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公开(公告)号：US07977464B2
公开(公告)日：2011-07-12
申请号：US12141667
申请日：2008-06-18
申请人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
发明人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
摘要翻译： 公开了含有至少一种衍生自对人TNFα具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 还公开了编码抗体分子链，载体，转化的宿主细胞的链DNA序列以及抗体分子在治疗TNFα介导的疾病中的用途。
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公开(公告)号：US07186820B2
公开(公告)日：2007-03-06
申请号：US09949559
申请日：2001-09-10
申请人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
发明人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
IPC分类号： C07H21/04 , C12P21/04 , C12N1/20 , C12N15/00 , C12P21/08 , C07K16/00 , A61K39/395 , C12N15/02
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
摘要翻译： 公开了含有至少一种衍生自对人TNFα具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化宿主细胞的链DNA序列和抗体分子在治疗由TNFα介导的疾病中的用途。
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公开(公告)号：US07012135B2
公开(公告)日：2006-03-14
申请号：US09875221
申请日：2001-06-06
申请人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
发明人： Diljeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
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公开(公告)号：US07402662B2
公开(公告)日：2008-07-22
申请号：US11374231
申请日：2006-03-13
申请人： Dilijeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
发明人： Dilijeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
摘要翻译： 公开了含有至少一种衍生自对人TNFα具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化宿主细胞的链DNA序列和抗体分子在治疗由TNFα介导的疾病中的用途。
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5.发明授权Method for expressing recombinant genes in bacteria in absence of antibiotic selection 失效在没有抗生素选择的情况下在细菌中表达重组基因的方法
公开(公告)号：US5928903A
公开(公告)日：1999-07-27
申请号：US411778
申请日：1995-03-14
CPC分类号： C12N15/70 , C07K16/461 , C07K2317/24 , C07K2319/035 , C07K2319/33 , C07K2319/55
摘要： The invention provides a method for the expression of recombinant molecules in bacterial hosts in a defined medium in the absence of antibiotic selection. The method uses an expression vector comprising a regulatable promoter by which the production of foreign proteins may be controlled during the growth phase of the culture, an origin of replication maintaining medium vector copy number and a transcriptional terminator.
摘要翻译： PCT No.PCT / GB93 / 01547 Sec。 371日期：1995年3月14日 102（e）1995年3月14日PCT 1993年7月22日PCT公布。 公开号WO94 / 02607 日期1994年2月3日本发明提供了在没有抗生素选择的情况下，在限定的培养基中在细菌宿主中表达重组分子的方法。 该方法使用包含可调节启动子的表达载体，通过该表达载体可以在培养物的生长阶段，复制起点保持培养基载体拷贝数和转录终止子来控制外源蛋白的产生。
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公开(公告)号：US07718157B1
公开(公告)日：2010-05-18
申请号：US10049670
申请日：2000-08-16
申请人： Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall , Michael Anthony William Eaton , Timothy John Norman , David Parker
发明人： Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall , Michael Anthony William Eaton , Timothy John Norman , David Parker
CPC分类号： C12N15/87 , A61K47/6801 , A61K47/6849 , A61K47/6907 , A61K48/00
摘要： Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
摘要翻译： 描述了靶向脂质和脂质颗粒，其是多极脂质的组装体，靶向分子例如抗体和聚阴离子。 脂质特别用于在体外，特别是体内将生物活性物质例如核酸递送至细胞。
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公开(公告)号：US06583301B1
公开(公告)日：2003-06-24
申请号：US09646766
申请日：2000-11-20
申请人： Michael Anthony William Eaton , Timothy John Norman , David Parker , Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall
发明人： Michael Anthony William Eaton , Timothy John Norman , David Parker , Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall
IPC分类号： C07C23100
CPC分类号： A61K9/1272 , A61K31/225 , A61K31/685 , A61K47/543 , A61K47/6929 , C07C235/10 , C07C235/12 , C07C237/10 , C07C271/20
摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
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公开(公告)号：US06284488B1
公开(公告)日：2001-09-04
申请号：US09335706
申请日：1999-06-18
IPC分类号： C12P2104
CPC分类号： C12N15/70 , C07K16/461 , C07K2317/24 , C07K2319/035 , C07K2319/33 , C07K2319/55
摘要： A method for expressing recombinant molecules in bacterial hosts in a defined medium in the absence of antibiotic selection is disclosed. The method uses an expression vector comprising a regulatable promoter by which the production of foreign proteins may be controlled during the growth phase of the culture, and origin of replication maintaining medium vector copy number and a transcriptional promoter.
摘要翻译： 公开了在不存在抗生素选择的情况下，在限定的培养基中在细菌宿主中表达重组分子的方法。 该方法使用包含可调节启动子的表达载体，通过该表达载体可以在培养物的生长阶段期间控制外源蛋白的产生，并保留复制起点保持培养基载体拷贝数和转录启动子。
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公开(公告)号：US07531676B2
公开(公告)日：2009-05-12
申请号：US11189133
申请日：2005-07-26
申请人： Michael Anthony William Eaton , Timothy John Norman , David Parker , Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall
发明人： Michael Anthony William Eaton , Timothy John Norman , David Parker , Terence Seward Baker , Andrew Neil Charles Weir , Catherine Fiona Catterall
IPC分类号： C07C233/00
CPC分类号： A61K9/1272 , A61K31/225 , A61K31/685 , A61K47/543 , A61K47/6929 , C07C235/10 , C07C235/12 , C07C237/10 , C07C271/20
摘要： Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
摘要翻译： 描述了能够与聚阴离子形成复合物的双相脂质。 脂质包含连接到疏水骨架和亲水尾部的阳离子头，并且能够自组装以在水溶液中形成稳定的络合物。 脂质特别用于在体外，特别是体内将生物活性物质例如核酸递送至细胞。
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公开(公告)号：US5665866A
公开(公告)日：1997-09-09
申请号：US367313
申请日：1995-03-14
IPC分类号： C07K16/30 , C07K16/46 , C12N15/13 , C12N15/69 , C12N15/70 , C12P21/02 , C12P21/08 , C07K16/00
CPC分类号： C07K16/3007 , C07K16/3046 , C07K16/461 , C12N15/69 , C12N15/70 , C12P21/02 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： This invention relates to a process for obtaining antibodies in soluble and correctly folded and assembled form. It comprises a step to raise the temperature at a time in the process selected to facilitate the subsequent isolation of soluble, correctly folded and assembled antibody, substantially free of other antibody-related material. The operating temperature may be raised at any stage in the microbial fermentation or eukaryotic cell culture, or at any stage during extraction and purification of the antibodies.
摘要翻译： PCT No.PCT / GB93 / 01548 Sec。 371日期：1995年3月14日 102（e）1995年3月14日PCT 1993年7月22日PCT公布。 出版物WO94 / 02608 日期1994年2月3日本发明涉及一种获得可溶性和正确折叠和组装形式的抗体的方法。 其包括在选择的方法中一次升高温度的步骤，以便于随后分离可溶的，正确折叠和组装的抗体，基本上不含其它抗体相关材料。 在微生物发酵或真核细胞培养中的任何阶段，或在抗体的提取和纯化期间的任何阶段，操作温度可以升高。
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