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    Drug delivery compositions for improved stability of steroids
    2.
    发明授权
    Drug delivery compositions for improved stability of steroids 失效
    用于改善类固醇稳定性的药物输送组合物

    公开(公告)号：US5780050A

    公开(公告)日：1998-07-14

    申请号：US504430

    申请日：1995-07-20

    申请人： Uday Jain ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    发明人： Uday Jain ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC分类号： A61K9/70 ,  A61K31/565 ,  A61K31/57 ,  A61K47/04 ,  A61K47/10 ,  A61K47/14 ,  A61K47/16 ,  A61K47/20 ,  A61K47/30 ,  A61K47/32 ,  A61K47/44 ,  A61P5/24 ,  A61P5/38 ,  A61F13/00

    CPC分类号： A61K9/7061 ,  A61K31/568 ,  A61K31/569 ,  A61K31/57 ,  A61K31/573 ,  A61K31/575

    摘要： A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed.

    摘要翻译： 描述了一种用于经皮药物递送含有3-酮-4-烯官能团的类固醇药物的稳定补片装置，其中补片包含有效量的类固醇药物和不含酸官能团的载体。 该装置可以进一步含有添加剂如渗透促进剂或赋形剂，只要这些添加剂也不含酸官能团。 该装置可以是矩阵补丁或液体储存器补丁。 在基质贴剂中，载体是与类固醇药物紧密混合的生物相容的聚合物粘合剂。 粘合剂优选为丙烯酸类聚合物或共聚物。 在液体储存贴片中，载体是含有较薄或增稠剂的受控粘度组合物。 优选的类固醇药物包括某些皮质类固醇和性激素，如孕激素和雄激素。 还公开了在透皮贴剂储存期间稳定这种类固醇药物的方法。

    Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties
    3.
    发明授权
    Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties 有权
    含有聚二有机硅氧烷聚合物以调节粘合剂性能的透皮递送装置

    公开(公告)号：US06730318B2

    公开(公告)日：2004-05-04

    申请号：US09924564

    申请日：2001-08-08

    申请人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    发明人： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC分类号： A61F1302

    CPC分类号： A61K8/891 ,  A61F9/04 ,  A61F13/122 ,  A61F2013/00374 ,  A61F2013/00497 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K8/676 ,  A61K8/678 ,  A61K9/7053 ,  A61K9/7061 ,  A61Q19/00 ,  A61Q19/08

    摘要： The adhesive capability of matrix-type transdermal devices for the delivery of drugs, cosmetics, emollients and the like is altered by incorporating into the pressure-sensitive adhesive an effective amount of a polydiorganosiloxane polymer fluid adhesion adjusting agent. The properties of the pressure-sensitive adhesive are modified to enable a matrix-type patch to adhere temporarily to the skin for a period sufficient to accomplish its desired delivery purpose and then be removed without causing skin damage or irritation and without leaving substantial adhesive residue on the skin. Polydimethylsiloxanes (dimethicones) are preferred adhesion adjusting agents and acrylic-based polymers are preferred pressure-sensitive adhesives. Matrix-type patches containing anti-wrinkle agents formulated with dimethicones in the adhesive for application to areas on the face and particularly around the eyes are especially useful.

    摘要翻译： 用于递送药物，化妆品，润肤剂等的基质型透皮装置的粘合能力通过将有效量的聚二有机硅氧烷聚合物流体粘附调节剂并入压敏粘合剂而改变。 修改压敏粘合剂的性能以使基质型贴片能够临时粘附到皮肤上足够长的时间以实现其期望的递送目的，然后在不引起皮肤损伤或刺激的情况下被除去并且不会留下大量的粘合剂残留物 皮。 聚二甲基硅氧烷（二甲基硅氧烷）是优选的粘合调节剂，丙烯酸类聚合物是优选的压敏粘合剂。 在粘合剂中用二甲硅油配制的抗皱剂的基质型贴剂适用于脸部和特别是眼睛周围的区域是特别有用的。

    Transdermal delivery system with adhesive overlay and peel seal disc
    4.
    发明授权
    Transdermal delivery system with adhesive overlay and peel seal disc 失效
    透皮贴剂和剥离密封盘

    公开(公告)号：US5662925A

    公开(公告)日：1997-09-02

    申请号：US638440

    申请日：1996-04-26

    申请人： Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

    发明人： Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

    IPC分类号： A61K9/70 ,  A61L25/00

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay, a backing layer underlying the central portion of the adhesive overlay, an active agent-permeable membrane, the backing layer and membrane defining a reservoir that contains a formulation of the active agent, a peel seal disc underlying the active agent-permeable membrane, a heat seal about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.

    摘要翻译： 一种用于向个体的皮肤或粘膜施用活性剂的装置，其包括粘合剂覆盖物，粘合剂覆盖物的中心部分下方的背衬层，活性剂渗透膜，背衬层和膜的层压复合材料 储存器，其包含活性剂的制剂，活性剂渗透膜下面的剥离密封盘，围绕剥离密封盘的周边的热密封，活性剂可渗透膜和背衬层以及可移除的释放衬垫 暴露的覆盖层和剥离密封盘。 粘合剂层位于活性剂到皮肤或粘膜的路径之上和周边，并通过多种热封保护储存器的部件免于降解。 剥离密封盘防止含活性剂的储存器的释放，并且释放衬垫在使用之前保护粘合剂免于暴露于环境中。

    Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
    8.
    发明授权
    Subsaturated transdermal drug delivery device exhibiting enhanced drug flux 失效
    表现出增强的药物通量的亚饱和透皮药物递送装置

    公开(公告)号：US5164190A

    公开(公告)日：1992-11-17

    申请号：US626685

    申请日：1990-12-11

    申请人： Dinesh C. Patel ,  Charles D. Ebert

    发明人： Dinesh C. Patel ,  Charles D. Ebert

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7061

    摘要： Transdermal administration of hydrophobic drugs via a diffusion mechanism in which the drug is dissolved in a carrier at concentrations that are 20% to 80% of the saturation concentration. The flux of drug from the device is non-Fickian and is substantially greater than the flux observed when the drug is at saturation.

    摘要翻译： 通过扩散机制透析给药疏水性药物，其中药物以浓度为饱和浓度的20％至80％的浓度溶解在载体中。 来自该装置的药物流量是非Fickian，并且显着大于当药物饱和时观察到的通量。

    Device for administering an active agent to the skin or mucosa
    9.
    发明授权
    Device for administering an active agent to the skin or mucosa 失效
    用于向皮肤或粘膜施用活性剂的装置

    公开(公告)号：US4983395A

    公开(公告)日：1991-01-08

    申请号：US326536

    申请日：1989-03-21

    申请人： Yunik Chang ,  Dinesh C. Patel ,  Charles D. Ebert

    发明人： Yunik Chang ,  Dinesh C. Patel ,  Charles D. Ebert

    IPC分类号： A61F13/02 ,  A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： A transdermal drug delivery device comprising a drug formulation-containing reservoir defined by a backing layer and a drug-permeable membrane layer, a peelable inner liner that underlies the reservoir and a portion of the backing/membrane outwardly of the reservoir periphery, an adhesive layer that underlies the inner liner and outwardly extending portions of the membrane/backing layers, and a peelable release liner layer that underlies the adhesive layer with a first permanent heat seal between the backing and the membrane about the perimeter of the reservoir and another concentric peelable (impermanent) heat seal between the membrane and the inner liner positioned underlying and at a radius not less than the first permanent heat seal, the heat seals and peelable barrier layer providing barriers that isolate the drug formulation from the adhesive.

    摘要翻译： 一种透皮药物递送装置，其包括由背衬层和药物可渗透膜层限定的含药物制剂储存器，位于储存器下方的可剥离内衬层和位于储存器周边外部的背衬/膜的一部分，粘合剂层 位于膜/背衬层的内衬层和向外延伸部分之下的可剥离剥离衬垫层，以及位于粘合剂层下面的可剥离衬垫层，其中衬垫和膜周围围绕储存器的第一永久热密封，另一个同心可剥离（ 膜和内衬之间的热密封，其位于下方并且半径不小于第一永久热封，热密封和可剥离阻挡层提供将药物制剂与粘合剂隔离的障碍物。