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1.发明申请GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS 有权来自CHO细胞的GLYCOPROTEIN产品中的GAL ALPHA含有1GG的含N-甘氨酸公开(公告)号：US20110045496A1
公开(公告)日：2011-02-24
申请号：US12529109
申请日：2009-01-22
申请人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
发明人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
CPC分类号： C12P21/005 , C07K14/70521 , C07K2319/30 , G01N33/5308 , G01N2400/02 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides methods of evaluating CHO cells.
摘要翻译： 本发明提供了评估CHO细胞的方法。
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2.发明授权Gal α1-3gal-containing N-glycans in glycoprotein products derived from CHO cells 有权来自CHO细胞的糖蛋白产物中含有α1α1-gal的N-聚糖公开(公告)号：US08586356B2
公开(公告)日：2013-11-19
申请号：US12529109
申请日：2009-01-22
申请人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
发明人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
CPC分类号： C12P21/005 , C07K14/70521 , C07K2319/30 , G01N33/5308 , G01N2400/02 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides methods of evaluating CHO cells.
摘要翻译： 本发明提供了评价CHO细胞的方法。
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3.发明申请公开(公告)号：US20060057638A1
公开(公告)日：2006-03-16
申请号：US11107982
申请日：2005-04-15
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
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4.发明授权公开(公告)号：US08000904B2
公开(公告)日：2011-08-16
申请号：US12574161
申请日：2009-10-06
申请人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
发明人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
IPC分类号： G01N31/00
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
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5.发明申请公开(公告)号：US20100144553A1
公开(公告)日：2010-06-10
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B40/12
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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6.发明申请公开(公告)号：US20120289415A1
公开(公告)日：2012-11-15
申请号：US13478662
申请日：2012-05-23
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B20/08
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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7.发明授权公开(公告)号：US08209132B2
公开(公告)日：2012-06-26
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： G01N31/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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公开(公告)号：US07553950B2
公开(公告)日：2009-06-30
申请号：US11638178
申请日：2006-12-13
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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公开(公告)号：US07507570B2
公开(公告)日：2009-03-24
申请号：US11078915
申请日：2005-03-10
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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公开(公告)号：US20100248260A1
公开(公告)日：2010-09-30
申请号：US12746033
申请日：2008-12-05
申请人： Zhihui BAN , Carlos Bosques , Ram Sasisekharan
发明人： Zhihui BAN , Carlos Bosques , Ram Sasisekharan
CPC分类号： A61K33/24 , B82Y5/00 , C12Q1/34 , C12Q1/527 , G01N2400/40 , Y10T428/2991
摘要： The present invention is directed to metallic particles coated with glycosaminoglycans and methods for preparing them. Methods of using such glycosaminoglycan-coated metallic particles in biomedical and other applications are also disclosed. In certain embodiments, methods for assaying glycosaminoglycan-degrading activity in biological fluids, test samples, and/or therapeutic formulations using the glycosaminoglycan-coated particles are provided. Such methods may be used, for example, in diagnostic tests for diseases such as cancer, inflammatory diseases, or autoimmune diseases and to test activity of enzymes being developed as therapeutics.
摘要翻译： 本发明涉及涂覆有糖胺聚糖的金属颗粒及其制备方法。 还公开了在生物医学和其它应用中使用这种糖胺聚糖包被的金属颗粒的方法。 在某些实施方案中，提供了使用糖胺聚糖包衣颗粒测定生物流体中的糖胺聚糖降解活性的方法，测试样品和/或治疗制剂。 这样的方法可以用于例如癌症，炎性疾病或自身免疫性疾病等疾病的诊断试验，并测试作为治疗剂开发的酶的活性。
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