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公开(公告)号：US07462822B2
公开(公告)日：2008-12-09
申请号：US11343922
申请日：2006-01-31
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： The invention relates to methods and devices for the transport of ions generated in gases near atmospheric pressure into the vacuum system of a mass spectrometer. Instead of the single capillary customary in commercial instruments, the invention uses a multichannel plate with hundreds of thousands of very short and narrow capillaries, whose total gas throughput is no higher than that of a normal single capillary. The large-area take-up of ions in the gas flow greatly increases the transfer yield. If the channels are conductive, this prevents the inside surfaces becoming charged. An ion funnel can separate the ions from the gas flow in the vacuum and focus them. Gas-dynamic focusing in an electric decelerating field reduces ion losses caused by wall collisions and prevents very light ions (protons, water clusters) from entering the vacuum. Staged multichannel plates reduce pumping requirements.
摘要翻译： 本发明涉及用于将在大气压附近的气体中产生的离子输送到质谱仪的真空系统中的方法和装置。 代替商业仪器中的单一毛细管常规，本发明使用具有数十万个非常短且窄的毛细管的多通道板，其总气体通量不高于正常单个毛细管。 气流中大面积吸收离子大大增加了转移产率。 如果通道是导电的，则防止内表面充电。 离子漏斗可以将离子与真空中的气流分离，并将其聚焦。 电动减速场中的气动聚焦减少了由壁碰撞引起的离子损失，并防止非常轻的离子（质子，水团）进入真空。 分段多通道板减少泵送要求。
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公开(公告)号：US20060186329A1
公开(公告)日：2006-08-24
申请号：US11343922
申请日：2006-01-31
IPC分类号： H01J49/00
CPC分类号： H01J49/0404
摘要： The invention relates to methods and devices for the transport of ions generated in gases near atmospheric pressure into the vacuum system of a mass spectrometer. Instead of the single capillary customary in commercial instruments, the invention uses a multichannel plate with hundreds of thousands of very short and narrow capillaries, whose total gas throughput is no higher than that of a normal single capillary. The large-area take-up of ions in the gas flow greatly increases the transfer yield. If the channels are conductive, this prevents the inside surfaces becoming charged. An ion funnel can separate the ions from the gas flow in the vacuum and focus them. Gas-dynamic focusing in an electric decelerating field reduces ion losses caused by wall collisions and prevents very light ions (protons, water clusters) from entering the vacuum. Staged multichannel plates reduce pumping requirements.
摘要翻译： 本发明涉及用于将在大气压附近的气体中产生的离子输送到质谱仪的真空系统中的方法和装置。 代替商业仪器中的单一毛细管常规，本发明使用具有数十万个非常短且窄的毛细管的多通道板，其总气体通量不高于正常单个毛细管。 气流中大面积吸收离子大大增加了转移产率。 如果通道是导电的，则防止内表面充电。 离子漏斗可以将离子与真空中的气流分离，并将其聚焦。 电动减速场中的气动聚焦减少了由壁碰撞引起的离子损失，并防止非常轻的离子（质子，水团）进入真空。 分段多通道板减少泵送要求。
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公开(公告)号：US07391021B2
公开(公告)日：2008-06-24
申请号：US11243440
申请日：2005-10-04
CPC分类号： H01J49/065 , H01J49/42
摘要： The invention relates to RF voltage-operated ion guides based on stacked apertured diaphragms. The invention provides ion guides consisting of diaphragm stacks that permit the ion beam to be shaped in cross-section so that it corresponds to the acceptance profile of the subsequent section of the device, therefore yielding optimal ion transmission. For this purpose, at least some of the diaphragms in the diaphragm stacks do not have circular openings, but instead have openings which shape the cross section of the emerging ion beam in the desired manner. It is possible, for instance, to obtain elliptical beam cross sections, divided beams or beams focused to the shape of a fine thread at the output of the diaphragm stacks.
摘要翻译： 本发明涉及基于堆叠多孔隔膜的射频电压操作离子导向器。 本发明提供了由隔膜叠层组成的离子导向器，其允许离子束的横截面成形，使得它对应于装置的后续部分的接受曲线，因此产生最佳的离子传播。 为此，膜片叠层中的至少一些隔膜不具有圆形开口，而是具有以期望的方式成形出现的离子束横截面的开口。 例如，可以获得椭圆形横截面，在光阑堆叠的输出处聚焦成细螺纹形状的分束或束。
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公开(公告)号：US06600154B1
公开(公告)日：2003-07-29
申请号：US09873107
申请日：2001-06-01
申请人： Jochen Franzen , Andreas Brekenfeld
发明人： Jochen Franzen , Andreas Brekenfeld
IPC分类号： H01J4942
CPC分类号： H01J49/4265
摘要： The invention relates to the control of the filling process of an ion trap with ions in order to avoid the deteriorating effect of too many stored ions on the quality of the spectrum during a mass scan. In the prior art, the “number of ions” inside the ion trap were used to contol filling. However, controlling the number of ions does not provide optimum trap filling for different ion compositions. The invention overcomes the problem by controlling a mass-dependent physical parameter and applying an cluster-dependent target value. This method takes into account the mass-dependency of optimum ion filling as well as the effect of non-uniform distribution of ions of different mass-to-charge ratios over the mass spectrum.
摘要翻译： 本发明涉及用离子控制离子阱的填充过程，以避免质量扫描期间太多储存离子对质谱的劣化作用。 在现有技术中，使用离子阱内部的“离子数”进行填充。 然而，控制离子数量不能为不同的离子组合物提供最佳的捕集阱填充。 本发明通过控制质量依赖物理参数并应用与簇相关的目标值来克服该问题。 该方法考虑了最佳离子填充的质量依赖性以及不同质荷比的离子在质谱上的不均匀分布的影响。
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公开(公告)号：US06410913B1
公开(公告)日：2002-06-25
申请号：US09613614
申请日：2000-07-11
IPC分类号： H01J4942
CPC分类号： H01J49/0063 , H01J49/424
摘要： The invention relates to the fragmentation of ions in ion traps filled with collision gas by exciting their axial oscillations in a dipole-shaped excitation field with a frequency mixture which covers the frequency of ion oscillations. The invention consists of ramping up the voltages of the frequency mixture for the dipolar excitation field, as a result of which, surprisingly, approximately the same fragmentation results are obtained for ions of different structures in the same fragmentation times as at a structurally specific optimal voltage applied at a constant level.
摘要翻译： 本发明涉及通过在具有覆盖离子振荡频率的频率混合物的偶极子形激发场中激发它们的轴向振荡来使填充有碰撞气体的离子阱中的离子的分裂。 本发明包括提高用于偶极激发场的频率混合的电压，结果令人惊奇的是，在与结构上特定的最佳电压相同的断裂时间中获得与不同结构的离子大致相同的断裂结果 应用在一个恒定的水平。
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公开(公告)号：US20060076485A1
公开(公告)日：2006-04-13
申请号：US11243440
申请日：2005-10-04
IPC分类号： B01D59/44
CPC分类号： H01J49/065 , H01J49/42
摘要： The invention relates to RF voltage-operated ion guides based on stacked apertured diaphragms. The invention provides ion guides consisting of diaphragm stacks that permit the ion beam to be shaped in cross-section so that it corresponds to the acceptance profile of the subsequent section of the device, therefore yielding optimal ion transmission. For this purpose, at least some of the diaphragms in the diaphragm stacks do not have circular openings, but instead have openings which shape the cross section of the emerging ion beam in the desired manner. It is possible, for instance, to obtain elliptical beam cross sections, divided beams or beams focused to the shape of a fine thread at the output of the diaphragm stacks.
摘要翻译： 本发明涉及基于堆叠多孔隔膜的射频电压操作离子导向器。 本发明提供了由隔膜叠层组成的离子导向器，其允许离子束的横截面成形，使得其对应于装置的后续部分的接受曲线，从而产生最佳的离子传播。 为此，膜片叠层中的至少一些隔膜不具有圆形开口，而是具有以期望的方式成形出现的离子束横截面的开口。 例如，可以获得椭圆形横截面，在光阑堆叠的输出处聚焦成细螺纹形状的分束或束。
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公开(公告)号：US06674071B2
公开(公告)日：2004-01-06
申请号：US10313924
申请日：2002-12-06
申请人： Jochen Franzen , Andreas Brekenfeld
发明人： Jochen Franzen , Andreas Brekenfeld
IPC分类号： H01J4942
CPC分类号： H01J49/062
摘要： The invention relates to ion-guide systems for the transfer, cooling, fragmentation, selection and temporary storage of ions. The invention consists in embedding systems, made from one or more straight or curved rods to which a single or multiphase radio frequency voltage is applied, in an external enveloping dc potential. The combination of the ion-repelling radio-frequency pseudo field around the rods and the external dc voltage field represents a new category of ion-guide systems. With external dc voltage fields, whose strength or penetration into the interior of the rod system varies along the axis of the system, the ions can be collected or propelled along the axis of the system. Filling the system with collision or damping gas allows the ions to be fragmented and cooled without any losses and the phase space volumes of the ions to be greatly reduced.
摘要翻译： 本发明涉及用于离子的转移，冷却，分解，选择和临时储存的离子导向系统。 本发明包括在外部包络直流电位中由一个或多个直线或弯曲棒制成单个或多相射频电压的嵌入系统。 棒周围的离子排斥射频伪场与外部直流电压场的组合代表了一类新的离子导向系统。 使用外部直流电压场，其强度或穿透到杆系内部的系统沿系统的轴线变化，离子可以沿着系统的轴线被收集或推进。 用碰撞或阻尼气体填充系统允许离子被破碎和冷却而没有任何损失，并且离子的相空间体积将大大降低。
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公开(公告)号：US11754572B2
公开(公告)日：2023-09-12
申请号：US13102212
申请日：2011-05-06
申请人： Markus Kostrzewa , Jochen Franzen
发明人： Markus Kostrzewa , Jochen Franzen
IPC分类号： C12Q1/04 , G01N33/68 , G01N33/569
CPC分类号： G01N33/6851 , G01N33/569
摘要： A method of detecting specified target microbes in different types of sample uses only one to two cultivation steps for the enrichment of the target microbes from the sample, preferably in selective culture media, combined with a mass spectrometric detection method that identifies the target microbes in mixtures with other microbes even if the target microbes account for only a small proportion of the mixture. The sample may be a food sample, a sample from bodies of water used for bathing, a soil sample, a swabbed sample, a stool sample, an impactor sample with collected aerosol particles, amongst many others. The detection method is several days faster than standard methods and less expensive.
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公开(公告)号：US08384019B2
公开(公告)日：2013-02-26
申请号：US12767273
申请日：2010-04-26
申请人： Claus Köster , Jochen Franzen
发明人： Claus Köster , Jochen Franzen
IPC分类号： B01D59/44
CPC分类号： H01J49/02 , H01J49/26 , H01J49/425
摘要： In a Kingdon ion trap in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction. The geometry of the Kingdon trap is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavy ions can be introduced into the trap.
摘要翻译： 在Kingdon离子阱中，纵向方向的势阱中的谐波离子振荡在垂直于纵向的方向上与离子振荡完全解耦，离子通过入口管进入陷阱，该入口管延伸通过一个 的Kingdon陷阱壳体电极并且位于纵向方向上的势阱的最小值之外。 Kingdon陷阱的几何形状被布置成使得通过入口管引入的振荡离子不能返回到入口管，直到它们执行几个纵向振荡，在该时间期间可以将重离子引入陷阱。
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公开(公告)号：US08319180B2
公开(公告)日：2012-11-27
申请号：US13208803
申请日：2011-08-12
申请人： Evgenij Nikolaev , Jochen Franzen
发明人： Evgenij Nikolaev , Jochen Franzen
CPC分类号： H01J49/4245
摘要： The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses.
摘要翻译： 本发明涉及静电傅立叶变换质谱仪的测量装置和用于以高质量分辨率采集质谱的测量方法。 测量装置包括根据Kingdon原理的静电测量单元，其中当适当的电压施加时，离子可以在围绕圆柱体轴线的圆周轨迹上轨道在两个同心圆柱表面之间，这两个同心圆柱表面由特殊形状的护套电极组成 另一个是抛物线间隙，并且可以在轴向方向上谐振振荡，而不受其轨道运动的影响。 在纵向方向上，测量单元的两个圆柱形表面被抛物线分离间隔分成不同类型的双角和四角形电极段。 护套电极段处的适当电压在两个同心圆柱形表面之间产生电位分布，这两个同心圆柱形表面在轴向方向上很好地形成抛物线势垒，用于轨道离子。 在该势阱中在轴向上谐波振荡的离子云在合适的电极中引起图像电流，通过傅立叶分析可以确定振荡频率。
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