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公开(公告)号：US20210209752A1
公开(公告)日：2021-07-08
申请号：US17103414
申请日：2020-11-24
Applicant: BERKELEY LIGHTS, INC.
Inventor： John A. TENNEY , Thomas M. VETTERLI , Hansohl E. KIM
Abstract: Methods are provided for the automated detection, characterization, and selection of micro-objects in a microfluidic device. In addition, methods are provided for grouping detected micro-objects into subgroups that share the same characteristics and, optionally, repositioning micro-objects in a selected sub-population within the microfluidic device. For example, micro-objects in a selected sub-population can be moved into sequestration pens. The methods also provide for visual displays of the micro-object characteristics, such as two- or three-dimensional graphs, and for user-based definition and/or selection of sub-populations of the detected micro-objects. In addition, non-transitory computer-readable medium in which a program is stored and systems for carrying out any of the disclosed methods are provided.
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公开(公告)号：US20210349075A1
公开(公告)日：2021-11-11
申请号：US17241865
申请日：2021-04-27
Applicant: BERKELEY LIGHTS, INC.
Inventor： Yelena BRONEVETSKY , Annamaria MOCCIARO , Guido K. STADLER , Peter J. BEEMILLER , Natalie C. MARKS , Duane SMITH , Vincent Haw Tien PAI , Jason M. MCEWEN , Amanda L. GOODSELL , John A. TENNEY , Thomas M. VETTERLI , Hansohl E. Kim
Abstract: Methods are provided for the assay of secreted biomolecules using automated detection and characterization of micro-objects in a microfluidic device. The biomolecules can be secreted by cells, particularly immunological cells, such as T cells. The biomolecules being assayed can include cytokines, growth factors, and the like. Methods are also provided for assaying the cytotoxicity of a cell with respect to another, target cell. Also provided are kits and non-transitory computer-readable media in which programs are stored for causing a system comprising a computer to perform automated methods for detecting secreted biomolecules and/or cytotoxicity in a microfluidic device.
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Patent Agency Ranking
公开(公告)号：US20220130158A1
公开(公告)日：2022-04-28
申请号：US17495728
申请日：2021-10-06
Applicant: Berkeley Lights, Inc.
Inventor： Hansohl E. KIM , John A. TENNEY , Joshua F. SLOCUM
Abstract: Methods are provided for the automated detection and/or counting of micro-objects in a microfluidic device. In addition, methods are provided for repositioning micro-objects in a microfluidic device. In addition, methods are provided for separating micro-objects in a spatial region of the microfluidic device.
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公开(公告)号：US20220250071A1
公开(公告)日：2022-08-11
申请号：US17534350
申请日：2021-11-23
Applicant: Berkeley Lights, Inc.
Inventor： Troy A. LIONBERGER , Matthew E. FOWLER , Phillip J. M. ELMS , Kevin D. LOUTHERBACK , Randall D. LOWE, JR. , Jian GONG , J. Tanner NEVILL , Gang F. WANG , Gregory G. LAVIEU , John A. TENNEY , Aathavan KARUNAKARAN , Anupam SINGHAL , I-Jong LIN
Abstract: Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object.
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公开(公告)号：US20190240665A1
公开(公告)日：2019-08-08
申请号：US16160816
申请日：2018-10-15
Applicant: Berkeley Lights, Inc.
Inventor： Troy A. LIONBERGER , Matthew E. FOWLER , Phillip J. M. ELMS , Kevin D. LOUTHERBACK , Randall D. LOWE, JR. , Jian GONG , Tanner J. NEVILL , Gang F. WANG , Gregory G. LAVIEU , John A. TENNEY , Aathavan KARUNAKARAN
CPC classification number: B01L3/502761 , B01L9/527 , B01L2300/0829 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N21/05 , G01N21/6452 , G01N21/6458 , G01N2201/0675 , G06T7/0014
Abstract: Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object.
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公开(公告)号：US20250046058A1
公开(公告)日：2025-02-06
申请号：US18659001
申请日：2024-05-09
Applicant: Berkeley Lights, Inc.
Inventor： Hansohl E. KIM , John A. TENNEY , Joshua F. SLOCUM
IPC: G06V10/764 , G06F18/214 , G06F18/24 , G06T1/00 , G06T5/20 , G06T7/246 , G06T7/73 , G06V10/82 , G06V20/69
Abstract: Methods are provided for the automated detection and/or counting of micro-objects in a microfluidic device. In addition, methods are provided for repositioning micro-objects in a microfluidic device. In addition, methods are provided for separating micro-objects in a spatial region of the microfluidic device.
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公开(公告)号：US20190384963A1
公开(公告)日：2019-12-19
申请号：US16428792
申请日：2019-05-31
Applicant: Berkeley Lights, Inc.
Inventor： Hansohl E. KIM , John A. TENNEY , Joshua F. SLOCUM
Abstract: Methods are provided for the automated detection and/or counting of micro-objects in a microfluidic device. In addition, methods are provided for repositioning micro-objects in a microfluidic device. In addition, methods are provided for separating micro-objects in a spatial region of the microfluidic device.
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