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公开(公告)号:US09024114B2
公开(公告)日:2015-05-05
申请号:US13143491
申请日:2010-01-06
申请人: Dale Carlson , Francisco Jose Lima Aragao , Carlos Alberto Arrabal Arias , Luiz Louzano , Bruce M. Luzzi , Tim Malefyt , Elibio Leopoldo Rech Filho , Siyuan Tan , Adolfo Ulbrich , Tadashi Yotsumoto , Ute Linemann
发明人: Dale Carlson , Francisco Jose Lima Aragao , Carlos Alberto Arrabal Arias , Luiz Louzano , Bruce M. Luzzi , Tim Malefyt , Elibio Leopoldo Rech Filho , Siyuan Tan , Adolfo Ulbrich , Tadashi Yotsumoto , Ute Linemann
CPC分类号: A01H5/10 , A01H1/04 , C12N15/8274 , C12N15/8275 , C12Q1/6895
摘要: Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts tolerance to an AHAS-inhibiting herbicide are provided. The event 127 soybean plants having the event 127 nucleic acid molecule at the identified chromosomal location may comprise genomic/transgene junctions having at least the nucleic acid sequence of SEQ ID NO: 5 and/or 6. The characterization of the genomic insertion site of the event 127 provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event 127 soybean plants are provided.
摘要翻译: 提供了与转基因AHAS抑制除草剂抗性大豆植物相关的组合物和方法。 提供了具有突变的AHAS编码序列的127种大豆植物,其赋予对AHAS抑制性除草剂的耐受性。 在确定的染色体位置处具有事件127核酸分子的127个大豆植物的事件可以包含至少具有SEQ ID NO:5和/或6的核酸序列的基因组/转基因接头。 事件127提供增强的育种效率,并且能够使用分子标记来跟踪育种种群中的转基因插入物及其后代。 提供用于鉴定,检测和使用事件127种大豆植物的各种方法和组合物。
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公开(公告)号:US20120117676A1
公开(公告)日:2012-05-10
申请号:US13143491
申请日:2010-01-06
申请人: Dale Carlson , Francisco Jose Lima Aragao , Carlos Alberto Arrabal Arias , Luiz Louzano , Bruce M. Luzzi , Tim Malefyt , Elibio Leopoldo Rech Filho , Siyuan Tan , Adolfo Ulbrich , Tadashi Yotsumoto , Ute Linemann
发明人: Dale Carlson , Francisco Jose Lima Aragao , Carlos Alberto Arrabal Arias , Luiz Louzano , Bruce M. Luzzi , Tim Malefyt , Elibio Leopoldo Rech Filho , Siyuan Tan , Adolfo Ulbrich , Tadashi Yotsumoto , Ute Linemann
IPC分类号: A01N43/54 , A01H5/00 , C07H21/04 , C12Q1/68 , A01N61/00 , A01H5/10 , G01N33/566 , C07K17/00 , C40B40/06 , C40B40/10 , C12N15/11 , A01H1/02
CPC分类号: A01H5/10 , A01H1/04 , C12N15/8274 , C12N15/8275 , C12Q1/6895
摘要: Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts tolerance to an AHAS-inhibiting herbicide are provided. The event 127 soybean plants having the event 127 nucleic acid molecule at the identified chromosomal location may comprise genomic/transgene junctions having at least the nucleic acid sequence of SEQ ID NO: 5 and/or 6. The characterization of the genomic insertion site of the event 127 provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event 127 soybean plants are provided.
摘要翻译: 提供了与转基因AHAS抑制除草剂抗性大豆植物相关的组合物和方法。 提供了具有突变的AHAS编码序列的127种大豆植物,其赋予对AHAS抑制性除草剂的耐受性。 在确定的染色体位置处具有事件127核酸分子的127个大豆植物的事件可以包含至少具有SEQ ID NO:5和/或6的核酸序列的基因组/转基因接头。 事件127提供增强的育种效率,并且能够使用分子标记来跟踪育种种群中的转基因插入物及其后代。 提供用于鉴定,检测和使用事件127种大豆植物的各种方法和组合物。
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公开(公告)号:US20110301073A1
公开(公告)日:2011-12-08
申请号:US13068735
申请日:2011-05-17
申请人: Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人: Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
IPC分类号: A61K38/02 , C07K19/00 , C12N9/16 , C12N5/071 , C12N5/04 , C12N1/21 , C07H21/00 , C12N1/19 , C12N5/10 , C12N1/15 , C12N1/13 , C12N1/11 , C07K14/00 , C12N1/16
CPC分类号: C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译: 本文公开了编码包含新的DNA结合结构域(包括TALE DNA结合结构域)的多肽,多核苷酸,细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号:US20110082078A1
公开(公告)日:2011-04-07
申请号:US12658258
申请日:2010-02-04
申请人: Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
发明人: Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
CPC分类号: C07K14/4702 , A61K38/00
摘要: Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
摘要翻译: 本文公开了通过调节GDNF基因表达的内源性NT-3来治疗神经病的方法和组合物。
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公开(公告)号:US08551945B2
公开(公告)日:2013-10-08
申请号:US12658258
申请日:2010-02-04
申请人: Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
发明人: Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
IPC分类号: A61K38/00 , A61K38/28 , A61P3/10 , A61P7/12 , A61P25/02 , C12N5/00 , C12N5/02 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H21/04
CPC分类号: C07K14/4702 , A61K38/00
摘要: Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
摘要翻译: 本文公开了通过调节GDNF基因表达的内源性NT-3来治疗神经病的方法和组合物。
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公开(公告)号:US08586526B2
公开(公告)日:2013-11-19
申请号:US13068735
申请日:2011-05-17
申请人: Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人: Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
CPC分类号: C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译: 本文公开了编码包含新的DNA结合结构域(包括TALE DNA结合结构域)的多肽,多核苷酸,细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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