forms a monophasic system at 23° C. if mixed with water in the range of from 1:99 to 99:1 by weight, and (ii) component (a2) containing water and a water-soluble component B, wherein water-soluble component B is different from component A, and wherein (a2) is a monophasic system at 23° C., (iii) at least one monomer (a3), and (iv) optionally at least one initiator (a4), wherein (a1), (a2), (a3), and (a4) can be mixed together in any order or simultaneously, followed by (b) optionally shearing of the biphasic system to form an emulsion, and (c) polymerization of monomer (a3).
Abstract:
Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.
Abstract:
The present invention relates to novel enzyme particles comprising a core and a coating, wherein the core comprises at least one enzyme and the coating comprises at least one organic white pigment and uses thereof.
Abstract:
The present invention relates to microcapsules comprising at least one polyethervinyl ester graftpolymer, at least one acrylic polymer, and water in the range of from 0.1% of weight to 0% of weight of the total polymer as well as to processes preparing the same.
Abstract:
Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.
Abstract:
Described herein is an enzyme preparation including Component (a): at least one compound according to general formula (I) wherein R1 is H; R2, R3, R4 are independently from each other selected from the group consisting of H, linear C1-C8 alkyl, and branched C3-C8 alkyl, C6-C10-aryl, non-substituted or substituted with one or more carboxylate or hydroxyl groups, and C6-C10-aryl-alkyl, wherein an alkyl of the C6-C10-aryl-alkyl is selected from the group consisting of linear C1-C8 alkyl and branched C3-C8 alkyl, wherein at least one of R2, R3, and R4 is not H, component (b): at least one enzyme selected from the group consisting of hydrolases (EC 3) and proteases component (c): at least one compound selected from the group consisting of solvents, enzyme stabilizers different from component (a), and compounds stabilizing the enzyme preparation.
Abstract:
The present invention relates to a computer-implemented method for activity based enzyme formulation management of an enzyme formulation comprising (i) receiving input data, preferably via an input unit (10), of at least one storage segment data defined by at least temperature and storage duration and an initial enzyme activity value of said enzyme Predicted degradation formulation; (ii) determining, specifically calculating, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value via a processing unit (20); (iii) providing a remaining activity value for the enzyme formulation, preferably via an output unit (30), and (iv) managing said enzyme formulation based on the remaining activity value of step (iii), said managing preferably comprising at least one of—providing a dosage recommendation based on the remaining activity value of the enzyme formulation, preferably via an output unit (30);—providing a residual shelf life indicator for said enzyme formulation based on the remaining activity value of the enzyme formulation; —automated adjustment of a dosage of the enzyme formulation by controlling of a dosing equipment; and/or—eliciting an order of a batch of enzyme formulation if the remaining activity value is indicative of the total enzyme activity in the enzyme formulation being below a pre- determined threshold value. The present invention also relates to an apparatus for activity based enzyme formulation management of an enzyme formulation, comprising: —an input unit (10) configured to receive a data input, preferably a user interface, wherein the data input comprises storage segment data defined by at least temperature and duration and an initial enzyme activity value of said enzyme formulation; —a processing unit (20), preferably a processing unit comprising at least one processor, configured, specifically by programming, to determine, specifically to calculate, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value; and—an output unit (30) configured to output the remaining activity value for the enzyme formulation to the user and/or to a data interface.; and to a system comprising said apparatus. The present invention further relates to methods, computer programs, data carriers, and uses related to the aforesaid method, apparatus, and system.