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公开(公告)号：US06818754B1
公开(公告)日：2004-11-16
申请号：US10461791
申请日：2003-06-12
申请人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C12Q168
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/4703 , C07K14/70503 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。
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2.发明授权Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides 失效与α-2-巨球蛋白样多肽和多核苷酸有关的方法和材料公开(公告)号：US06806254B2
公开(公告)日：2004-10-19
申请号：US09756247
申请日：2001-01-08
申请人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
发明人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
IPC分类号： A61K3800
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/8107 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由这样的多核苷酸编码的新的多核苷酸和多肽，其对应于新型人分泌的α-2-巨球蛋白样多肽的突变体或其变体。 这些多核苷酸包含从胎儿脑mRNA（Clontech）（SEQ ID NO：1）和子宫mRNA（Clontech）（SEQ ID NO：26）的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有产生新的人分泌的α-2-巨球蛋白样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US06635742B1
公开(公告)日：2003-10-21
申请号：US09653274
申请日：2000-08-31
申请人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C07K1600
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/4703 , C07K14/70503 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。
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4.发明授权Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides 失效与新型凝血酶原酶样多肽和多核苷酸相关的方法和材料公开(公告)号：US06586390B1
公开(公告)日：2003-07-01
申请号：US09596196
申请日：2000-06-17
申请人： Dana A. Haley , Bryan J. Boyle , Alice S. Ho , Matthew C. Arterburn , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac , Nancy K. Mize
发明人： Dana A. Haley , Bryan J. Boyle , Alice S. Ho , Matthew C. Arterburn , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac , Nancy K. Mize
IPC分类号： A61K3800
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human ovary (Hyseq clone identification number 7735656). Other aspects of the invention include vectors containing processes for producing novel human prothrombinase-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由对应于新型人凝血酶原酶样多肽的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人卵巢cDNA文库中分离的核酸序列（Hyseq克隆鉴定号7735656）。 本发明的其它方面包括含有产生新的人类凝血酶原酶样多肽的方法的载体，以及对这些多肽具有特异性的抗体。
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5.发明授权Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides 失效与新型血管性血友病/血小板反应素样多肽和多核苷酸有关的方法和材料公开(公告)号：US06465620B1
公开(公告)日：2002-10-15
申请号：US09602543
申请日：2000-06-21
申请人： Bryan J. Boyle , Nancy K. Mize , Matthew C. Arterburn , Y. Tom Tang , John S. Tillinghast , Ankura Sinku , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , Nancy K. Mize , Matthew C. Arterburn , Y. Tom Tang , John S. Tillinghast , Ankura Sinku , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K14/78
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human von Willebrand/Thrombospondin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human fetal brain (Hyseq clone identification number 15258924). Other aspects of the invention include vectors containing processes for producing novel human von Willebrand/Thrombospondin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人血管性血友病素/血小板反应蛋白样多肽的突变体或其变体相对应。 这些多核苷酸包含从人胎脑的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号15258924）。 本发明的其它方面包括含有生产新的人血管性血友病/血小板凝集素样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US07317099B2
公开(公告)日：2008-01-08
申请号：US10168365
申请日：2000-12-23
申请人： Ivan Labat , Y. Tom Tang , Radoje T. Drmanac , Chenghua Liu , Juhi Lee , Nancy K. Mize , John Childs , Cheng-Chi Chao
发明人： Ivan Labat , Y. Tom Tang , Radoje T. Drmanac , Chenghua Liu , Juhi Lee , Nancy K. Mize , John Childs , Cheng-Chi Chao
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的干细胞生长因子样多肽的突变体或其变体。 这些多核苷酸包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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7.发明授权Methods and materials relating to CD84-like polypeptides and polynucleotides 失效与CD84样多肽和多核苷酸相关的方法和材料公开(公告)号：US07425610B2
公开(公告)日：2008-09-16
申请号：US10311829
申请日：2001-01-25
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polyeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸和突变体或其变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这种多肽特异性的抗体。
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8.发明申请Methods and Materials Relating to CD84-like Polypeptides and Polynucleotides 审中-公开与CD84样多肽和多核苷酸相关的方法和材料公开(公告)号：US20090042199A1
公开(公告)日：2009-02-12
申请号：US12100713
申请日：2008-04-10
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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9.发明申请Methods and Materials Relating to CD84-like Polypeptides and Polynucelotides 有权与CD84样多肽和多聚核糖核酸相关的方法和材料公开(公告)号：US20090023659A1
公开(公告)日：2009-01-22
申请号：US12195282
申请日：2008-08-20
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K38/17 , G01N33/53 , C12P21/02 , A61K31/7088 , C12Q1/68
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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10.发明申请METHODS AND MATERIALS RELATING TO CD84-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开与CD84-样多肽和多核苷酸相关的方法和材料公开(公告)号：US20110268724A1
公开(公告)日：2011-11-03
申请号：US13179183
申请日：2011-07-08
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395 , C12P21/02 , A61K31/7088 , A61P35/00 , A61P37/06 , A61P29/00 , A61P17/06 , A61P1/00 , G01N33/53 , A61P31/12
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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