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公开(公告)号：US20210207133A1
公开(公告)日：2021-07-08
申请号：US17211595
申请日：2021-03-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song GONG , Yan WANG
Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
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公开(公告)号：US20180030423A1
公开(公告)日：2018-02-01
申请号：US15632733
申请日：2017-06-26
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Peter B. VANDER HORN , Yan WANG
IPC: C12N9/12
CPC classification number: C12N9/1252 , C07K2319/00 , C12N9/1241 , C12Y207/07007
Abstract: The invention provides novel compositions with polymerase activity and methods of using the compositions.
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公开(公告)号：US20170159132A1
公开(公告)日：2017-06-08
申请号：US15411855
申请日：2017-01-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steven T. OKINO , Yan WANG
IPC: C12Q1/68
Abstract: This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.
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公开(公告)号：US20190078066A1
公开(公告)日：2019-03-14
申请号：US16101895
申请日：2018-08-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yan WANG
Abstract: This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.
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Patent Agency Ranking
公开(公告)号：US20200277579A1
公开(公告)日：2020-09-03
申请号：US16788660
申请日：2020-02-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Peter B. VANDER HORN , Yan WANG
IPC: C12N9/12
Abstract: The invention provides novel compositions with polymerase activity and methods of using the compositions.
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公开(公告)号：US20180127732A1
公开(公告)日：2018-05-10
申请号：US15801114
申请日：2017-11-01
Applicant: Bio-Rad Laboratories, Inc.
CPC classification number: C12N9/1252 , C07K2319/80 , C12N9/22 , C12Q1/686
Abstract: Fusion polypeptides having a heterologous 5′-3′ exonuclease domain linked to a polymerase that does not naturally have 5′-3′ exonuclease activity, as well as methods of their use are provided. Other aspects are also disclosed.
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公开(公告)号：US20230332142A1
公开(公告)日：2023-10-19
申请号：US18125661
申请日：2023-03-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song GONG , Yan WANG
CPC classification number: C12N15/1096 , C12N9/22 , C12Q1/686 , C12N2770/00022 , C12Q1/6844
Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
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8.发明申请公开(公告)号：US20180258455A1
公开(公告)日：2018-09-13
申请号：US15977254
申请日：2018-05-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song GONG , John SULLIVAN , Rongdian FU , Yan WANG , Evan H. BURSEY , Man CHENG
IPC: C12P19/34 , C12Q1/686 , C12Q1/6804 , C07K16/40 , C12N9/12
CPC classification number: C12P19/34 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/80 , C12N9/1252 , C12Q1/6804 , C12Q1/686 , C12Q2531/113 , C12Q2527/125 , C12Q2521/101
Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
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公开(公告)号：US20170218444A1
公开(公告)日：2017-08-03
申请号：US15427845
申请日：2017-02-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steven OKINO , Yan WANG
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6804 , C12Q1/6806 , C12Q1/6837 , C12Q2521/301 , C12Q2525/204 , C12Q2521/125 , C12Q2521/331
Abstract: Methods for analyzing chromosomal DNA, including chromatin, are provided.
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