公开(公告)号：US12275989B2

公开(公告)日：2025-04-15

申请号：US18386975

申请日：2023-11-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi Xue ,  Joshua Ritchey ,  Robert Meltzer

IPC: C12Q1/68 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6816

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US11759780B2

公开(公告)日：2023-09-19

申请号：US17153311

申请日：2021-01-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua Ritchey ,  Yi Xue ,  Robert Meltzer

IPC: B01L3/00 ,  C09D183/04 ,  C09D183/00 ,  B81C1/00 ,  C12Q1/686

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502784 ,  B81C1/00206 ,  C09D183/00 ,  C09D183/04 ,  B01L2200/06 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/04 ,  C12Q1/686 ,  C09D183/04 ,  C08K3/36

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

公开(公告)号：US11845980B2

公开(公告)日：2023-12-19

申请号：US17665170

申请日：2022-02-04

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi Xue ,  Joshua Ritchey ,  Robert Meltzer

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6844 ,  C12Q1/6816

CPC classification number: C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6846 ,  C12Q1/6816 ,  C12Q2527/125 ,  C12Q2563/159 ,  C12Q1/6846 ,  C12Q2527/137 ,  C12Q2563/159

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US11274337B2

公开(公告)日：2022-03-15

申请号：US16921453

申请日：2020-07-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi Xue ,  Joshua Ritchey ,  Robert Meltzer

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6844 ,  C12Q1/6816

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US11118217B2

公开(公告)日：2021-09-14

申请号：US15882098

申请日：2018-01-29

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi Xue ,  Joshua Ritchey ,  Robert Meltzer

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6844 ,  C12Q1/6816

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US10919038B2

公开(公告)日：2021-02-16

申请号：US15855913

申请日：2017-12-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua Ritchey ,  Yi Xue ,  Robert Meltzer

IPC: C09D183/04 ,  B01L3/00 ,  C09D183/00 ,  B81C1/00 ,  C12Q1/686

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.