公开(公告)号：US07317099B2

公开(公告)日：2008-01-08

申请号：US10168365

申请日：2000-12-23

申请人： Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

发明人： Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/10 ,  C12N1/15 ,  C12N15/21

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的干细胞生长因子样多肽的突变体或其变体。 这些多核苷酸包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US06667391B1

公开(公告)日：2003-12-23

申请号：US09764325

申请日：2001-01-16

申请人： Radoje T. Drmanac ,  Ivan Labat ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy K. Mize ,  John Childs

发明人： Radoje T. Drmanac ,  Ivan Labat ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy K. Mize ,  John Childs

IPC分类号： C07K200

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/47 ,  Y10S435/81 ,  Y10S435/975

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿肝脏脾脏（Hyseq克隆鉴定号6118092），卵巢（Hyseq克隆鉴定号8375786），成年脑（Hyseq克隆鉴定号701734,15327638,15741682,15954941,15955015）分离的核酸序列， 肺癌（Hyseq克隆鉴定号11047146和10280328），脊髓（Hyseq克隆鉴定号10102150），宫颈（Hyseq克隆鉴定号10022437和14029194），卵巢（Hyseq克隆鉴定号8319153），内皮细胞（Hyseq克隆鉴定号13815744 ），脐带（Hyseq克隆鉴定号18568149），淋巴细胞（Hyseq克隆鉴定号10257378），肺成纤维细胞（Hyseq克隆鉴定号17116257），胎儿脑（Hyseq克隆鉴定号码15266959）和睾丸。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US06673904B2

公开(公告)日：2004-01-06

申请号：US09912935

申请日：2001-07-24

申请人： Mitsuo Nishikawa ,  Ivan Labat ,  Radoje T. Drmanac ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy Mize ,  John Childs

发明人： Mitsuo Nishikawa ,  Ivan Labat ,  Radoje T. Drmanac ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy Mize ,  John Childs

IPC分类号： A61K3800

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K2039/53 ,  Y10S435/81 ,  Y10S435/975

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供由对应于新型人和小鼠分泌的干细胞生长因子样多肽的这种多核苷酸和突变体或其变体编码的新型多核苷酸和多肽。 这些多核苷酸包括从小鼠骨髓和人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，胎盘，淋巴细胞，肺成纤维细胞，胎儿中制备的cDNA文库中分离的核酸序列 大脑和睾丸。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20060074044A1

公开(公告)日：2006-04-06

申请号：US11283290

申请日：2005-11-18

申请人： Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

发明人： Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

CPC分类号： C07K14/475 ,  A61K38/00

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof the correspond to a novel human secreted stem cell growth factor-like polypeptide. These polypeptides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invertion include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其突变体或变体对应于新的人分泌的干细胞生长因子样多肽。 这些多肽包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 逆转的其他方面包括含有产生新的人分泌干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US08576286B1

公开(公告)日：2013-11-05

申请号：US13085233

申请日：2011-04-12

申请人： John Childs

发明人： John Childs

IPC分类号： H04N13/00

CPC分类号： H04N5/23203 ,  G01C21/00 ,  H04N5/247 ,  H04N7/181 ,  H04N13/243 ,  H04N13/246

摘要： A system and method for video navigation is disclosed. The system and method may include one or more video cameras configured to capture views external to the vehicle, a control mechanism for adjusting the sight-line of the one or more video cameras, and a display panel positioned within the vehicle for displaying the views captured within the sight-line of the one or more video cameras.

摘要翻译： 公开了一种用于视频导航的系统和方法。 该系统和方法可以包括被配置为捕获车辆外部视图的一个或多个摄像机，用于调整一个或多个摄像机的瞄准线的控制机构，以及定位在车辆内的显示面板，用于显示被捕获的视图 在一个或多个摄像机的视线内。

公开(公告)号：US08033222B1

公开(公告)日：2011-10-11

申请号：US11861751

申请日：2007-09-26

申请人： Daniel P. Sutula, Jr. ,  Mark T. Andersen ,  Basilio J. Carneiro ,  Lawrence J. Shank, III ,  John Childs

发明人： Daniel P. Sutula, Jr. ,  Mark T. Andersen ,  Basilio J. Carneiro ,  Lawrence J. Shank, III ,  John Childs

IPC分类号： C06C5/06

CPC分类号： C06C5/06

摘要： A connector clip (10, 10′) defines a line-retaining slot (34) and is configured to receive a detonator (16) therein. The connector clip (10, 10′) comprises a body member (12, 12′) and a closure member (14, 14′) which are mounted, one on the other, for movement relative to each other along a travel path between an open position in which the line-retaining slot (34) is accessible to lateral insertion therein of one or more signal transmission lines (68), and a closed position in which the line-retaining slot (34) is closed to secure such signal transmission lines (68) therein. One of the body member (12, 12′) and the closure member (14, 14′) defines a cavity within which at least part of the other of the body member (12, 12′) and the closure member (14, 14′) is encased during travel between the open position and the closed position. The travel path between the open position and the closed position may be as short as from the width of line-retaining slot (34) including its access opening (38), to about two times that width.

摘要翻译： 连接器夹（10,10'）限定线路保持槽（34），并且构造成在其中容纳雷管（16）。 连接器夹（10,10'）包括本体构件（12,12'）和闭合构件（14,14'），所述闭合构件（14,14'）彼此相对安装，以相对于彼此沿着 打开位置，其中线路保持槽（34）在其中横向插入其中的一个或多个信号传输线（68）可接近，并且闭合位置，其中线路保持槽（34）关闭以固定这种信号传输 线（68）。 主体构件（12,12'）和闭合构件（14,14'）中的一个限定了空腔，其中主体构件（12,12'）和封闭构件（14,14）中的另一个的至少一部分 '）在打开位置和关闭位置之间的行进期间被包围。 打开位置和关闭位置之间的行进路径可以从包括其进入开口（38）的线路保持槽（34）的宽度那样短到大约两倍的宽度。

公开(公告)号：US08794152B2

公开(公告)日：2014-08-05

申请号：US13582880

申请日：2011-03-09

申请人： Tyson J. Plitt ,  Joseph W. Twarog, Jr. ,  Mark Dorman ,  Raymond T. Overstrom ,  John Childs

发明人： Tyson J. Plitt ,  Joseph W. Twarog, Jr. ,  Mark Dorman ,  Raymond T. Overstrom ,  John Childs

IPC分类号： C06C5/06 ,  F42B3/195 ,  F42B3/107 ,  C06C7/00

CPC分类号： C06C7/00 ,  F42B3/107 ,  F42B3/195

摘要： A gas-impermeable sealer element (24, 124) for a detonator or other explosive initiation device includes a non-reactive sleeve (26, 126) having a channel (28, 128) formed therein. A reactive material strip (30, 130) is sealed within the channel for transmission of an explosive's initiation signal through the sealer element (24, 124), either alone or in cooperation with transfer charges located at the input and/or output end of the non-reactive sleeve (26, 126). The reactive material strip (30, 130) comprises a reactive metal wire or other substrate (34) having on one or both sides thereof a layer of reactive material (30, 130, 36), either reactive metal foils which react exothermically when ignited, or a deposited fuel-oxidizer reactive material. The reactive materials, upon being energized, react exothermically in the absence of atmospheric oxygen or other extraneous oxidizer and so may be encapsulated, sealed or otherwise isolated from the atmosphere in use.

摘要翻译： 用于雷管或其他爆炸引发装置的气体不可渗透的密封元件（24,124）包括具有形成在其中的通道（28,128）的非反应套筒（26,126）。 反应性材料条（30,130）被密封在通道内，用于通过密封元件（24,124）单独或与位于输送端和/或输出端的转印电荷协同传输爆炸物的起始信号 非反应套筒（26,126）。 反应性材料条（30,130）包括反应性金属线或其它基底（34），其在其一侧或两侧上具有一层反应性材料（30,130,36），当被点燃时反应性放热反应的金属箔， 或沉积的燃料 - 氧化剂反应性材料。 反应性材料在通电时，在没有大气氧或其他外来氧化剂的情况下放热反应，因此可以在使用中被封装，密封或与大气隔离。

公开(公告)号：US07650840B2

公开(公告)日：2010-01-26

申请号：US11348698

申请日：2006-02-06

申请人： John Childs ,  Lawrence J. Shank, III

发明人： John Childs ,  Lawrence J. Shank, III

IPC分类号： F42C9/00

CPC分类号： F42C9/10

摘要： A delay unit (10) comprises a timing strip (14) and, optionally, a calibration strip (20) deposited on a substrate (12). The timing and calibration strips comprise energetic materials which optionally may comprise particles of nanosize materials, e.g., a fuel and an oxidizer, optionally applied as separate layers. A method of making the delay units comprises depositing onto a substrate (12) a timing strip (14) having a starting point (14d) and a discharge point (14e) and depositing onto the same or another substrate a calibration strip (20). Timing strip (14) and calibration strip (20) are of identical composition and are otherwise configured, e.g., thickness of the strips, to have identical burn rates. The calibration strip (20) is ignited and its burn rate is ascertained. The timing strip (14) is adjusted by an adjustment structure to attain a desired delay period, preferably on the basis that the burn rate of the timing strip (14) is substantially identical to that of the calibration strip (20) and ascertaining the burn rate of the calibration strip. The adjustment may be attained by one or more of providing the timing strip with jump gaps (164), an accelerant or retardant (166a, 166b), completing the timing strip with a bridging strip (14c), or establishing a selected effective length of the timing strip by positioning one or both of a pick-up charge (16) and relay charge (18) over a portion of the timing strip.

摘要翻译： 延迟单元（10）包括定时条（14）和可选地沉积在基底（12）上的校准条（20）。 定时和校准条包括高能材料，其任选地可以包括纳米尺寸材料的颗粒，例如燃料和氧化剂，任选地作为单独的层应用。 制造延迟单元的方法包括将具有起始点（14d）和放电点（14e）的定时条（14）沉积到基板（12）上，并在相同或另一基板上沉积校准条（20）。 定时条（14）和校准条（20）具有相同的组成，并且以其它方式配置，例如条的厚度，具有相同的燃烧速率。 校准条（20）被点燃并确定燃烧速率。 优选地，基于正时条（14）的燃烧速率基本上与校准条（20）的燃烧速率基本相同并且确定烧伤（14）的调整结构来调整定时条（14）以获得期望的延迟周期 校准条的速率。 可以通过以下一个或多个来实现调整：将定时带提供有跳跃间隙（164），促进剂或阻燃剂（166a，166b），用桥接条（14c）完成定时带，或者建立选定的有效长度 定时条通过将拾取电荷（16）和中继电荷（18）中的一个或两个定位在定时条的一部分上。

公开(公告)号：USD468490S1

公开(公告)日：2003-01-07

申请号：US29132998

申请日：2000-11-20

申请人： John Childs

设计人： John Childs

公开(公告)号：US20130057512A1

公开(公告)日：2013-03-07

申请号：US13606547

申请日：2012-09-07

申请人： Jeffrey Lillie ,  John Childs ,  Christopher Ludden ,  Thomas Mackin ,  Petr Shepelev

发明人： Jeffrey Lillie ,  John Childs ,  Christopher Ludden ,  Thomas Mackin ,  Petr Shepelev

IPC分类号： G06F3/044

CPC分类号： G06F3/044 ,  G06F3/0412 ,  G06F3/0416 ,  G09G5/18

摘要： Embodiments of the invention generally provide an input device with display screens that periodically update (refresh) the screen by selectively driving common electrodes corresponding to pixels in a display line. In general, the input devices drive each electrode until each display line (and each pixel) of a display frame is updated. In addition to updating the display, the input device may perform capacitive sensing using the display screen as a proximity sensing area. To do this, the input device may interleave periods of capacitive sensing between periods of updating the display based on a display frame. For example, the input device may update the first half of display lines of the display screen, pause display updating, perform capacitive sensing, and finish updating the rest of the display lines. Further still, the input device may use common electrodes for both updating the display and performing capacitive sensing.