公开(公告)号：US20230086701A1

公开(公告)日：2023-03-23

申请号：US17946555

申请日：2022-09-16

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Stephen SWIHART ,  Kevin McDONALD

IPC: G01N21/64 ,  G06T5/50 ,  G06V10/60 ,  G01N21/76 ,  G01N33/68

Abstract: Aspects of the present disclosure relate to systems and methods for generating a composite image. This can include a western blot imager with a real time camera. One aspect of the present disclosure relates to an imaging system. The imaging system includes a sample plane that can receive and hold a sample, a photon resolving camera, and a lens attached to the photon resolving camera, the photon resolving camera and the lens positioned to image the sample plane.

公开(公告)号：US20230199130A1

公开(公告)日：2023-06-22

申请号：US18082330

申请日：2022-12-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Stephen SWIHART ,  Evan THRUSH ,  Carl MARLOWE ,  Kenneth OH ,  Michael GRIFFIN

IPC: H04N1/10 ,  H04N1/028 ,  G06T5/50 ,  G06V10/141

CPC classification number: H04N1/1008 ,  H04N1/02865 ,  G06T5/50 ,  G06V10/141 ,  G06T2207/20221

Abstract: Systems and methods for contact imaging of stands with illumination are disclosed herein. A contact imaging system can include a contact imager. The contact imager can include a housing having a base and a lid. The lid can have a closed position against the base and an open position. The contact imager can include a contact area image sensor. The lid can shield the contact area image sensor from ambient light when the lid is in the closed position. The contact imager can include an illuminator that can illuminate at least a portion of a blot on the contact area image sensor when the lid is in the closed position.

公开(公告)号：US20240302641A1

公开(公告)日：2024-09-12

申请号：US18597463

申请日：2024-03-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Stephen SWIHART

IPC: G02B21/36 ,  G02B21/08

CPC classification number: G02B21/361 ,  G02B21/086

Abstract: The present relates to chromatic focusing via filter thickness tuning. Chromatic focusing can be achieved via an imaging system that includes a sample holding plane, a light source that illuminates the sample on the plane, and an imager that captures an image of the sample on the plane. The imager includes a sensor, a lens, and a filter wheel defining a plurality of filter apertures including a first aperture containing a first filter passing light of a first color and having a first focal point shift, and a second aperture containing a second filter passing light of a second color and having a second focal point shift. The focal point shifts cause both light of the first color passing through the first filter and through the lens and light of the second color passing through the second filter and through the lens to focus on the sensor.

公开(公告)号：US20240302323A1

公开(公告)日：2024-09-12

申请号：US18594870

申请日：2024-03-04

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Kevin McDONALD ,  Evan THRUSH ,  Stephen SWIHART

IPC: G01N27/447 ,  H04N23/56

CPC classification number: G01N27/44721 ,  G01N27/44739 ,  H04N23/56

Abstract: Systems, methods, and devices for imaging of stain-free fluorescence on western blot membranes with excitation by epi illumination with UV LEDs are disclosed herein. A method can include collecting and preparing a sample, separating the sample via gel electrophoresis in a gel block, transferring the separated sample from the gel block to an analysis block, generating an image of the sample with an imager, and evaluating the image of the sample. The imager can include a plane to receive and hold a block containing a sample and including a first side and a second side, a camera to image a sample on the plane and positioned above the first side of the plane, and an LED light source positioned above the first side of the plane. The LED light source can illuminate the sample on the plane via epi-illumination, and emits light having a wavelength in a range from approximately 325 nm to approximately 400 nm.