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    Valve Frame
    3.
    发明申请
    Valve Frame 有权
    阀门框架

    公开(公告)号：US20090132037A1

    公开(公告)日：2009-05-21

    申请号：US12273168

    申请日：2008-11-18

    申请人： Grant T. Hoffman ,  Sean D. Chambers ,  Ram H. Paul, JR.

    发明人： Grant T. Hoffman ,  Sean D. Chambers ,  Ram H. Paul, JR.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2475 ,  A61F2/24 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058

    摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

    摘要翻译： 本公开涉及用于假体植入式阀的支撑框架。 支撑框架可以包括多个对称排列的互连的U形构件结构。 优选的支撑框架是包围纵向轴线并且包括面向支撑框架的远端或近端的多个U形构件结构的管状结构。 每个U形构件结构可以连接到面向相反纵向方向的单个纵向相邻的U形构件以及两个横向相邻的U形构件。

    Valve frame
    4.
    发明授权
    Valve frame 有权
    阀框

    公开(公告)号：US08313526B2

    公开(公告)日：2012-11-20

    申请号：US12273168

    申请日：2008-11-18

    申请人： Grant T. Hoffman ,  Sean D. Chambers ,  Ram H. Paul, Jr.

    发明人： Grant T. Hoffman ,  Sean D. Chambers ,  Ram H. Paul, Jr.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2475 ,  A61F2/24 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058

    摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

    摘要翻译： 本公开涉及用于假体植入式阀的支撑框架。 支撑框架可以包括多个对称排列的互连的U形构件结构。 优选的支撑框架是包围纵向轴线并且包括面向支撑框架的远端或近端的多个U形构件结构的管状结构。 每个U形构件结构可以连接到面向相反纵向方向的单个纵向相邻的U形构件以及两个横向相邻的U形构件。

    Adjustable Length Catheter
    5.
    发明申请
    Adjustable Length Catheter 有权
    可调长度导管

    公开(公告)号：US20080306465A1

    公开(公告)日：2008-12-11

    申请号：US11758543

    申请日：2007-06-05

    申请人： Frances Kristen Bailey ,  Jessica L. Burke ,  Grant T. Hoffman ,  Ram H. Paul, JR.

    发明人： Frances Kristen Bailey ,  Jessica L. Burke ,  Grant T. Hoffman ,  Ram H. Paul, JR.

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0097 ,  A61M25/0029 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0037

    摘要： An adjustable length catheter device, a kit and a method of providing the adjustable length catheter device to a patient are provided. The catheter device includes an elongate shaft having a proximal portion, a distal portion, a first lumen and a second lumen extending at least partially therethrough. The catheter device further includes a manifold operably connected to the shaft. The manifold is configured to longitudinally move along the shaft towards the distal portion for separating the proximal portion of the shaft into a first proximal shaft portion including the first lumen and a second proximal shaft portion including the second lumen.

    摘要翻译： 提供了一种可调节长度的导管装置，套件以及将可调节长度的导管装置提供给患者的方法。 导管装置包括细长轴，其具有近端部分，远端部分，第一内腔和至少部分延伸穿过其中的第二内腔。 导管装置还包括可操作地连接到轴的歧管。 歧管被构造成沿着轴朝向远端部分纵向移动，用于将轴的近端部分分离成包括第一管腔的第一近侧轴部分和包括第二管腔的第二近侧轴部分。

    Adjustable length catheter
    6.
    发明授权
    Adjustable length catheter 有权
    可调长导管

    公开(公告)号：US07798999B2

    公开(公告)日：2010-09-21

    申请号：US11758543

    申请日：2007-06-05

    申请人： Frances Kristen Bailey ,  Jessica L. Burke ,  Grant T. Hoffman ,  Ram H. Paul, Jr.

    发明人： Frances Kristen Bailey ,  Jessica L. Burke ,  Grant T. Hoffman ,  Ram H. Paul, Jr.

    IPC分类号： A61M5/178

    CPC分类号： A61M25/0097 ,  A61M25/0029 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0037

    摘要： An adjustable length catheter device, a kit and a method of providing the adjustable length catheter device to a patient are provided. The catheter device includes an elongate shaft having a proximal portion, a distal portion, a first lumen and a second lumen extending at least partially therethrough. The catheter device further includes a manifold operably connected to the shaft. The manifold is configured to longitudinally move along the shaft towards the distal portion for separating the proximal portion of the shaft into a first proximal shaft portion including the first lumen and a second proximal shaft portion including the second lumen.

    摘要翻译： 提供了一种可调节长度的导管装置，套件以及将可调节长度的导管装置提供给患者的方法。 导管装置包括细长轴，其具有近端部分，远端部分，第一内腔和至少部分延伸穿过其中的第二内腔。 导管装置还包括可操作地连接到轴的歧管。 歧管被构造成沿着轴朝向远端部分纵向移动，用于将轴的近端部分分离成包括第一管腔的第一近侧轴部分和包括第二管腔的第二近侧轴部分。

    Artificial prostheses with preferred geometries
    7.
    发明授权
    Artificial prostheses with preferred geometries 有权
    具有优选几何形状的人造假体

    公开(公告)号：US07717952B2

    公开(公告)日：2010-05-18

    申请号：US11586285

    申请日：2006-10-25

    申请人： Brian C. Case ,  Ram H. Paul, Jr. ,  Grant T. Hoffman

    发明人： Brian C. Case ,  Ram H. Paul, Jr. ,  Grant T. Hoffman

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0039

    摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.

    摘要翻译： 提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。 优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。 窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。 医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。 可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。 可植入的框架可以是自膨胀的或球囊的可膨胀的。 医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

    Delivery system for percutaneous placement of a medical device and method of use thereof
    8.
    发明授权
    Delivery system for percutaneous placement of a medical device and method of use thereof 有权
    用于经皮放置医疗装置的输送系统及其使用方法

    公开(公告)号：US08814847B2

    公开(公告)日：2014-08-26

    申请号：US11827848

    申请日：2007-07-13

    申请人： Grant T. Hoffman ,  F. Kristen Bailey

    发明人： Grant T. Hoffman ,  F. Kristen Bailey

    IPC分类号： A61M25/00 ,  A61F2/966 ,  A61F2/95

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61M25/0067 ,  A61M25/0068 ,  A61M25/007 ,  A61M2025/0006 ,  A61M2025/0079 ,  A61M2205/32

    摘要： A delivery system for implanting a medical device into the body of a patient or subject and a method of use thereof. The delivery system includes a delivery catheter having a catheter lumen and an inner member extending therethrough. The inner member includes a distal tip portion, a proximal portion, and an intermediate portion, the intermediate portion being disposed adjacent to the distal end of the delivery catheter. A first sealing member, positioned near a distal end of the proximal portion, forms a fluid seal between the inner member and an inside surface of the delivery catheter. A second sealing member, positioned near a proximal end of the distal tip portion, forms a fluid seal between the inner member and an inside surface of the delivery catheter. The intermediate portion extends between the first seal and the second seal. In one embodiment, a medical device and a hydrating fluid are present in a device-containing region between the intermediate portion and the delivery catheter.

    摘要翻译： 用于将医疗装置植入患者或受试者的身体的递送系统及其使用方法。 输送系统包括具有导管内腔和延伸穿过其中的内部构件的输送导管。 内部构件包括远侧末端部分，近侧部分和中间部分，中间部分邻近输送导管的远端设置。 位于近端部分的远端附近的第一密封构件在内部构件和输送导管的内表面之间形成流体密封。 定位在远侧末端部分的近端附近的第二密封构件在内部构件和输送导管的内表面之间形成流体密封。 中间部分在第一密封件和第二密封件之间延伸。 在一个实施例中，医疗装置和水合流体存在于中间部分和输送导管之间的装置容纳区域中。

    Method for anchoring occlusion plug
    9.
    发明授权
    Method for anchoring occlusion plug 有权
    锚栓塞方法

    公开(公告)号：US08518064B2

    公开(公告)日：2013-08-27

    申请号：US12641021

    申请日：2009-12-17

    申请人： Michael R. Kurrus ,  Grant T. Hoffman

    发明人： Michael R. Kurrus ,  Grant T. Hoffman

    IPC分类号： A61B17/08

    CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12159 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195

    摘要： A method for occluding a body vessel in a patient to block or reduce blood flow therethrough includes puncturing a blood vessel wall at a proximal vessel entry site with a hollow needle and extending the needle through the proximal entry site into the vessel lumen. The needle is extended through the vessel lumen and extended through the vessel wall at a distal vessel exit site into the extravascular space surrounding the distal vessel exit site. An expandable biocompatible material, such as expandable extracellular matrix (ECM) material, is then ejected though the distal end of the needle into the extravascular space. Then, while continuing to eject the expandable biocompatible plug material, the distal end of the needle is retracted back through the distal vessel exit site into the vessel lumen, such that the plug material continuously extends between the extravascular space surrounding the distal vessel exit site into the vessel lumen. When the plug material is delivered into the lumen of the vessel, the plug material expands, anchoring the plug material to the vessel wall, whereby the plug material forms an occluding plug in the vessel lumen blocking or reducing blood flow therethrough.

    摘要翻译： 一种用于阻塞患者体内容器以阻断或减少血液流过的方法，其中包括用中空针刺穿近端血管进入部位的血管壁并将针穿过近端进入部位延伸进入血管内腔。 针穿过血管内腔延伸穿过远端血管出口部位的血管壁进入远端血管出口部位周围的血管外空间。 然后将可膨胀的生物相容性材料，例如可扩张的细胞外基质（ECM）材料通过针的远端喷射到血管外空间中。 然后，在继续弹出可膨胀的生物相容性塞子材料的同时，针的远端通过远端血管出口部位回缩到血管内腔中，使得栓塞材料在围绕远端血管出口部位的血管外空间之间连续延伸到 血管腔。 当塞子材料被输送到容器的内腔中时，塞子材料膨胀，将塞子材料锚固到血管壁上，由此栓塞材料在血管腔中形成阻塞或减少通过其中的血液流动的阻塞塞。

    CLOSED SIDE-SAMPLING BIOPSY DEVICE
    10.
    发明申请
    CLOSED SIDE-SAMPLING BIOPSY DEVICE 有权
    封闭式采样生物设备

    公开(公告)号：US20120245487A1

    公开(公告)日：2012-09-27

    申请号：US13428038

    申请日：2012-03-23

    申请人： Robert Eells ,  Jeffry S. Melsheimer ,  Grant T. Hoffman

    发明人： Robert Eells ,  Jeffry S. Melsheimer ,  Grant T. Hoffman

    IPC分类号： A61B5/00

    CPC分类号： A61B10/0275 ,  A61B2010/0208

    摘要： Among other things, there are disclosed embodiments of a biopsy device using relative rotational motion to obtain a full-core biopsy sample. Inner and outer tubular members are provided connected to a handle. Each member includes a slit, and the members are rotatable with respect to each other. The device is inserted into a patient to a sampling site, and with the slits co-oriented, is extended into the sampling site. Tissue enters the tubular members through the slits, and one or both members are rotated to cut off and enclose tissue within the inner tubular member.

    摘要翻译： 除其他之外，公开了使用相对旋转运动以获得全核活检样本的活检装置的实施例。 提供连接到手柄的内部和外部管状构件。 每个构件包括狭缝，并且构件可相对于彼此旋转。 将该装置插入患者到采样部位，同时将狭缝合并，延伸到取样部位。 组织通过狭缝进入管状构件，并且旋转一个或两个构件以切断并将组织封闭在内部管状构件内。