公开(公告)号：US20070224684A1

公开(公告)日：2007-09-27

申请号：US11387186

申请日：2006-03-22

Applicant: David Olson ,  Nathaniel Bair ,  Richard Fisher ,  Steve Martin ,  Collin Rich

Inventor： David Olson ,  Nathaniel Bair ,  Richard Fisher ,  Steve Martin ,  Collin Rich

IPC: G01N33/48

CPC classification number: G01N15/1459

Abstract: A first preferred embodiment includes a flow cytometer with a fluidic system to draw a sample fluid into an interrogation zone, a light source to emit light toward the sample fluid in the interrogation zone, an optic system to collect and detect at least one of a scattered light and a fluorescent light from the interrogation zone, and a processor. The flow cytometer, if properly boxed and labeled, complies with the parcel post requirements of the United States Postal Service. A second preferred embodiment includes the method of supplying a flow cytometer by shipping the flow cytometer via the United States Postal Service. A third preferred embodiment includes the method of servicing a flow cytometer by receiving the flow cytometer from a user via the United States Postal Service and servicing the flow cytometer.

Abstract translation: 第一优选实施方案包括流式细胞仪，其具有将样品流体吸入询问区的流体系统，向询问区中的样品流体发光的光源，用于收集和检测散射的至少一种的光学系统 来自询问区的光和荧光灯以及处理器。 流式细胞仪如果正确装箱和贴标签符合美国邮政局的包裹邮寄要求。 第二个优选实施方案包括通过美国邮政局运送流式细胞仪提供流式细胞仪的方法。 第三优选实施方案包括通过经由美国邮政局从用户接收流式细胞仪并服务于流式细胞仪来服务流式细胞仪的方法。

公开(公告)号：US20070127863A1

公开(公告)日：2007-06-07

申请号：US11297170

申请日：2005-12-07

Applicant: Nathaniel Bair ,  Richard Fisher ,  Collin Rich

Inventor： Nathaniel Bair ,  Richard Fisher ,  Collin Rich

IPC: G02B6/00

CPC classification number: G02B6/04 ,  G02B6/29361 ,  G02B6/4215

Abstract: An optical system for guiding light from an interrogation zone to a detector system. The optical system includes an optical device, a first waveguide, and a second waveguide. The optical device is preferably adapted to collect and partition light into a first channel and a second channel of substantially similar light from a substantially singular orientation of the interrogation zone. The first waveguide is preferably adapted to guide the first channel from the optical device to a detector system without substantial interruption. Likewise, the second waveguide is preferably adapted to guide the second channel from the optical device to a detector system without substantial interruption. Preferably, the light of the first channel can be filtered without affecting the light of the second channel, and the light of the second channel can be filtered without affecting the light of the first channel.

Abstract translation: 用于将来自询问区的光引导到检测器系统的光学系统。 光学系统包括光学装置，第一波导和第二波导。 光学装置优选地适于收集并将光分配成第一通道和从询问区域的基本上单一取向的基本相似的光的第二通道。 第一波导优选地适于将第一通道从光学装置引导到检测器系统而没有实质的中断。 类似地，第二波导优选地适于将第二通道从光学装置引导到检测器系统而没有实质的中断。 优选地，可以对第一通道的光进行滤波而不影响第二通道的光，并且可以对第二通道的光进行滤波而不影响第一通道的光。

公开(公告)号：US20060058667A1

公开(公告)日：2006-03-16

申请号：US11229197

申请日：2005-09-15

Applicant: David Lemmerhirt ,  Collin Rich ,  Steven Martin ,  Jeffrey Schox

Inventor： David Lemmerhirt ,  Collin Rich ,  Steven Martin ,  Jeffrey Schox

IPC: A61B8/14

CPC classification number: A61B8/4472 ,  A61B8/00 ,  A61B8/4483 ,  A61B8/483

Abstract: The preferred embodiment of the invention includes a single integrated circuit for a handheld probe of an ultrasound system. The integrated circuit includes a two-dimensional array of at least 512 transducer cells, each transducer cell is adapted to receive a beam signal, generate an ultrasonic beam, detect an ultrasonic echo at multiple locations, and combine the ultrasonic echoes into a single multiplexed echo signal. Each transducer cell includes at least one ultrasonic beam generator and at least four ultrasonic echo detectors. The integrated circuit also includes a series of beam signal leads adapted to carry the beam signals to the transducer cells and a series of echo signal leads adapted to carry the multiplexed echo signals from the transducer cells.

Abstract translation: 本发明的优选实施例包括用于超声系统的手持探针的单个集成电路。 集成电路包括至少512个换能器单元的二维阵列，每个换能器单元适于接收波束信号，产生超声波束，在多个位置检测超声回波，并将超声回波组合成单个多路复用回波 信号。 每个换能器单元包括至少一个超声波束发生器和至少四个超声回波检测器。 集成电路还包括适于将波束信号传送到换能器单元的一系列波束信号引线和适于承载来自换能器单元的多路回波信号的一系列回波信号引线。

公开(公告)号：US20080071149A1

公开(公告)日：2008-03-20

申请号：US11858806

申请日：2007-09-20

Applicant: Collin Rich

Inventor： Collin Rich

IPC: A61B5/00

CPC classification number: A61B8/0833 ,  A61B5/06 ,  A61B6/12 ,  A61B90/36 ,  A61B2017/3413 ,  A61B2034/107 ,  A61B2090/3925

Abstract: The present invention includes a system and a method of representing a medical event. The method includes the steps of collecting 3D information on an event, identifying a non-linear aspect of the event, determining a non-planar slice of the 3D information that represents the non-linear aspect, and outputting the non-planar slice as a representation of the event. The system includes an imaging device for collecting 3D information on an event. The system further includes a processor for identifying a non-linear aspect of the event, determining a non-planar slice of the 3D information that represents the non-linear aspect and outputting the non-planar slice as a representation of the event.

Abstract translation: 本发明包括代表医疗事件的系统和方法。 该方法包括以下步骤：收集关于事件的3D信息，识别事件的非线性方面，确定表示非线性方面的3D信息的非平面切片，以及将非平面切片输出为 表示事件。 该系统包括用于收集关于事件的3D信息的成像装置。 该系统还包括用于识别事件的非线性方面的处理器，确定表示非线性方面的3D信息的非平面切片，并输出非平面切片作为事件的表示。

公开(公告)号：US07403125B2

公开(公告)日：2008-07-22

申请号：US11430591

申请日：2006-05-08

Applicant: Collin Rich

Inventor： Collin Rich

IPC: G08B21/00 ,  B65B1/30 ,  B65B31/00 ,  B67C3/02

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1425 ,  G01N15/1427 ,  G01N29/022 ,  G01N35/00623 ,  G01N2015/0011 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1068

Abstract: The flow cytometry system of the present invention includes a flow channel including an interrogation zone. A light source and a light detector are connected to the interrogation zone, such that a sample flowing through the interrogation zone can be optically analyzed through methods known in the art of flow cytometry. A bubble detector is connected to the flow channel. A controller is connected to the bubble detector and is adapted to perform a predetermined output in response to the detection of a bubble in the flow channel. The predetermined output may include alerting a user as to the presence of a bubble, flagging potentially corrupted data, and ceasing data collection until the interrogation zone is clear of bubbles.

Abstract translation: 本发明的流式细胞术系统包括一个包括询问区的流路。 光源和光检测器连接到询问区，使得流过询问区的样品可以通过流式细胞术技术中已知的方法进行光学分析。 气泡检测器连接到流动通道。 控制器连接到气泡检测器，并且适于响应于流动通道中的气泡的检测而执行预定的输出。 预定的输出可以包括向使用者发出关于气泡的存在，标记可能损坏的数据，以及停止数据收集，直到询问区清除气泡。

公开(公告)号：US20070167812A1

公开(公告)日：2007-07-19

申请号：US11612659

申请日：2006-12-19

Applicant: David Lemmerhirt ,  Collin Rich

Inventor： David Lemmerhirt ,  Collin Rich

IPC: A61B8/14

CPC classification number: B06B1/0292

Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; removing the sacrificial layer S108, followed by the steps of depositing the upper electrode S110 and depositing a protective layer on the upper electrode S112.

Abstract translation: 手持式探头的第一集成电路/换能器装置36包括CMOS电路110和cMUT元件112。 cMUT元件112用于产生超声波束，检测超声回波并输出电信号，而CMOS电路110用于对通过cMUT元件112的操作产生的电信号执行模拟或数字操作。 优选实施例的第一集成电路/换能器装置36的制造方法包括沉积下电极S102的步骤; 沉积牺牲层S 104; 沉积介电层S 106; 去除牺牲层S 108，随后沉积上电极S110并在上电极S 112上沉积保护层的步骤。

公开(公告)号：US20070167811A1

公开(公告)日：2007-07-19

申请号：US11612656

申请日：2006-12-19

Applicant: David Lemmerhirt ,  Collin Rich

Inventor： David Lemmerhirt ,  Collin Rich

IPC: A61B8/14

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; depositing the upper electrode S108; depositing a protective layer on the upper electrode S110; and removing the sacrificial layer S112. In the preferred embodiment, the manufacturing method also includes the step of depositing a sealant layer to seal a cavity between the lower electrode and the upper electrode S114.

Abstract translation: 手持式探头的第一集成电路/换能器装置36包括CMOS电路110和cMUT元件112。 cMUT元件112用于产生超声波束，检测超声回波并输出电信号，而CMOS电路110用于对通过cMUT元件112的操作产生的电信号执行模拟或数字操作。 优选实施例的第一集成电路/换能器装置36的制造方法包括沉积下电极S102的步骤; 沉积牺牲层S 104; 沉积介电层S 106; 沉积上电极S 108; 在上电极S110上沉积保护层; 并去除牺牲层S112。 在优选实施例中，制造方法还包括沉积密封剂层以密封下电极和上电极S114之间的空腔的步骤。

公开(公告)号：US20080092961A1

公开(公告)日：2008-04-24

申请号：US11735456

申请日：2007-04-14

Applicant: Nathaniel Bair ,  Collin Rich

Inventor： Nathaniel Bair ,  Collin Rich

IPC: F04B49/00

CPC classification number: F04B23/04 ,  F04B43/0081 ,  F04B43/12 ,  F04B2201/1201 ,  F04B2205/09 ,  G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T137/0352 ,  Y10T137/0379 ,  Y10T137/0402 ,  Y10T137/85986 ,  Y10T436/115831 ,  Y10T436/117497

Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US20070257215A1

公开(公告)日：2007-11-08

申请号：US11430591

申请日：2006-05-08

Applicant: Collin Rich

Inventor： Collin Rich

IPC: G01N21/85 ,  G01N1/22

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1425 ,  G01N15/1427 ,  G01N29/022 ,  G01N35/00623 ,  G01N2015/0011 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1068

Abstract: The flow cytometry system of the present invention includes a flow channel including an interrogation zone. A light source and a light detector are connected to the interrogation zone, such that a sample flowing through the interrogation zone can be optically analyzed through methods known in the art of flow cytometry. A bubble detector is connected to the flow channel. A controller is connected to the bubble detector and is adapted to perform a predetermined output in response to the detection of a bubble in the flow channel. The predetermined output may include alerting a user as to the presence of a bubble, flagging potentially corrupted data, and ceasing data collection until the interrogation zone is clear of bubbles.

Abstract translation: 本发明的流式细胞术系统包括一个包括询问区的流路。 光源和光检测器连接到询问区，使得流过询问区的样品可以通过流式细胞术技术中已知的方法进行光学分析。 气泡检测器连接到流动通道。 控制器连接到气泡检测器，并且适于响应于流动通道中的气泡的检测而执行预定的输出。 预定的输出可以包括向使用者发出关于气泡的存在，标记可能损坏的数据，以及停止数据收集，直到询问区清除气泡。

公开(公告)号：US20070038088A1

公开(公告)日：2007-02-15

申请号：US11462693

申请日：2006-08-04

Applicant: Collin Rich ,  Clement Goebel

Inventor： Collin Rich ,  Clement Goebel

IPC: A61B8/00

CPC classification number: A61B8/00 ,  A61B8/5276 ,  G01S7/5205 ,  G01S7/52077 ,  G06T7/20 ,  G06T2207/30004

Abstract: An embodiment of the invention includes a method of capturing a series of images of a subject patient with a medical probe having a magnification factor, a frame rate, and an image resolution. The method includes the determining a relative motion between a subject patient and a medical probe and comparing the relative motion to a threshold. The method also includes, the method includes selecting a motion mode for the medical probe and capturing a first series of images of the subject patient with the medical probe in the motion mode if the relative motion is greater than the threshold. The method also includes selecting a stability mode for the medical probe and capturing a second series of images of the subject patient with the medical probe in the stability mode if the relative motion is less than the threshold.

Abstract translation: 本发明的实施例包括利用具有放大因子，帧速率和图像分辨率的医疗探针拍摄受试者患者的一系列图像的方法。 该方法包括确定对象患者和医疗探针之间的相对运动并将相对运动与阈值进行比较。 该方法还包括，如果相对运动大于阈值，则该方法包括：选择用于医疗探针的运动模式并且以运动模式以医疗探针捕获对象患者的第一系列图像。 所述方法还包括如果所述相对运动小于所述阈值，则选择所述医疗探针的稳定性模式并且以所述稳定模式捕获所述医疗探针的所述受试者患者的第二系列图像。