公开(公告)号：US20210072269A1

公开(公告)日：2021-03-11

申请号：US16953870

申请日：2020-11-20

Applicant: Cepheid

Inventor： Ronald Chang ,  Steven Montgomery ,  Gregory Mote ,  Brian Bliven

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/04

Abstract: A handling system for high throughput processing of a large volume of biological samples is provided herein. Such systems can include an array support assembly that supports multiple diagnostic assay modules in an array having at least two dimensions, a loader that loads multiple diagnostic assay cartridges within the multiple diagnostic assay modules. The array support assembly can be movable relative the loader to facilitate loading and unloading so as to provide more efficient processing.

公开(公告)号：US20180143215A1

公开(公告)日：2018-05-24

申请号：US15816960

申请日：2017-11-17

Applicant: Cepheid

Inventor： Ronald Chang ,  Steven Montgomery ,  Gregory Mote ,  Brian Bliven

IPC: G01N35/02 ,  G01N35/04 ,  G01N35/00

Abstract: A handling system for high throughput processing of a large volume of biological samples is provided herein. Such systems can include an array support assembly that supports multiple diagnostic assay modules in an array having at least two dimensions, a loader that loads multiple diagnostic assay cartridges within the multiple diagnostic assay modules. The array support assembly can be movable relative the loader to facilitate loading and unloading so as to provide more efficient processing.

公开(公告)号：US08747782B2

公开(公告)日：2014-06-10

申请号：US13849640

申请日：2013-03-25

Applicant: Cepheid

Inventor： Ronald Chang ,  Douglas B. Dority ,  Steven Montgomery

IPC: B01L9/00 ,  B23Q7/04 ,  G07F11/16 ,  B65H5/00 ,  B65H1/08 ,  B65H3/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一个实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

公开(公告)号：US12235279B2

公开(公告)日：2025-02-25

申请号：US16953870

申请日：2020-11-20

Applicant: Cepheid

Inventor： Ronald Chang ,  Steven Montgomery ,  Gregory Mote ,  Brian Bliven

IPC: G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: A handling system for high throughput processing of a large volume of biological samples is provided herein. Such systems can include an array support assembly that supports multiple diagnostic assay modules in an array having at least two dimensions, a loader that loads multiple diagnostic assay cartridges within the multiple diagnostic assay modules. The array support assembly can be movable relative the loader to facilitate loading and unloading so as to provide more efficient processing.

公开(公告)号：US20140030817A1

公开(公告)日：2014-01-30

申请号：US13849640

申请日：2013-03-25

Applicant: Cepheid

Inventor： Ronald Chang ,  Douglas B. Dority ,  Steven Montgomery

IPC: B01L3/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一个实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

公开(公告)号：US09446409B2

公开(公告)日：2016-09-20

申请号：US14268682

申请日：2014-05-02

Applicant: Cepheid

Inventor： Ronald Chang ,  Douglas B. Dority ,  Steven Montgomery

IPC: B01L9/00 ,  B23Q7/04 ,  G07F11/16 ,  B65H5/00 ,  B65H1/08 ,  B65H3/00 ,  B01L3/00 ,  B01J19/00 ,  B01L3/02 ,  G01N35/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

公开(公告)号：US20140335627A1

公开(公告)日：2014-11-13

申请号：US14268682

申请日：2014-05-02

Applicant: Cepheid

Inventor： RONALD CHANG ,  Douglas B. Dority ,  Steven Montgomery

IPC: B01L3/00

CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。