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公开(公告)号：US11826028B2
公开(公告)日：2023-11-28
申请号：US16897328
申请日：2020-06-10
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Sridevi Dhanaraj , Ashley DeAnglis , Salim Ghodbane
CPC classification number: A61B17/0057 , A61L24/10 , A61L31/005 , A61L31/047 , A61L31/06 , A61L31/125 , A61L31/146 , A61L31/148 , A61B2017/00004 , A61B2017/0065 , A61L2400/04
Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.
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公开(公告)号：US20220331475A1
公开(公告)日：2022-10-20
申请号：US17667787
申请日：2022-02-09
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Thomas Weindl , Benjamin D. Fitz , Gerard Llanos , Guanghui Zhang , Yi-Lan Wang , Meng Deng
Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
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公开(公告)号：US20220023488A1
公开(公告)日：2022-01-27
申请号：US16934982
申请日：2020-07-21
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Gerard Llanos , Thomas Weindl , Sai Veruva
Abstract: The present invention is directed to medical devices having a first porous substrate layer with at least a surface coating thereon of a first co-reactive component and a second substrate layer with at least a surface coating layer of a second co-reactive component that reacts with the first co-reactive component, and a removable barrier layer positioned between the first substrate layer and second substrate layer and in contact with said first substrate layer and said second substrate layer.
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公开(公告)号：US20210393245A1
公开(公告)日：2021-12-23
申请号：US16897328
申请日：2020-06-10
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Sridevi Dhanaraj , Ashley DeAnglis , Salim Ghodbane
Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.
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