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公开(公告)号：US20220250071A1
公开(公告)日：2022-08-11
申请号：US17534350
申请日：2021-11-23
Applicant: Berkeley Lights, Inc.
Inventor： Troy A. LIONBERGER , Matthew E. FOWLER , Phillip J. M. ELMS , Kevin D. LOUTHERBACK , Randall D. LOWE, JR. , Jian GONG , J. Tanner NEVILL , Gang F. WANG , Gregory G. LAVIEU , John A. TENNEY , Aathavan KARUNAKARAN , Anupam SINGHAL , I-Jong LIN
Abstract: Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object.
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Patent Agency Ranking
公开(公告)号：US20220356429A1
公开(公告)日：2022-11-10
申请号：US17743318
申请日：2022-05-12
Applicant: Berkeley Lights, Inc.
Inventor： Randall D. LOWE, JR. , Kristin G. BEAUMONT , Aathavan KARUNAKARAN , Natalie C. MARKS , Jason M. MCEWEN , Mark P. WHITE , J. Tanner NEVILL , Gang F. WANG , Andrew W. MCFARLAND , Daniele Malleo , Keith J. BREINLINGER , Xiao GUAN , Kevin T. CHAPMAN
Abstract: Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof. In some embodiments, culturing a single cell may produce a clonal population in the microfluidic device.
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公开(公告)号：US20170114316A1
公开(公告)日：2017-04-27
申请号：US15282923
申请日：2016-09-30
Applicant: Berkeley Lights, Inc.
Inventor： Russell A. NEWSTROM , Andrew W. MCFARLAND , Darcy K. KELLY-GREENE , J. Tanner NEVILL , Gang F. WANG
CPC classification number: C12M41/14 , C12M23/12 , C12M23/38 , C12M23/46 , C12M37/04 , C12M41/22 , C12M41/32 , C12M41/34 , C12M41/48
Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.
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公开(公告)号：US20230242860A1
公开(公告)日：2023-08-03
申请号：US17936478
申请日：2022-09-29
Applicant: Berkeley Lights, Inc.
Inventor： Russell A. NEWSTROM , Andrew W. MCFARLAND , Darcy K. KELLY-GREENE , J. Tanner NEVILL , Gang F. WANG
CPC classification number: C12M41/14 , C12M23/12 , C12M23/38 , C12M23/46 , C12M37/04 , C12M41/22 , C12M41/32 , C12M41/34 , C12M41/48
Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.
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公开(公告)号：US20210071124A1
公开(公告)日：2021-03-11
申请号：US16920365
申请日：2020-07-02
Applicant: Berkeley Lights, Inc.
Inventor： Randall D. LOWE, JR. , Kristin G. BEAUMONT , Aathavan KARUNAKARAN , Natalie C. MARKS , Jason M. MCEWEN , Mark P. WHITE , J. Tanner NEVILL , Gang F. WANG , Andrew W. MCFARLAND , Daniele Malleo , Keith J. BREINLINGER , Xiao GUAN , Kevin T. CHAPMAN
Abstract: Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof. In some embodiments, culturing a single cell may produce a clonal population in the microfluidic device.
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6.发明申请DEP FORCE CONTROL AND ELECTROWETTING CONTROL IN DIFFERENT SECTIONS OF THE SAME MICROFLUIDIC APPARATUS 审中-公开相同微流体设备的不同部分的强制控制和电磁控制公开(公告)号：US20170043343A1
公开(公告)日：2017-02-16
申请号：US15306355
申请日：2015-04-25
Applicant: BERKELEY LIGHTS, INC.
Inventor： Igor Y. KHANDROS , J. Tanner NEVILL , Steven W. SHORT , Ming C. WU
CPC classification number: B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0424 , B01L2400/0427 , B03C5/005 , B03C5/026 , B03C2201/26 , C12M23/16 , C12M23/20 , C12M25/16 , C12M27/00 , C12M35/02
Abstract: A microfluidic apparatus can comprise a dielectrophoresis (DEP) configured section for holding a first liquid medium and selectively inducing net DEP forces in the first liquid medium. The microfluidic apparatus can also comprise an electrowetting (EW) configured section for holding a second liquid medium on an electrowetting surface and selectively changing an effective wetting property of the electrowetting surface. The DEP configured section can be utilized to select and move a micro-object in the first liquid medium. The EW configured section can be utilized to pull a droplet of the first liquid medium into the second liquid medium.
Abstract translation: 微流体装置可以包括用于保持第一液体介质并在第一液体介质中选择性地诱导净DEP力的介电电泳（DEP）构造的部分。 微流体装置还可以包括电润湿（EW）构造的部分，用于将第二液体介质保持在电润湿表面上并且选择性地改变电润湿表面的有效润湿性质。 DEP配置部分可用于选择和移动第一液体介质中的微物体。 EW配置部分可用于将第一液体介质的液滴拉入第二液体介质。
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