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1.发明申请Burkholderia rhizoxina micro-organisms, novel endosymbionts of rhizopus sp. and method for producing rhizoxin and/or rhizoxin-derivates using said micro-organisms 审中-公开伯克霍尔德菌根瘤菌微生物，新根内根霉属的根霉属。 以及使用所述微生物生产根瘤菌素和/或根瘤菌素衍生物的方法公开(公告)号：US20090209013A1
公开(公告)日：2009-08-20
申请号：US11921698
申请日：2006-06-01
摘要： The invention relates to a method for producing rhizoxin and derivates of rhizoxin.The aim of the invention is to produce novel novel micro-organisms that synthesise rhizoxin or derivates of rhizoxin, and to provide a method for producing rhizoxin oder derivates thereof, without the disadvantages of prior art and in a simpler manner with a higher yield. To this end, bacterial symbionts of Rhizopus sp., in the form of Burkholderia Rhizoxina DSM 17360 or other Burkholderia Rhizoxina strains, are isolated, cultivated and used for the fermentive production of rhizoxin and/or derivates of rhizoxin in a submerged culture, and the rhizoxin and/or the derivates thereof are subsequently isolated from the culture supernatant.
摘要翻译： 本发明涉及根瘤菌素和根瘤菌素衍生物的制备方法。 本发明的目的是制备合成根瘤菌素或根瘤菌素衍生物的新型微生物，并提供一种生产根瘤菌素衍生物的方法，而不存在现有技术的缺点，并以更高的产率以更简单的方式。 为此，分离培养的根瘤菌（Burkholderia Rhizoxina DSM 17360）或其他伯克霍尔德杆菌（Rhkoxia Rhizoxina）菌株的根霉菌种的细菌共生体用于在浸没培养物中发酵生产根瘤菌素和/或根瘤菌素衍生物， 随后从培养上清中分离出根瘤菌素和/或其衍生物。
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2.发明授权Closthioamides, compositions, and methods for treating bacterial or fungal infections or cancer 有权Closthioamides，组合物和治疗细菌或真菌感染或癌症的方法公开(公告)号：US08673980B2
公开(公告)日：2014-03-18
申请号：US13504990
申请日：2010-11-02
申请人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
发明人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
IPC分类号： A01N37/18 , A61K31/16 , C07C327/00 , C07C321/00 , C07C323/00 , C07C325/00 , C07C335/00 , C07C381/00 , C07C255/00
CPC分类号： C07C327/48
摘要： This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
摘要翻译： 本发明涉及生物活性化合物领域，特别是涉及氯二甲酰胺，包含这些化合物的药物组合物及其作为抗生素，抗真菌剂和/或细胞毒性剂的用途。
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公开(公告)号：US20120270940A1
公开(公告)日：2012-10-25
申请号：US13504990
申请日：2010-11-02
申请人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
发明人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
IPC分类号： C07C327/48 , C07D475/04 , A61K31/166 , A61P35/00 , A61K31/277 , A61K31/197 , A61P31/04 , A61P31/10 , C07K16/00 , A61K31/222
CPC分类号： C07C327/48
摘要： This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
摘要翻译： 本发明涉及生物活性化合物领域，特别是涉及氯二甲酰胺，包含这些化合物的药物组合物及其作为抗生素，抗真菌剂和/或细胞毒性剂的用途。
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4.发明申请BENZOPYRANOBENZOTHIAZINONES AND THEIR USE AS FUNGICIDES, ANTIBIOTICS AND ANTITUMOR AGENTS 有权苯并噻唑啉酮及其作为杀真菌剂，抗生素和抗菌剂的用途公开(公告)号：US20140315896A1
公开(公告)日：2014-10-23
申请号：US14128095
申请日：2012-06-15
申请人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
发明人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
摘要翻译： 本发明涉及通式（I）的生物活性化合物领域，特别涉及赋形剂，其药理学上可接受的盐，溶剂合物，水合物或其药理学上可接受的制剂，包含这些化合物的药物组合物， phaeofungins及其作为杀真菌剂，抗生素以及抗肿瘤剂的用途。
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5.发明申请Antimitotic Rhizoxin Deritivatives of Burkholderia Rhizoxina, Method for Producing Said Derivatives and Use Thereof 审中-公开Burkholderia Rhizoxina的反刍根瘤菌素衍生物，生产所述衍生物的方法及其用途公开(公告)号：US20090233976A1
公开(公告)日：2009-09-17
申请号：US12083165
申请日：2006-09-25
IPC分类号： A61K31/422 , C07D493/04 , C12P17/18 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention concerns four novel secondary metabolites of the Burkholderia rhizoxina endosymbiont, a method for isolating said compounds from cultures of the bacteria and the use of said substances.The invention aims at providing novel rhizoxin derivatives with an antimitotic effect. Therefore, the following substances 1-4 are isolated, said substances exhibiting potential antifungal, cytotoxic and antiproliferative properties.
摘要翻译： 本发明涉及根瘤菌内毒素伯克霍尔德氏菌的四种新型次级代谢物，一种从细菌培养物中分离所述化合物的方法和所述物质的使用。 本发明旨在提供具有抗有丝分裂效应的新型根瘤菌素衍生物。 因此，以下物质1-4是分离的，所述物质具有潜在的抗真菌性，细胞毒性和抗增殖性。
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6.发明授权Benzopyranobenzothiazinones and their use as fungicides, antibiotics and antitumor agents 有权苯并吡唑并噻嗪酮及其作为杀真菌剂，抗生素和抗肿瘤剂的用途公开(公告)号：US09062077B2
公开(公告)日：2015-06-23
申请号：US14128095
申请日：2012-06-15
申请人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
发明人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
摘要翻译： 本发明涉及通式（I）的生物活性化合物领域，特别涉及发酵蛋白，或其药学上可接受的盐，溶剂合物，水合物或其药理学上可接受的制剂，包含这些化合物的药物组合物， phaeofungins及其作为杀真菌剂，抗生素以及抗肿瘤剂的用途。
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公开(公告)号：US20090142809A1
公开(公告)日：2009-06-04
申请号：US12084721
申请日：2006-09-25
申请人： Uwe Horn , Armin Siering , Gundela Peschel , Christian Hertweck , Peter-Jurgen Muller , Bettina Bardl , Jorg-Hermann Ozegowski , Kerstin Herold
发明人： Uwe Horn , Armin Siering , Gundela Peschel , Christian Hertweck , Peter-Jurgen Muller , Bettina Bardl , Jorg-Hermann Ozegowski , Kerstin Herold
IPC分类号： C12P19/56
CPC分类号： C12P19/56
摘要： The invention relates to a method for cleaving cervimycin esters. An object of the invention to convert in a simple manner the cervimycin esters which are less active but formed in larger quantity into the highly active cervimycin K that occurs as a minor component in the preparation by fermentation, is achieved by preparing unesterified cervimycins from cervimycin esters with di- or monomethylated malonic acids, by ester cleavage effected by at least one esterolytic enzyme at temperatures of 20° C. to 75° C. and a pH of pH 5.0 to 10.0, preferably pH 6.0 to 9.0.
摘要翻译： 本发明涉及一种切割子宫颈霉素酯的方法。 本发明的一个目的是以简单的方式将活性较低但以大量形成的子宫颈素酯转化成通过发酵作为制剂中作为次要成分发生的高活性的宫颈霉素K，通过从宫颈霉素酯制备未酯化的cervimycins来实现 通过在20℃至75℃的温度下由至少一种酯水解酶进行的酯切割，pH为5.0至10.0，优选pH 6.0至9.0的pH进行酯化裂解，得到二 - 或单甲基丙二酸。
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