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公开(公告)号：US07983467B2
公开(公告)日：2011-07-19
申请号：US12704350
申请日：2010-02-11
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
IPC: G06K9/00
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
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公开(公告)号：US08208710B2
公开(公告)日：2012-06-26
申请号：US13156928
申请日：2011-06-09
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
IPC: G06K9/00
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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公开(公告)号：US20120235016A1
公开(公告)日：2012-09-20
申请号：US13480888
申请日：2012-05-25
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleinik-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleinik-Ovod
IPC: H01L27/146
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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4.发明申请公开(公告)号：US20070239380A1
公开(公告)日：2007-10-11
申请号：US11231266
申请日：2005-09-20
Applicant: Christopher Miles
Inventor： Christopher Miles
IPC: G06F19/00
CPC classification number: G01N21/274 , G01N21/6428 , G01N21/6452
Abstract: In one embodiment, a method of determining a drift value is described that comprises performing one or more X-axis translations of an excitation beam over a probe array; measuring light responsive to the excitation beam from at least two positional reference elements associated with the probe array for the X-axis translations; calculating a distance value for the X-axis translation using a positional relationship of a known location associated with each of the positional reference elements and positions of the positional reference elements from the measured light; and determining a drift value using a difference between the calculated distance value and an expected distance value.
Abstract translation: 在一个实施例中，描述了确定漂移值的方法，其包括在探针阵列上执行激发束的一个或多个X轴平移; 测量响应于来自与用于X轴平移的探针阵列相关联的至少两个位置参考元件的激发光束的光; 使用与所述位置参考元素中的每一个相关联的已知位置和所述位置参考元素与所测量的光的位置的位置关系来计算所述X轴平移的距离值; 以及使用所计算的距离值和预期距离值之间的差来确定漂移值。
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公开(公告)号：US20050057676A1
公开(公告)日：2005-03-17
申请号：US10975788
申请日：2004-10-27
Applicant: Nathan Weiner , Patrick Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David Stura , Albert Bukys , Tim Woolaver , Thomas Regan , David Bradbury , Eric McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
Inventor： Nathan Weiner , Patrick Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David Stura , Albert Bukys , Tim Woolaver , Thomas Regan , David Bradbury , Eric McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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Patent Agency Ranking
公开(公告)号：US08391582B2
公开(公告)日：2013-03-05
申请号：US13480888
申请日：2012-05-25
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
IPC: G06K9/00
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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公开(公告)号：US07871812B2
公开(公告)日：2011-01-18
申请号：US10975788
申请日：2004-10-27
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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8.发明申请System and method for scanner instrument calibration using a calibration standard 审中-公开使用校准标准进行扫描仪仪器校准的系统和方法公开(公告)号：US20050030601A1
公开(公告)日：2005-02-10
申请号：US10868590
申请日：2004-06-14
Applicant: David Smith , Gregory Loney , Nathan Weiner , Christopher Miles , Albert Bukys , Akim Lennhoff , Robert Kuimelis
Inventor： David Smith , Gregory Loney , Nathan Weiner , Christopher Miles , Albert Bukys , Akim Lennhoff , Robert Kuimelis
CPC classification number: G01N21/6452 , G01N21/278
Abstract: In one embodiment a method for reducing variation in a plurality of scanners is described. The method comprises directing an excitation beam at a calibration standard in each of the plurality of scanners, where one of the plurality of scanners is a designated scanner; detecting emission data for each of the plurality of scanners from a plurality of fluorescent molecules disposed on the calibration standard, where the emission data is responsive to the excitation beam; determining variation in the emission data of one or more of the plurality of scanners based, at least in part, upon the emission data of the designated scanner; and adjusting one or more parameters in one or more of the plurality of scanners based, at least in part, upon the determined variation.
Abstract translation: 在一个实施例中，描述了用于减少多个扫描器中的变化的方法。 该方法包括以多个扫描仪中的每一个的校准标准来引导激励光束，其中多个扫描仪中的一个是指定的扫描器; 从布置在校准标准上的多个荧光分子检测多个扫描器中的每一个的发射数据，其中发射数据响应于激发光束; 至少部分地基于所指定的扫描仪的发射数据来确定所述多个扫描仪中的一个或多个的发射数据的变化; 以及至少部分地基于所确定的变化来调整所述多个扫描器中的一个或多个中的一个或多个参数。
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公开(公告)号：US20110243411A1
公开(公告)日：2011-10-06
申请号：US13156928
申请日：2011-06-09
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman DeWeerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman DeWeerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
IPC: G06K9/00
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
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公开(公告)号：US20100142850A1
公开(公告)日：2010-06-10
申请号：US12704350
申请日：2010-02-11
Applicant: Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
Inventor： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
IPC: G06K9/40
CPC classification number: G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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