-
公开(公告)号：US09944666B2
公开(公告)日：2018-04-17
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07D401/04 , C07D215/38 , C07D217/12 , A61K31/47 , C07F7/08 , A61K45/06 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D451/14
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
-
公开(公告)号：US20170158687A1
公开(公告)日：2017-06-08
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D401/06 , A61K45/06 , A61K31/4725 , C07D217/22 , A61K31/472
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
-
公开(公告)号：US09771326B2
公开(公告)日：2017-09-26
申请号：US14443944
申请日：2013-11-20
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lihong Sun , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/62 , C07D401/10 , C07D237/14 , C07D215/14 , C07D401/04 , C07D239/34 , C07D417/04 , C07D417/06 , C07C229/14 , C07D249/06 , C07C229/48 , C07C229/50 , C07D487/04 , C07D205/04 , C07D207/16 , C07D277/28 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06
CPC classification number: C07D211/62 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06 , C07B2200/07 , C07C229/14 , C07C229/48 , C07C229/50 , C07C2601/14 , C07C2602/44 , C07D205/04 , C07D207/16 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , C07D215/14 , C07D237/14 , C07D239/34 , C07D249/06 , C07D277/28 , C07D401/04 , C07D401/10 , C07D417/04 , C07D417/06 , C07D487/04
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
-
公开(公告)号：US20170174710A1
公开(公告)日：2017-06-22
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D215/38 , C07D451/14 , A61K45/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
-
公开(公告)号：US09522889B2
公开(公告)日：2016-12-20
申请号：US14417300
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/44 , A61K31/4375 , C07D295/096 , C07D223/06 , A61K45/06 , C07D217/22 , C07D471/08 , C07D211/34 , C07D211/62 , C07C255/59 , C07C229/46 , C07C229/48 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/5375 , A61K31/55 , C07C217/22 , C07D209/52 , C07D221/22
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
-
Patent Agency Ranking
公开(公告)号：US20160039825A1
公开(公告)日：2016-02-11
申请号：US14772481
申请日：2014-03-14
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lei Zhang , Lihong Sun , Gnanasambandam Kumaravel , Art Taveras , Deping Wang
IPC: C07D487/04 , C07D519/00
CPC classification number: A61K31/198 , A61K36/9068 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
-
公开(公告)号：US10144732B2
公开(公告)日：2018-12-04
申请号：US15316534
申请日：2015-06-05
Applicant: BIOGEN MA INC.
Inventor： Gnanasambandam Kumaravel , Hairuo Peng , Zhili Xin
IPC: C07D471/04 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
-
公开(公告)号：US20170197960A1
公开(公告)日：2017-07-13
申请号：US15316534
申请日：2015-06-05
Applicant: BIOGEN MA INC.
Inventor： Gnanasambandam Kumaravel , Hairuo Peng , Zhili Xin
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
-
公开(公告)号：US10017506B2
公开(公告)日：2018-07-10
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/4375 , A61K31/44 , C07D451/02 , C07D217/22 , A61K31/472 , A61K45/06 , A61K31/4725 , C07D401/06
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
-
公开(公告)号：US09765016B2
公开(公告)日：2017-09-19
申请号：US14763893
申请日：2014-01-29
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Xiaogao Liu , Bin Ma , Hairuo Peng
IPC: C07C229/14 , C07C229/48 , C07C229/50 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/695 , A61K45/06 , C07F7/08
CPC classification number: C07C229/14 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/695 , A61K45/06 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/26 , C07C2602/44 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07F7/0812 , Y02A50/401
Abstract: Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.03 seconds)
