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69 条记录 (耗时 0.04 秒)

    Compounds that Prevent Macrophage Apoptosis and Uses Thereof
    1.
    发明申请
    Compounds that Prevent Macrophage Apoptosis and Uses Thereof 审中-公开
    防止巨噬细胞凋亡及其用途的化合物

    公开(公告)号：US20090111786A1

    公开(公告)日：2009-04-30

    申请号：US11792154

    申请日：2005-12-02

    申请人： Christopher K. Glass ,  Annabel E. Valledor ,  Michael Karin ,  Li-Chung Hsu

    发明人： Christopher K. Glass ,  Annabel E. Valledor ,  Michael Karin ,  Li-Chung Hsu

    IPC分类号： A61K31/58 ,  C12N5/00 ,  A61K31/19 ,  A61P31/04

    CPC分类号： A61K38/1703 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

    摘要： The present invention relates to microbial infection, and in particular, the reduction of apoptosis associated with microbial infection, the screening of Liver X Receptor agonist and/or Retinoid X Receptor agonist that reduce apoptosis, and the treatment and analysis of microbial infection in vivo. In one embodiment, the present invention relates to Liver X Receptor agonist and/or Retinoid X Receptor agonist including but not limited to an agonist increasing the activity of Liver X Receptor and/or Retinoid X Receptor.

    摘要翻译： 本发明涉及微生物感染，特别涉及减少与微生物感染有关的细胞凋亡，筛选减少细胞凋亡的肝X受体激动剂和/或类视黄醇X受体激动剂，以及体内微生物感染的治疗和分析。 在一个实施方案中，本发明涉及肝X受体激动剂和/或类视黄醇X受体激动剂，其包括但不限于增加肝X受体和/或类视黄醇X受体活性的激动剂。

    Methods and compositions for reducing microbial induced apoptosis
    2.
    发明授权
    Methods and compositions for reducing microbial induced apoptosis 有权
    减少微生物诱导凋亡的方法和组合物

    公开(公告)号：US07776527B2

    公开(公告)日：2010-08-17

    申请号：US10578976

    申请日：2004-11-12

    申请人： Li-Chung Hsu ,  Michael Karin

    发明人： Li-Chung Hsu ,  Michael Karin

    IPC分类号： C12Q1/18 ,  C12Q1/48 ,  C12Q1/68

    CPC分类号： G01N33/5055 ,  C12Q1/485

    摘要： The present invention relates to microbial infection, and in particular, the reduction of apoptosis associated with microbial infection, the screening of agents that reduce apoptosis, and the treatment and analysis of microbial infection in vivo. In one embodiment, the present invention relates to agents including but not limited to reducing the activity of Protein Kinase R.

    摘要翻译： 本发明涉及微生物感染，特别是与微生物感染相关的细胞凋亡减少，减少细胞凋亡的药物的筛选以及体内微生物感染的治疗和分析。 在一个实施方案中，本发明涉及包括但不限于降低蛋白激酶R的活性的试剂。

    Methods and Compositions for Reducing Microbial Induced Apoptosis
    3.
    发明申请
    Methods and Compositions for Reducing Microbial Induced Apoptosis 有权
    减少微生物诱导凋亡的方法和组合

    公开(公告)号：US20070281328A1

    公开(公告)日：2007-12-06

    申请号：US10578976

    申请日：2004-11-12

    申请人： Li-Chung Hsu ,  Michael Karin

    发明人： Li-Chung Hsu ,  Michael Karin

    IPC分类号： C12Q1/18 ,  C12Q1/48

    CPC分类号： G01N33/5055 ,  C12Q1/485

    摘要： The present invention relates to microbial infection, and in particular, the reduction of apoptosis associated with microbial infection, the screening of agents that reduce apoptosis, and the treatment and analysis of microbial infection in vivo. In one embodiment, the present invention relates to agents including but not limited to reducing the activity of Protein Kinase R.

    摘要翻译： 本发明涉及微生物感染，特别是与微生物感染相关的细胞凋亡减少，减少细胞凋亡的药物的筛选以及体内微生物感染的治疗和分析。 在一个实施方案中，本发明涉及包括但不限于降低蛋白激酶R的活性的试剂。

    Compositions and methods for modulating NH2-terminal Jun Kinase activity
    7.
    发明授权
    Compositions and methods for modulating NH2-terminal Jun Kinase activity 失效
    调节NH2末端Jun激酶活性的组成和方法

    公开(公告)号：US07232897B2

    公开(公告)日：2007-06-19

    申请号：US10475505

    申请日：2002-04-24

    申请人： Gokhan S. Hotamisligil ,  Michael Karin ,  Lufen Chang

    发明人： Gokhan S. Hotamisligil ,  Michael Karin ,  Lufen Chang

    IPC分类号： C07H17/08 ,  A61K31/00

    CPC分类号： A61K31/675

    摘要： Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH2-terminal Jun Kinase activity can lead to the reduction in weight and improve insulin sensitivity.

    摘要翻译： 本文公开了用于调节NH 2 - 末端Jun激酶活性的组合物和方法。 这些组合物和方法可用于调节与诸如糖尿病之类的胰岛素相关的代谢紊乱。 NH 2 - 末端Jun激酶活性的降低可导致重量减轻并提高胰岛素敏感性。

    Methods for identifying and using IKK inhibitors
    8.
    发明授权
    Methods for identifying and using IKK inhibitors 有权

    公开(公告)号：US07053119B2

    公开(公告)日：2006-05-30

    申请号：US10376470

    申请日：2003-02-28

    申请人： Michael Karin ,  Pankaj Kapahi

    发明人： Michael Karin ,  Pankaj Kapahi

    IPC分类号： A61K31/215 ,  A61K31/12 ,  A61K31/035

    CPC分类号： A61K31/557 ,  A61K31/00 ,  A61K31/5575 ,  C12Q1/485 ,  G01N2500/04

    摘要： The present invention provides methods and compositions for inhibiting IKK, as well as methods and compositions for identifying compounds with activity as inhibitors of IKK, and methods and compositions for the treatment of diseases and/or conditions wherein IKK is implicated and inhibition of its activity is desired. In addition, the present invention provides methods and compositions for the improving the therapeutic activity of COX2 inhibitors, comprising administering the COX2 to a subject in combination with a compound that inhibits IKK activity. The present invention further provides compositions that comprise compounds that inhibit IKK and COX2.

    Mutations in IKK&ggr;
    9.
    发明授权
    Mutations in IKK&ggr; 失效
    IKKgamma中的突变

    公开(公告)号：US06689564B2

    公开(公告)日：2004-02-10

    申请号：US09882507

    申请日：2001-06-15

    申请人： Konstantinos Makris ,  Michael Karin

    发明人： Konstantinos Makris ,  Michael Karin

    IPC分类号： C12Q168

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0368 ,  C12N9/12 ,  C12N15/8509

    摘要： The present invention relates to compositions and methods involving IKK&ggr; mutants. In particular, the present invention provides methods and compositions, including transgenic animals, suitable for use in determining means to treat, control, and/or prevent incontinentia pigmenti (IP). The present invention also provides methods to detect the presence of mutations in the IKK&ggr; gene and protein.

    摘要翻译： 本发明涉及涉及IKKgamma突变体的组合物和方法。 特别地，本发明提供了包括转基因动物的方法和组合物，其适合用于确定治疗，控制和/或预防失色素（IP）的手段。 本发明还提供了检测IKKgamma基因和蛋白质中突变的存在的方法。

    Methods for identifying and using IKK inhibitors
    10.
    发明授权
    Methods for identifying and using IKK inhibitors 失效

    公开(公告)号：US06649654B1

    公开(公告)日：2003-11-18

    申请号：US09721380

    申请日：2000-11-22

    申请人： Michael Karin ,  Pankaj Kapahi

    发明人： Michael Karin ,  Pankaj Kapahi

    IPC分类号： A01N3708

    CPC分类号： A61K31/557 ,  A61K31/00 ,  A61K31/5575 ,  C12Q1/485 ,  G01N2500/04

    摘要： The present invention provides methods and compositions for inhibiting IKK, as well as methods and compositions for identifying compounds with activity as inhibitors of IKK, and methods and compositions for the treatment of diseases and/or conditions wherein IKK is implicated and inhibition of its activity is desired. In addition, the present invention provides methods and compositions for the improving the therapeutic activity of COX2 inhibitors, comprising administering the COX2 to a subject in combination with a compound that inhibits IKK activity. The present invention further provides compositions that comprise compounds that inhibit IKK and COX2.