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    Calibrated spectrographic imaging
    7.
    发明授权
    Calibrated spectrographic imaging 失效
    校准的光谱成像

    公开(公告)号：US5452723A

    公开(公告)日：1995-09-26

    申请号：US920135

    申请日：1992-07-24

    申请人： Jun Wu ,  Michael S. Feld ,  Richard P. Rava ,  Firooz Partovi

    发明人： Jun Wu ,  Michael S. Feld ,  Richard P. Rava ,  Firooz Partovi

    IPC分类号： A61B5/00 ,  G01N21/49 ,  G01N21/64 ,  A61B6/00

    CPC分类号： G01N21/6486 ,  A61B5/0059 ,  G01N21/49 ,  G01N21/65 ,  A61B2562/146

    摘要： The present application is directed to the use of photon migration analysis to provide a method of analyzing the diffuse reflectance, fluorescence, Raman or other types of spectra obtained from tissue. This procedure provides a means for processing spectral data such that the distortion in fluorescence spectra, for example, caused by the interplay of a variety of factors such as scattering, absorption, geometry and boundary conditions, can be precisely removed simply by measuring the diffuse reflectance spectrum as well as a second selected spectrum, such as fluorescence, and adjust the spectrum with the reflectance spectrum as described herein. By this procedure, the sample-to-sample variability is minimized. The intrinsic spectrum extracted by this procedure can be easily deconvoluted and provide quantitative information about the physicochemical composition of tissue. Analytical procedures for clinical diagnosis have been developed based on this method.

    摘要翻译： 本申请涉及使用光子迁移分析来提供从组织获得的漫反射，荧光，拉曼或其它类型的光谱的分析方法。 该过程提供了处理光谱数据的手段，使得例如由诸如散射，吸收，几何和边界条件等各种因素的相互作用引起的荧光光谱的失真可以通过简单地通过测量漫反射 光谱以及第二选定的光谱，例如荧光，并且如本文所述用反射光谱调节光谱。 通过这个过程，样品到样品的变异性最小化。 通过该方法提取的固有光谱可以容易地去卷积，并提供关于组织的物理化学组成的定量信息。 基于此方法开发了临床诊断分析手段。

    Analyzing copy number variation in the detection of cancer
    9.
    发明授权
    Analyzing copy number variation in the detection of cancer 有权

    公开(公告)号：US10388403B2

    公开(公告)日：2019-08-20

    申请号：US13555010

    申请日：2012-07-20

    申请人： Richard P. Rava ,  Brian K. Rhees

    发明人： Richard P. Rava ,  Brian K. Rhees

    IPC分类号： G06F19/22 ,  C12Q1/68 ,  G11C17/00 ,  G16B30/00 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6809 ,  G16H50/30 ,  G16H50/20 ,  C12Q1/6883 ,  C12Q1/6886

    摘要： The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.