公开(公告)号：US20210163430A1

公开(公告)日：2021-06-03

申请号：US17045069

申请日：2019-04-02

Applicant: Bayer Aktiengesellschaft ,  Bayer CropScience Aktiengesellschaft

Inventor： Taraneh FARIDA ,  Martin LITTMANN ,  Ali SANLI ,  Kyra Larissa PABST ,  Juergen LUDWIG ,  Albert SCHNATTERER

IPC: C07D275/03

Abstract: The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

公开(公告)号：US20160107986A1

公开(公告)日：2016-04-21

申请号：US14892114

申请日：2014-05-20

Applicant: BAYER CROPSCIENCE Aktiengesellschaft

Inventor： Albert SCHNATTERER ,  Dieter HEINZ ,  Martin LITTMANN ,  Ulrich PHILIPP ,  Juergen LUDWIG ,  Constantin FRERICK ,  Michael BARZ

IPC: C07C249/08 ,  C07F9/09

CPC classification number: C07C249/08 ,  C07F9/09 ,  C07C251/48 ,  C07C251/36 ,  C07C251/44

Abstract: Method for preparing certain oximes and oxime O-methyl ethers by reacting poorly water-soluble carbonyl compounds with salts of hydroxylamine or hydroxylamine O-methyl ether or the free base of hydroxylamine in the presence of certain phosphoric esters or salts thereof of the formula (I) wherein R1, R2 and X are defined as specified in the description.

Abstract translation: 通过使难溶于水的羰基化合物与羟胺或羟胺的盐O-甲基醚或羟胺的游离碱在式（I）的某些磷酸酯或其盐存在下反应来制备某些肟和肟O-甲基醚的方法 ）其中R1，R2和X如说明书中所述定义。

公开(公告)号：US20190144385A1

公开(公告)日：2019-05-16

申请号：US16098138

申请日：2017-04-26

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Taraneh FARIDA ,  Martin LITTMANN ,  Rafael WARSITZ ,  Michael ESSER ,  Albert SCHNATTERER

IPC: C07D207/38 ,  C07D201/08

CPC classification number: C07D207/38 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.

公开(公告)号：US20170081284A1

公开(公告)日：2017-03-23

申请号：US15126593

申请日：2015-03-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Guenter SCHLEGEL ,  Albert SCHNATTERER

IPC: C07D213/38

CPC classification number: C07D213/38 ,  C07D213/61

Abstract: A process for preparing N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine of formula (III) wherein 2,2-difluoroethylamine of formula (I) is reacted with a halide of formula (II) in the presence of a hydroxide of an alkali metal or alkaline earth metal.

公开(公告)号：US20200039937A1

公开(公告)日：2020-02-06

申请号：US16471132

申请日：2017-12-12

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Wahed Ahmed MORADI ,  Albert SCHNATTERER ,  Dietmar BIELEFELDT ,  Rolf GERTZMANN ,  Dirk HAVEKOST

IPC: C07D213/61

Abstract: Described is a process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof

公开(公告)号：US20180297952A1

公开(公告)日：2018-10-18

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Günter SCHLEGEL ,  Albert SCHNATTERER ,  Frank VOLZ

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US20160280648A1

公开(公告)日：2016-09-29

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Thomas HIMMLER ,  Thomas Norbert MUELLER ,  Albert SCHNATTERER ,  Guenter SCHLEGEL

IPC: C07D213/56

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluorometyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluorometyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

Abstract translation: 本发明涉及取代的2-甲基氰基吡啶衍生物，特别是3-氯-5-（三氟甲基）吡啶-2-基]乙腈[= Py-CN]到取代的2-乙基氨基吡啶衍生物的催化氢化，特别是 2- [3-氯-5-（三氟甲基）吡啶-2-基]乙胺[= Py-乙胺]或其盐在金属催化剂，特别是钯催化剂存在下。