公开(公告)号：US20070212262A1

公开(公告)日：2007-09-13

申请号：US11370714

申请日：2006-03-08

Applicant: Collin Rich

Inventor： Collin Rich

IPC: G01N33/00

CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US20070125436A1

公开(公告)日：2007-06-07

申请号：US11297667

申请日：2005-12-07

Applicant: Collin Rich ,  Steven Martin

Inventor： Collin Rich ,  Steven Martin

IPC: F16L55/04

CPC classification number: F15B1/021 ,  F04B43/12 ,  F15B1/10 ,  F15B21/008 ,  F15B2201/205 ,  F15B2201/215 ,  F15B2201/3151 ,  G01N15/1404 ,  Y10T137/3118 ,  Y10T137/7792

Abstract: A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations with a shallow rolloff slope, and a second fluidic device adapted to attenuate pulsations with a shallow rolloff slope. The first fluidic device and the second fluidic device are connected to the fluidic channel such that they cooperatively attenuate pulsations with a steep rolloff slope. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the pulsation attenuator is arranged, similar a second-order low-pass filter, in the following order: (1) first fluidic resistor, (2) first fluidic capacitor, (3) second fluidic resistor, and (4) second fluidic capacitor.

Abstract translation: 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减具有浅滚降斜率的脉动的第一流体装置，以及适于以浅滚降斜率衰减脉动的第二流体装置。 第一流体装置和第二流体装置连接到流体通道，使得它们以陡峭的滚降斜率协同地衰减脉动。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，按照以下顺序将脉动衰减器类似于二阶低通滤波器：（1）第一流体电阻器，（2）第一流体电容器，（3）第二流体电阻器，和（4）第二流体电阻器 电容器。

公开(公告)号：US20070032734A1

公开(公告)日：2007-02-08

申请号：US11459065

申请日：2006-07-21

Applicant: Nader Najafi ,  Collin Rich

Inventor： Nader Najafi ,  Collin Rich

IPC: A61B5/04

CPC classification number: A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14542 ,  A61B2560/0219 ,  A61N1/37223

Abstract: A method of monitoring physiological parameters for diagnosis and treatment of congestive heart failure in a patient. The method includes implanting at least one sensing device in a cavity of the patient's cardiovascular system, preferably so that the sensing device passes through and is anchored to a septum of the heart and, to minimize the risk of thrombogenicity, a larger portion of the sensing device is located in the right side of the heart and a smaller portion of the sensing device is located in the left side of the heart. Electromagnetic telecommunication and/or wireless powering of the sensing device is performed with an external readout device. The method can be used to perform effective monitoring, management, and tailoring of treatments for patients suffering from congestive heart failure, as well as many other diseases.

Abstract translation: 监测患者充血性心力衰竭诊断和治疗的生理参数的方法。 该方法包括将至少一个感测装置植入患者心血管系统的空腔中，优选地使得感测装置通过并锚定到心脏的隔膜，并且为了使血栓形成的风险最小化，感测的较大部分 装置位于心脏的右侧，感测装置的较小部分位于心脏的左侧。 用外部读出装置执行感测装置的电磁通信和/或无线供电。 该方法可用于对患有充血性心力衰竭的患者以及许多其他疾病进行有效的监测，管理和定制治疗。

公开(公告)号：US07403125B2

公开(公告)日：2008-07-22

申请号：US11430591

申请日：2006-05-08

Applicant: Collin Rich

Inventor： Collin Rich

IPC: G08B21/00 ,  B65B1/30 ,  B65B31/00 ,  B67C3/02

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1425 ,  G01N15/1427 ,  G01N29/022 ,  G01N35/00623 ,  G01N2015/0011 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1068

Abstract: The flow cytometry system of the present invention includes a flow channel including an interrogation zone. A light source and a light detector are connected to the interrogation zone, such that a sample flowing through the interrogation zone can be optically analyzed through methods known in the art of flow cytometry. A bubble detector is connected to the flow channel. A controller is connected to the bubble detector and is adapted to perform a predetermined output in response to the detection of a bubble in the flow channel. The predetermined output may include alerting a user as to the presence of a bubble, flagging potentially corrupted data, and ceasing data collection until the interrogation zone is clear of bubbles.

Abstract translation: 本发明的流式细胞术系统包括一个包括询问区的流路。 光源和光检测器连接到询问区，使得流过询问区的样品可以通过流式细胞术技术中已知的方法进行光学分析。 气泡检测器连接到流动通道。 控制器连接到气泡检测器，并且适于响应于流动通道中的气泡的检测而执行预定的输出。 预定的输出可以包括向使用者发出关于气泡的存在，标记可能损坏的数据，以及停止数据收集，直到询问区清除气泡。

公开(公告)号：US20070167812A1

公开(公告)日：2007-07-19

申请号：US11612659

申请日：2006-12-19

Applicant: David Lemmerhirt ,  Collin Rich

Inventor： David Lemmerhirt ,  Collin Rich

IPC: A61B8/14

CPC classification number: B06B1/0292

Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; removing the sacrificial layer S108, followed by the steps of depositing the upper electrode S110 and depositing a protective layer on the upper electrode S112.

Abstract translation: 手持式探头的第一集成电路/换能器装置36包括CMOS电路110和cMUT元件112。 cMUT元件112用于产生超声波束，检测超声回波并输出电信号，而CMOS电路110用于对通过cMUT元件112的操作产生的电信号执行模拟或数字操作。 优选实施例的第一集成电路/换能器装置36的制造方法包括沉积下电极S102的步骤; 沉积牺牲层S 104; 沉积介电层S 106; 去除牺牲层S 108，随后沉积上电极S110并在上电极S 112上沉积保护层的步骤。

公开(公告)号：US20070167811A1

公开(公告)日：2007-07-19

申请号：US11612656

申请日：2006-12-19

Applicant: David Lemmerhirt ,  Collin Rich

Inventor： David Lemmerhirt ,  Collin Rich

IPC: A61B8/14

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; depositing the upper electrode S108; depositing a protective layer on the upper electrode S110; and removing the sacrificial layer S112. In the preferred embodiment, the manufacturing method also includes the step of depositing a sealant layer to seal a cavity between the lower electrode and the upper electrode S114.

Abstract translation: 手持式探头的第一集成电路/换能器装置36包括CMOS电路110和cMUT元件112。 cMUT元件112用于产生超声波束，检测超声回波并输出电信号，而CMOS电路110用于对通过cMUT元件112的操作产生的电信号执行模拟或数字操作。 优选实施例的第一集成电路/换能器装置36的制造方法包括沉积下电极S102的步骤; 沉积牺牲层S 104; 沉积介电层S 106; 沉积上电极S 108; 在上电极S110上沉积保护层; 并去除牺牲层S112。 在优选实施例中，制造方法还包括沉积密封剂层以密封下电极和上电极S114之间的空腔的步骤。

公开(公告)号：US20080092961A1

公开(公告)日：2008-04-24

申请号：US11735456

申请日：2007-04-14

Applicant: Nathaniel Bair ,  Collin Rich

Inventor： Nathaniel Bair ,  Collin Rich

IPC: F04B49/00

CPC classification number: F04B23/04 ,  F04B43/0081 ,  F04B43/12 ,  F04B2201/1201 ,  F04B2205/09 ,  G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T137/0352 ,  Y10T137/0379 ,  Y10T137/0402 ,  Y10T137/85986 ,  Y10T436/115831 ,  Y10T436/117497

Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US20070257215A1

公开(公告)日：2007-11-08

申请号：US11430591

申请日：2006-05-08

Applicant: Collin Rich

Inventor： Collin Rich

IPC: G01N21/85 ,  G01N1/22

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1425 ,  G01N15/1427 ,  G01N29/022 ,  G01N35/00623 ,  G01N2015/0011 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1068

Abstract: The flow cytometry system of the present invention includes a flow channel including an interrogation zone. A light source and a light detector are connected to the interrogation zone, such that a sample flowing through the interrogation zone can be optically analyzed through methods known in the art of flow cytometry. A bubble detector is connected to the flow channel. A controller is connected to the bubble detector and is adapted to perform a predetermined output in response to the detection of a bubble in the flow channel. The predetermined output may include alerting a user as to the presence of a bubble, flagging potentially corrupted data, and ceasing data collection until the interrogation zone is clear of bubbles.

Abstract translation: 本发明的流式细胞术系统包括一个包括询问区的流路。 光源和光检测器连接到询问区，使得流过询问区的样品可以通过流式细胞术技术中已知的方法进行光学分析。 气泡检测器连接到流动通道。 控制器连接到气泡检测器，并且适于响应于流动通道中的气泡的检测而执行预定的输出。 预定的输出可以包括向使用者发出关于气泡的存在，标记可能损坏的数据，以及停止数据收集，直到询问区清除气泡。

公开(公告)号：US20070038088A1

公开(公告)日：2007-02-15

申请号：US11462693

申请日：2006-08-04

Applicant: Collin Rich ,  Clement Goebel

Inventor： Collin Rich ,  Clement Goebel

IPC: A61B8/00

CPC classification number: A61B8/00 ,  A61B8/5276 ,  G01S7/5205 ,  G01S7/52077 ,  G06T7/20 ,  G06T2207/30004

Abstract: An embodiment of the invention includes a method of capturing a series of images of a subject patient with a medical probe having a magnification factor, a frame rate, and an image resolution. The method includes the determining a relative motion between a subject patient and a medical probe and comparing the relative motion to a threshold. The method also includes, the method includes selecting a motion mode for the medical probe and capturing a first series of images of the subject patient with the medical probe in the motion mode if the relative motion is greater than the threshold. The method also includes selecting a stability mode for the medical probe and capturing a second series of images of the subject patient with the medical probe in the stability mode if the relative motion is less than the threshold.

Abstract translation: 本发明的实施例包括利用具有放大因子，帧速率和图像分辨率的医疗探针拍摄受试者患者的一系列图像的方法。 该方法包括确定对象患者和医疗探针之间的相对运动并将相对运动与阈值进行比较。 该方法还包括，如果相对运动大于阈值，则该方法包括：选择用于医疗探针的运动模式并且以运动模式以医疗探针捕获对象患者的第一系列图像。 所述方法还包括如果所述相对运动小于所述阈值，则选择所述医疗探针的稳定性模式并且以所述稳定模式捕获所述医疗探针的所述受试者患者的第二系列图像。

公开(公告)号：US20070224684A1

公开(公告)日：2007-09-27

申请号：US11387186

申请日：2006-03-22

Applicant: David Olson ,  Nathaniel Bair ,  Richard Fisher ,  Steve Martin ,  Collin Rich

Inventor： David Olson ,  Nathaniel Bair ,  Richard Fisher ,  Steve Martin ,  Collin Rich

IPC: G01N33/48

CPC classification number: G01N15/1459

Abstract: A first preferred embodiment includes a flow cytometer with a fluidic system to draw a sample fluid into an interrogation zone, a light source to emit light toward the sample fluid in the interrogation zone, an optic system to collect and detect at least one of a scattered light and a fluorescent light from the interrogation zone, and a processor. The flow cytometer, if properly boxed and labeled, complies with the parcel post requirements of the United States Postal Service. A second preferred embodiment includes the method of supplying a flow cytometer by shipping the flow cytometer via the United States Postal Service. A third preferred embodiment includes the method of servicing a flow cytometer by receiving the flow cytometer from a user via the United States Postal Service and servicing the flow cytometer.

Abstract translation: 第一优选实施方案包括流式细胞仪，其具有将样品流体吸入询问区的流体系统，向询问区中的样品流体发光的光源，用于收集和检测散射的至少一种的光学系统 来自询问区的光和荧光灯以及处理器。 流式细胞仪如果正确装箱和贴标签符合美国邮政局的包裹邮寄要求。 第二个优选实施方案包括通过美国邮政局运送流式细胞仪提供流式细胞仪的方法。 第三优选实施方案包括通过经由美国邮政局从用户接收流式细胞仪并服务于流式细胞仪来服务流式细胞仪的方法。