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公开(公告)号：US10791730B2
公开(公告)日：2020-10-06
申请号：US15400022
申请日：2017-01-06
发明人： Anna Gosiewska , Anthony J. Kihm
IPC分类号： A01N1/02
摘要： This invention provides for compositions for cryopreservation of human umbilical cord tissue-derived cells. The cryopreservation compositions may comprise: (a) amino acids; (b) vitamins; (c) inorganic salts; and (d) DMSO, sucrose, mannitol, and lactobionic acid. The invention also provides for kits comprising the composition and human umbilical cord tissue-derived cells and methods of cryopreserving the cells, which utilize the compositions.
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公开(公告)号：US20170202212A1
公开(公告)日：2017-07-20
申请号：US15400022
申请日：2017-01-06
发明人： Anna Gosiewska , Anthony J. Kihm
IPC分类号： A01N1/02
摘要： This invention provides for compositions for cryopreservation of human umbilical cord tissue-derived cells. The cryopreservation compositions may comprise: (a) amino acids; (b) vitamins; (c) inorganic salts; and (d) DMSO, sucrose, mannitol, and lactobionic acid. The invention also provides for kits comprising the composition and human umbilical cord tissue-derived cells and methods of cryopreserving the cells, which utilize the compositions.
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公开(公告)号：US20170143770A1
公开(公告)日：2017-05-25
申请号：US15362453
申请日：2016-11-28
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
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4.发明申请公开(公告)号：US20170065644A1
公开(公告)日：2017-03-09
申请号：US15357449
申请日：2016-11-21
CPC分类号： A61K35/51 , A61K9/0019 , A61K38/1841 , A61K38/1858 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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公开(公告)号：US11000554B2
公开(公告)日：2021-05-11
申请号：US16291784
申请日：2019-03-04
发明人： Anthony J. Kihm , Ian R. Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/074 , C12N5/073 , A61K35/50 , A61K35/51 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/12
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
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6.发明申请公开(公告)号：US20190105352A9
公开(公告)日：2019-04-11
申请号：US15357449
申请日：2016-11-21
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
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公开(公告)号：US10039793B2
公开(公告)日：2018-08-07
申请号：US15362453
申请日：2016-11-28
IPC分类号： C12N5/073 , A61K35/50 , A61K35/51 , A61K38/18 , A61K38/20 , A61K38/19 , A61K38/27 , C12N5/0735
摘要： Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
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8.发明申请公开(公告)号：US20170239299A1
公开(公告)日：2017-08-24
申请号：US15443602
申请日：2017-02-27
发明人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
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公开(公告)号：US10413571B2
公开(公告)日：2019-09-17
申请号：US15238993
申请日：2016-08-17
摘要： Isolated or purified mammalian kidney-derived cell populations from mammalian kidney tissue are provided. Methods are provided for the isolation and purification of the mammalian kidney-derived cell population. Methods for treating kidney disease are provided by administration of the isolated or purified mammalian kidney-derived cell population to a mammalian subject.
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10.发明授权公开(公告)号：US10383898B2
公开(公告)日：2019-08-20
申请号：US15443733
申请日：2017-02-27
发明人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/073 , C12N5/074 , A61K35/51 , A61K35/50 , A61K45/06 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A01N1/02 , A61K35/12
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
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