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公开(公告)号：US08391582B2
公开(公告)日：2013-03-05
申请号：US13480888
申请日：2012-05-25
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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公开(公告)号：US08208710B2
公开(公告)日：2012-06-26
申请号：US13156928
申请日：2011-06-09
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。
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3.发明授权公开(公告)号：US07062092B2
公开(公告)日：2006-06-13
申请号：US09682071
申请日：2001-07-17
IPC分类号： G06K9/74
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , C40B50/14 , G01N27/44717 , G01N27/44721 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471 , G01N2035/00158 , G01N2035/0494 , G06F19/20 , G06F19/26
摘要： Systems, methods, and computer program products are described for adjusting the gain of a scanner. The scanner includes one or more excitation sources, an emission detector having a first gain, and a variable gain element having a second gain. One described method includes receiving a user-selected gain value, adjusting the first gain based on a first portion of the user-selected gain value, and adjusting the second gain based on a second portion of the user-selected gain value. Another described method includes selecting an auto-gain value, adjusting the first gain based on a first portion of the auto-gain value, adjusting the second gain based on a second portion of the auto-gain value, causing the scanner to collect sample pixel intensity values, determining a comparison measure based on comparing the sample pixel intensity values to desired pixel intensity values, and adjusting the auto-gain value based on the comparison measure.
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公开(公告)号：US07314595B2
公开(公告)日：2008-01-01
申请号：US10476603
申请日：2002-05-02
IPC分类号： B01L3/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , B01L3/0244 , B01L9/52 , B01L9/523 , B01L2200/025 , B01L2300/0822 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/028 , G01N2035/00158 , G01N2035/00237 , G01N2035/042 , G01N2035/0425 , Y10T436/11
摘要： A system is described for automatic retrieval of microplates from a carousel. The system includes an effector arm that retrieves a selected microplate from the carousel, a microplate retainer that receives the selected microplate from the effector arm, and a controller that directs the effector arm to the carousel for retrieval of the selected microplate and directs the effector arm to the microplate retainer so that it may receive the selected microplate. The carousel may revolve around a vertical axis. A system also is described for washing depositing elements used to spot biological materials on a substrate. Graphical user interfaces also are described for enabling a user to determine which microplates will be used to provide biological probe materials, and in what patterns those probe materials should be deposited on the substrate. The interfaces enable the user to place multiple fractions of biological materials on a same location on a substrate. Also described are graphical user interfaces that present a user with the options to select a first microplate having a plurality of wells, associate at least one probe material with one or more of the wells, and associate one or more locations on one or more substrates with the one or more wells.
摘要翻译： 描述了用于从旋转木马自动检索微孔板的系统。 所述系统包括效应器臂，所述效应器臂从所述圆盘传送带检索选定的微量培养板，从所述效应器臂接收所选微孔板的微孔板保持器，以及将所述效应器臂引导到所述圆盘传送带以取回所选微孔板并引导所述效应臂 到微板保持器，使得其可以接收所选择的微孔板。 圆盘传送带可绕垂直轴旋转。 还描述了用于洗涤沉积用于将基材上的生物材料定位的元件的系统。 还描述了图形用户界面，用于使用户能够确定哪些微孔板将用于提供生物探针材料，以及哪些图案将这些探针材料沉积在基底上。 界面使用户能够将多种生物材料的部分放置在基板上的相同位置上。 还描述了图形用户界面，其向用户呈现选择具有多个孔的第一微孔板的选项，将至少一个探针材料与一个或多个孔相关联，并将一个或多个底物上的一个或多个位置与 一个或多个井。
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