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![CRYSTALLINE FORMS OF 7-CHLORO-2-(4-(3-METHOXYAZETIDIN-1-YL)CYCLOHEXYL)-2,4-DIMETHYL-N-((6-METHYL-4-(METHYLTHIO)-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)BENZO[D][1,3]DIOXOLE-5-CARBOXAMIDE](/abs-image/US/2022/08/11/US20220251073A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220251073A1
公开(公告)日：2022-08-11
申请号：US17628947
申请日：2020-07-23
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Alamelu Banda , Victor S. Gehling
IPC: C07D405/14
Abstract: The present disclosure relates to a crystalline Form 1 of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-di -methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d] [1,3]dioxole-5-carboxamide, which is useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline form and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20220017502A1
公开(公告)日：2022-01-20
申请号：US17311526
申请日：2019-12-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Anna Gardberg , Victor S. Gehling , Avinash Khanna , Julian R. Levell , Jonathan E. Wilson , Kennedy Taveras
IPC: C07D413/12 , C07D413/14 , A61P35/00
Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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公开(公告)号：US20170312252A1
公开(公告)日：2017-11-02
申请号：US15482584
申请日：2017-04-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Kwong Wah Lai , Jun Liang , Birong Zhang , Sharada Labadie , Daniel Ortwine , Peter Dragovich , James Kiefer , Victor S. Gehling , Jean-Christophe Harmange
IPC: A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04
CPC classification number: A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2017/03/23/US20170079984A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170079984A1
公开(公告)日：2017-03-23
申请号：US15277854
申请日：2016-09-27
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Michael Charles Hewitt , Victor S. Gehling , Rishi G. Vaswani
IPC: A61K31/55
CPC classification number: A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09469646B2
公开(公告)日：2016-10-18
申请号：US14839273
申请日：2015-08-28
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150376190A1
公开(公告)日：2015-12-31
申请号：US14766632
申请日：2014-02-11
Applicant: CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
Abstract translation: 具有用于调节组蛋白甲基修饰酶的结构式（II）的试剂，其组合物和用途，例如作为抗癌剂。
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公开(公告)号：US20140275092A1
公开(公告)日：2014-09-18
申请号：US14209449
申请日：2014-03-13
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Steven F. Bellon , Victor S. Gehling , Jean-Christophe Harmange
IPC: C07D487/04 , C07D498/04
CPC classification number: C07D487/04 , A61K31/337 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/14 , C07D498/04 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作一种或多种组蛋白脱甲基酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US11274095B2
公开(公告)日：2022-03-15
申请号：US16856454
申请日：2020-04-23
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Alexandre Côté , Victor S. Gehling , Avinash Khanna , Ludivine Moine , Jacob I. Stuckey
IPC: C07D405/14 , C07D405/12 , A61P35/00
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US11013718B2
公开(公告)日：2021-05-25
申请号：US16671559
申请日：2019-11-01
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: C07D205/12 , A61K31/397 , A61P31/22 , A61P31/18 , A61P35/02 , A61K31/438 , C07D221/20 , A61P35/00
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20200317651A1
公开(公告)日：2020-10-08
申请号：US16856454
申请日：2020-04-23
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Alexandre Côté , Victor S. Gehling , Avinash Khanna , Ludivine Moine , Jacob I. Stuckey
IPC: C07D405/14 , A61P35/00 , C07D405/12
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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