Methods and apparatus for image-guided ultrasound delivery of compounds
through the blood-brain barrier
    1.
    发明授权
    Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier 失效
    图像引导超声传递化合物通过血脑屏障的方法和装置

    公开(公告)号:US5752515A

    公开(公告)日:1998-05-19

    申请号:US711289

    申请日:1996-08-21

    摘要: Image-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging, to confirm the location of that change. A compound, e.g., a neuropharmaceutical, in the patient's bloodstream is delivered to the confirmed location by applying ultrasound to effect opening of the blood-brain barrier at that location and, thereby, to induce uptake of the compound there.

    摘要翻译: 图像引导方法和装置,用于超声传递化合物通过血脑屏障到达脑中的选定位置,在脑中的选定位置,并应用超声波在该位置处的组织和/或流体中影响可通过成像检测的变化 。 在所选位置附近的脑部的至少一部分成像,例如通过磁共振成像,以确认该变化的位置。 患者血液中的化合物(例如神经药物)通过施加超声波而被递送到确认的位置,以在该位置处实现血脑屏障的打开,从而诱导在那里的化合物摄取。

    Impedance matching for ultrasound phased array elements
    3.
    发明授权
    Impedance matching for ultrasound phased array elements 有权
    用于超声相控阵列元件的阻抗匹配

    公开(公告)号:US09387515B2

    公开(公告)日:2016-07-12

    申请号:US11600301

    申请日:2006-11-15

    申请人: Kullervo Hynynen

    发明人: Kullervo Hynynen

    IPC分类号: B06B1/06

    摘要: A system includes a transducer configured to emit ultrasound in response to receiving an electrical signal from a driving circuit. The transducer includes a first dimension that determines a frequency of the ultrasound and a second dimension that determines an impedance of the transducer. The frequency is independent of the second dimension.

    摘要翻译: 系统包括响应于从驱动电路接收电信号而被配置为发射超声的换能器。 换能器包括确定超声频率的第一维度和确定换能器阻抗的第二维度。 频率与第二维无关。

    Shear mode therapeutic ultrasound
    4.
    发明授权
    Shear mode therapeutic ultrasound 有权
    剪切模式治疗超声

    公开(公告)号:US07344509B2

    公开(公告)日:2008-03-18

    申请号:US10822019

    申请日:2004-04-09

    IPC分类号: A61H1/00

    摘要: A method of delivering ultrasound signals using shear waves includes applying a portion of at least a first ultrasound beam to a subject at at least a first incident angle relative to the surface of the subject to induce shear waves in the subject, energy in the shear waves forming a substantial part of energy of first ultrasound waves at a desired region in the subject at a therapeutic level.

    摘要翻译: 使用剪切波输送超声信号的方法包括:至少第一超声波束的一部分相对于受试者的表面以至少第一入射角施加到受试者,以在受试者中引起剪切波,剪切波中的能量 在治疗水平上在受试者的期望区域形成第一超声波的大部分能量。

    Phased array ultrasound for cardiac ablation
    5.
    发明申请
    Phased array ultrasound for cardiac ablation 审中-公开
    心脏消融相控阵超声

    公开(公告)号:US20060052706A1

    公开(公告)日:2006-03-09

    申请号:US11208353

    申请日:2005-08-19

    IPC分类号: A61B8/14

    摘要: A system is provided for performing ablation of target tissue. The system includes an ultrasound phased array having a plurality of ultrasonic transducers and drive circuitry that is configured to generate signals that cause the ultrasonic transducers to focus ultrasound radiation at the target tissue. The system also includes a diagnostic system configured to collect diagnostic data that is indicative of a condition of the target tissue and computational circuitry that is configured to control the drive circuitry based on the diagnostic data.

    摘要翻译: 提供用于进行靶组织消融的系统。 该系统包括具有多个超声波换能器和驱动电路的超声相控阵,该超声换能器和驱动电路经配置以产​​生使超声波换能器将超声辐射聚焦在靶组织上的信号。 该系统还包括被配置为收集指示目标组织的状况的诊断数据和被配置为基于诊断数据来控制驱动电路的计算电路的诊断系统。

    FOCUSED ULTRASOUND SYSTEM
    10.
    发明申请
    FOCUSED ULTRASOUND SYSTEM 有权
    聚焦超声系统

    公开(公告)号:US20100125192A1

    公开(公告)日:2010-05-20

    申请号:US12618824

    申请日:2009-11-16

    IPC分类号: A61B5/055 A61N7/00

    摘要: A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.

    摘要翻译: 聚焦超声系统包括配置成朝向受试者发射聚焦超声能量的超声换能器,以及配置成定位超声换能器以定位目标位置内的聚焦超声能量的定位系统。 定位系统包括驱动装置,用于沿着至少一个运动轴平移超声换能器和马达控制器以控制驱动装置。 聚焦超声系统还包括连接到电机控制器的控制系统,其被编程为从成像系统接收成像/位置数据,基于成像/位置数据确定目标位置的位置坐标,并且记录 目标位置与定位系统。 位置坐标通过输入信号发送到电动机控制器,使得电动机控制器控制驱动装置以平移超声换能器。