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公开(公告)号：US12019058B2
公开(公告)日：2024-06-25
申请号：US17938618
申请日：2022-10-06
Applicant: Cytiva Sweden AB
Inventor： Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
CPC classification number: G01N30/8658 , G01N2030/027
Abstract: The present invention relates to a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.
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公开(公告)号：US20220128523A1
公开(公告)日：2022-04-28
申请号：US17430915
申请日：2020-02-24
Applicant: Cytiva Sweden AB
Inventor： Lars Mattsson , Ioana Erlandsson , Therese Westman , Enrique Carredano , Jenny Dunker
Abstract: The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.
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公开(公告)号：US20210239662A1
公开(公告)日：2021-08-05
申请号：US16975324
申请日：2019-02-20
Applicant: Cytiva Sweden AB
Inventor： Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
IPC: G01N30/86
Abstract: The present invention relates to a liquid chromatography system (90) configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller (91) configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.
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公开(公告)号：US11493489B2
公开(公告)日：2022-11-08
申请号：US16975324
申请日：2019-02-20
Applicant: Cytiva Sweden AB
Inventor： Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
Abstract: The present invention relates to a liquid chromatography system (90) configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller (91) configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.
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Patent Agency Ranking
公开(公告)号：US20230028051A1
公开(公告)日：2023-01-26
申请号：US17938618
申请日：2022-10-06
Applicant: Cytiva Sweden AB
Inventor： Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
IPC: G01N30/86
Abstract: The present invention relates to a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.
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公开(公告)号：US20220163493A1
公开(公告)日：2022-05-26
申请号：US17602701
申请日：2020-04-16
Applicant: CYTIVA SWEDEN AB
Inventor： Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
IPC: G01N30/86
Abstract: Disclosed is a chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters such as h and As and optionally to further provide guidance to the user with respect to column efficiency, the system having a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in that column, thereby to calculate the efficiency of the column.
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公开(公告)号：US12188911B2
公开(公告)日：2025-01-07
申请号：US17602701
申请日：2020-04-16
Applicant: CYTIVA SWEDEN AB
Inventor： Jens Widehammar , Key Hyckenberg , Örjan Grelsson , Lars Mattsson , Kjell Karlsson
Abstract: A chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters and to further provide guidance to the user. The system has a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in the column, to calculate the efficiency of the column.
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公开(公告)号：US12158453B2
公开(公告)日：2024-12-03
申请号：US17430915
申请日：2020-02-24
Applicant: Cytiva Sweden AB
Inventor： Lars Mattsson , Ioana Erlandsson , Therese Westman , Enrique Carredano , Jenny Dunker
Abstract: The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.
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公开(公告)号：US20210269888A1
公开(公告)日：2021-09-02
申请号：US17253067
申请日：2019-07-01
Applicant: Cytiva Sweden AB
Inventor： Key Hyckenberg , Helena Skoglar , Gunnar Malmquist , Mikael Carlsten , Roger Lundqvist , Dan Andersson , Linda Mathiasson , Lars Mattsson , Sara Sendabo , Mikael Berg
Abstract: The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.
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