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公开(公告)号：US5382286A
公开(公告)日：1995-01-17
申请号：US91297
申请日：1993-07-15
IPC分类号： C08L5/08 , G01S7/524 , G10K11/00 , G10K11/02 , C09D105/08
CPC分类号： C08L5/08 , G10K11/006 , G10K11/02 , G01S7/524
摘要： A method for reducing cavitation around underwater acoustic projectors is described. The projector is cleaned with a surfactant and then encapsulated with an aqueous gel containing a polysaccharide polymer such as a chitosan derivative, a hydrophilic stabilizer and a biocide.
摘要翻译： 描述了一种减少水下声学投影仪周围气蚀的方法。 投影仪用表面活性剂清洗，然后用含有多糖聚合物如壳聚糖衍生物，亲水性稳定剂和杀生物剂的含水凝胶包封。
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公开(公告)号：US5412084A
公开(公告)日：1995-05-02
申请号：US9083
申请日：1993-01-26
CPC分类号： C08B37/003 , A61K8/736 , A61Q19/00 , A61Q17/04
摘要： New derivatives of carboxymethyl chitosan are disclosed, which are designated as N,O-Carboxymethylchitosonium carboxylates. The derivatives are ammonium salts made by acidifying a substantially neutral suspension of solid N,O-carboxymethyl chitosan in a diluent with an aqueous solution of the carboxylic acid. The carboxylic acid substitutes on the primary amine sites of the N,O-carboxymethyl chitosan.
摘要翻译： 公开了羧甲基壳聚糖的新衍生物，其被称为N，O-羧甲基壳氨酸羧酸盐。 衍生物是通过用羧酸水溶液在稀释剂中酸化固体N，O-羧甲基壳聚糖的基本上中性的悬浮液而制得的铵盐。 羧酸代替N，O-羧甲基壳聚糖的伯胺位点。
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3.发明授权Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins 失效粘合剂N，O-羧甲基壳聚糖涂层，其抑制底物依赖性细胞和蛋白质的附着公开(公告)号：US06645947B1
公开(公告)日：2003-11-11
申请号：US09315480
申请日：1999-05-20
申请人： Clive M. Elson , Timothy D. G. Lee
发明人： Clive M. Elson , Timothy D. G. Lee
IPC分类号： A61K3173
CPC分类号： A61K31/722 , A61L24/08 , A61L27/34 , A61L29/085 , A61L31/042 , A61L31/10 , C12N5/0068 , C12N2533/72 , C08L5/08
摘要： The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.
摘要翻译： 本发明涉及通过将含有有效量的粘附性N，O-羧甲基壳聚糖的组合物施用于底物，从而防止或大大降低细胞和蛋白质附着物来抑制细胞和蛋白质附着于底物的方法。
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公开(公告)号：US5888988A
公开(公告)日：1999-03-30
申请号：US852005
申请日：1997-05-06
申请人： Clive M. Elson
发明人： Clive M. Elson
IPC分类号： A61K38/00 , A61K31/715 , A61K31/722 , A61K31/74 , A61K45/06 , A61L26/00 , A61L31/04 , A61P17/02 , A61P43/00 , C08B37/08 , A61K31/73 , A61F2/00
CPC分类号： C08B37/003 , A61K31/722 , A61L26/0023 , A61L31/042
摘要： Covalent compositions of N,O-carboxymethyl chitosan (NOCC) are disclosed. NOCC can be intra- or intermolecularly linked, either through a direct bond or through a bridging moiety. Also disclosed are methods for preparing and using the covalent NOCC compositions. The NOCC compositions are useful in the administration of therapeutically active compounds and for wound management.
摘要翻译： 公开了N，O-羧甲基壳聚糖（NOCC）的共价组成。 NOCC可以通过直接键或通过桥连部分进行分子内或分子内的连接。 还公开了制备和使用共价NOCC组合物的方法。 NOCC组合物可用于治疗活性化合物的施用和伤口管理。
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公开(公告)号：US08039448B2
公开(公告)日：2011-10-18
申请号：US12313014
申请日：2008-11-14
IPC分类号： A61K31/715
CPC分类号： C08B37/003 , A61K31/722 , A61K38/164 , A61K38/212
摘要： The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders.
摘要翻译： 本发明涉及N-乙酰化的N，O-羧基烷基壳多糖和使用壳聚糖治疗诸如癌症，神经系统疾病，尿路疾病和生殖道障碍的疾病的方法。
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6.发明授权Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use 失效粘附的N，O-羧甲基壳聚糖用于湿性组织的药物递送装置及其使用方法公开(公告)号：US06809085B1
公开(公告)日：2004-10-26
申请号：US09610281
申请日：2000-07-06
申请人： Clive M. Elson , Agis Kydonieus
发明人： Clive M. Elson , Agis Kydonieus
IPC分类号： A61K3173
CPC分类号： A61K31/722 , A61L24/08 , A61L27/34 , A61L29/085 , A61L31/042 , A61L31/10 , C12N5/0068 , C12N2533/72 , C08L5/08
摘要： The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particularly useful in vaginal, buccal and ocular devices.
摘要翻译： 本发明涉及用于潮湿组织的药物递送装置，特别是浆液腔中的粘膜组织和组织，以及其使用方法。 含有NOCC的装置粘附于粘膜组织，允许局部药物递送。 这些装置在阴道，口腔和眼睛装置中特别有用。
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公开(公告)号：US5645844A
公开(公告)日：1997-07-08
申请号：US483996
申请日：1995-06-07
CPC分类号： A01N25/18
摘要： The present invention features a method and composition for attracting a target insect to a selected location. The invention is based on the discovery that negatively charged chitosan polymers, e.g., NOCC, have advantageous properties for use in a semiochemical delivery system for releasing a volatile semiochemical at a substantially sustained rate over an extended period of time to attract a target insect to a selected location. The present invention may be used for monitoring a target insect by capturing the insect. Alternatively, the present invention may be used for the management of a target insect by disrupting mating patterns of such insects.
摘要翻译： 本发明的特征在于用于将目标昆虫吸引到选定位置的方法和组合物。 本发明基于以下发现：负电荷的壳聚糖聚合物（例如NOCC）具有用于在化学输送系统中的有利性质，用于在延长的时间段内以基本上持续的速率释放挥发性化学信息，以将目标昆虫吸引到 选定位置 本发明可以用于通过捕获昆虫来监测目标昆虫。 或者，本发明可以用于通过破坏这种昆虫的交配模式来管理目标昆虫。
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公开(公告)号：US5679658A
公开(公告)日：1997-10-21
申请号：US436770
申请日：1995-05-08
申请人： Clive M. Elson
发明人： Clive M. Elson
IPC分类号： A61K38/00 , A61K31/715 , A61K31/722 , A61K31/74 , A61L26/00 , A61L31/04 , A61P43/00 , A61K31/73 , A61F2/00 , C08B37/08
CPC分类号： A61L26/0023 , A61K31/722 , A61L31/042
摘要： The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is particularly effective as a post-surgical lavage and when used in conjunction with a NOCC gel coating, wound healing rate is unchanged while the number and severity of adhesions in greatly reduced.
摘要翻译： 本发明涉及一种治疗患者以最小化手术后粘连的方法以及用于本发明方法中的试剂盒。 该方法基于N，O-羧甲基壳聚糖（NOCC）作为伤口愈合灌洗和涂层的有利性质的时机。 NOCC溶液作为手术后灌洗液特别有效，当与NOCC凝胶涂层结合使用时，伤口愈合速率不变，粘连的数量和严重程度大大降低。
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