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    Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems
    2.
    发明授权
    Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 有权

    公开(公告)号：US09382521B2

    公开(公告)日：2016-07-05

    申请号：US13848070

    申请日：2013-03-21

    Applicant: DSM IP Assets B.V.

    Inventor： James G. Metz ,  Jerry M. Kuner ,  James Casey Lippmeier

    IPC: C12N9/10 ,  C12N9/00 ,  C12N15/82 ,  C12P7/64

    CPC classification number: C12N9/1029 ,  C12N9/93 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472 ,  Y02P20/52

    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.

    POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS
    3.
    发明申请
    POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 有权
    使用多不饱和脂多糖合成酶系统进行异构体生物聚合脂肪酸生产

    公开(公告)号：US20140289904A1

    公开(公告)日：2014-09-25

    申请号：US13848070

    申请日：2013-03-21

    Applicant: DSM IP Assets B.V.

    Inventor： James G. METZ ,  Jerry M. Kuner ,  James Casey Lippmeier

    IPC: C12N9/10 ,  C12N15/82

    CPC classification number: C12N9/1029 ,  C12N9/93 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472 ,  Y02P20/52

    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.

    Abstract translation: 公开了新型酰基辅酶A合成酶和新型酰基转移酶，编码该酰基转移酶的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用 一样。 还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物体表达的脂肪酸合酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加生物体中丙二酰辅酶A的水平，以及 一方面抑制KASII或KASIII。 除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

    PUFA Polyketide Synthase Systems and Uses Thereof
    4.
    发明申请
    PUFA Polyketide Synthase Systems and Uses Thereof 审中-公开
    PUFA聚酮系统及其用途

    公开(公告)号：US20140053299A1

    公开(公告)日：2014-02-20

    申请号：US13771840

    申请日：2013-02-20

    Applicant: DSM IP Assets B.V.

    Inventor： James G. METZ ,  James H. Flatt ,  Jerry M. Kuner ,  William R. Barclay

    IPC: C12N15/82

    CPC classification number: C12N15/8247 ,  C07K14/21 ,  C07K14/28 ,  C07K14/405 ,  C12N15/52 ,  C12P7/6427 ,  C12P7/6472

    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

    Abstract translation: 公开了来自裂殖壶菌的完全多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统及其生物活性片段及其同源物。 更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用 本文公开的PUFA PKS系统。 本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

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