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    Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
    1.
    发明授权
    Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier 失效
    图像引导超声传递化合物通过血脑屏障的方法和装置

    公开(公告)号：US5752515A

    公开(公告)日：1998-05-19

    申请号：US711289

    申请日：1996-08-21

    申请人： Ferenc A. Jolesz ,  Kullervo Hynynen

    发明人： Ferenc A. Jolesz ,  Kullervo Hynynen

    IPC分类号： A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/22 ,  A61B19/00 ,  A61N7/00 ,  A61B5/00

    CPC分类号： A61M37/0092 ,  A61B5/055 ,  A61B8/0808 ,  A61N7/00 ,  A61B2017/22008 ,  A61B2017/22028 ,  A61B2090/374 ,  A61B2090/376 ,  A61B8/08 ,  A61B8/481

    摘要： Image-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging, to confirm the location of that change. A compound, e.g., a neuropharmaceutical, in the patient's bloodstream is delivered to the confirmed location by applying ultrasound to effect opening of the blood-brain barrier at that location and, thereby, to induce uptake of the compound there.

    摘要翻译： 图像引导方法和装置，用于超声传递化合物通过血脑屏障到达脑中的选定位置，在脑中的选定位置，并应用超声波在该位置处的组织和/或流体中影响可通过成像检测的变化 。 在所选位置附近的脑部的至少一部分成像，例如通过磁共振成像，以确认该变化的位置。 患者血液中的化合物（例如神经药物）通过施加超声波而被递送到确认的位置，以在该位置处实现血脑屏障的打开，从而诱导在那里的化合物摄取。

    Use of magnetic field of magnetic resonance imaging devices as the source of the magnetic field of electromagnetic transducers
    5.
    发明授权
    Use of magnetic field of magnetic resonance imaging devices as the source of the magnetic field of electromagnetic transducers 失效
    磁共振成像装置的磁场作为电磁传感器磁场的来源使用

    公开(公告)号：US5131392A

    公开(公告)日：1992-07-21

    申请号：US479415

    申请日：1990-02-13

    申请人： Ferenc A. Jolesz ,  Peter D. Jakab

    发明人： Ferenc A. Jolesz ,  Peter D. Jakab

    IPC分类号： A61B5/055 ,  A61B17/22 ,  A61B19/00 ,  B06B1/04 ,  G01R33/28 ,  G10K15/04

    CPC分类号： G10K15/043 ,  A61B17/22004 ,  A61B17/2256 ,  B06B1/04 ,  G01R33/28 ,  A61B2090/374

    摘要： A magnetic resonance imaging device is used to provide the static magnetic field for transducers. The static magnetic field in combination with electric current pulses energize phased arrayed transducers to generate acoustic waves or motion. The transducers can be arranged in the magnetic resonance imaging device static magnetic field to focus acoustic shock waves for the disintegration of target calculi in extracorporeal shock wave lithotripsy. The magnetic resonance imaging device is also used for target localization and monitoring of the mechanical energy effects of the transducers. In further embodiments, the transducers include coils that are implantable within a subject body and can be moved in the magnetic resonance imaging device's static magnetic field.

    摘要翻译： 磁共振成像装置用于为换能器提供静态磁场。 与电流脉冲相结合的静磁场激励相控阵列换能器以产生声波或运动。 传感器可以布置在磁共振成像设备的静磁场中，以将声波冲击波聚焦在体外冲击波碎石术中目标结石的分解。 磁共振成像装置还用于目标定位和监测换能器的机械能量效应。 在另外的实施例中，换能器包括可植入物体内并可在磁共振成像装置的静磁场中移动的线圈。

    Elastomeric actuator devices for magnetic resonance imaging
    7.
    发明授权
    Elastomeric actuator devices for magnetic resonance imaging 失效
    用于磁共振成像的弹性致动器装置

    公开(公告)号：US07362889B2

    公开(公告)日：2008-04-22

    申请号：US10291866

    申请日：2002-11-08

    申请人： Steven Dubowsky ,  Moustapha Hafez ,  Ferenc A. Jolesz ,  Daniel F. Kacher ,  Matthew Lichter ,  Peter Weiss ,  Andreas Wingert

    发明人： Steven Dubowsky ,  Moustapha Hafez ,  Ferenc A. Jolesz ,  Daniel F. Kacher ,  Matthew Lichter ,  Peter Weiss ,  Andreas Wingert

    IPC分类号： G06K9/00

    CPC分类号： G01R33/28

    摘要： The present invention is directed to devices and systems used in magnetic imaging environments that include an actuator device having an elastomeric dielectric film with at least two electrodes, and a frame attached to the actuator device. The frame can have a plurality of configurations including, such as, for example, at least two members that can be, but not limited to, curved beams, rods, plates, or parallel beams. These rigid members can be coupled to flexible members such as, for example, links wherein the frame provides an elastic restoring force. The frame preferably provides a linear actuation force characteristic over a displacement range. The linear actuation force characteristic is defined as ±20% and preferably 10% over a displacement range. The actuator further includes a passive element disposed between the flexible members to tune a stiffness characteristic of the actuator. The passive element can be a bi-stable element. The preferred embodiment actuator includes one or more layers of the elastomeric film integrated into the frame. The elastomeric film can be made of many elastomeric materials such as, for example, but not limited to, acrylic, silicone and latex.

    摘要翻译： 本发明涉及在磁性成像环境中使用的装置和系统，其包括具有至少两个电极的弹性介电膜的致动器装置和连接到致动器装置的框架。 该框架可以具有多个构造，包括例如至少两个构件，其可以是但不限于弯曲梁，杆，板或平行梁。 这些刚性构件可以联接到柔性构件，例如其中框架提供弹性恢复力的连杆。 框架优选地在位移范围上提供线性致动力特性。 线性致动力特性在位移范围内被定义为±20％，优选地为10％。 致动器还包括设置在柔性构件之间的无源元件，以调节致动器的刚度特性。 无源元件可以是双稳态元件。 优选实施例致动器包括集成到框架中的一层或多层弹性体膜。 弹性体膜可以由许多弹性体材料制成，例如但不限于丙烯酸，硅树脂和胶乳。

    Continuous magnetic resonance line-scan imaging in the presence of motion and varying magnetic field inhomogeneities within the field of view
    8.
    发明授权
    Continuous magnetic resonance line-scan imaging in the presence of motion and varying magnetic field inhomogeneities within the field of view 失效
    在存在运动和变化的磁场不均匀性的范围内的连续磁共振线扫描成像

    公开(公告)号：US06320378B1

    公开(公告)日：2001-11-20

    申请号：US09822646

    申请日：2001-03-30

    申请人： Stephan E. Maier ,  Ferenc A. Jolesz ,  Daniel F. Kacher

    发明人： Stephan E. Maier ,  Ferenc A. Jolesz ,  Daniel F. Kacher

    IPC分类号： G01V300

    CPC分类号： G01R33/54 ,  G01R33/4824 ,  G01R33/56509 ,  G01R33/56563

    摘要： Apparatus and method for generating and displaying undistorted images of a field of view containing undesirable motion and/or time varying magnetic field inhomogeneities, uses a time series of magnetic resonance (MR) image signals, corresponding to a time series of MR images, generated by a single-shot imaging technique without shot-to-shot phase encoding. Signals are stored and analyzed to identify missing and/or deteriorated images (including image portions, image lines or image line segments). Identified missing and/or deteriorated images are compensated for by replacement, repair or otherwise. MR image signals representative of a specified time series are selected. Then, selected signals of corresponding portions of the field of view are averaged. The invention may be used to present: a continuously updated time series of images; a time series of images with only a specified portions of the image updated in each display; or an entire time series of images re-created in any desired sequence.

    摘要翻译： 用于产生和显示包含不期望的运动和/或时变磁场不均匀性的视场的未失真图像的装置和方法使用对应于MR图像的时间序列的时间序列的磁共振（MR）图像信号，所述时间序列由MR图像信号产生的时间序列 单射成像技术，没有射击相位编码。 信号被存储和分析以识别缺失和/或退化的图像（包括图像部分，图像线或图像线段）。 通过更换，维修或其他方式补偿识别出的缺失和/或恶化的图像。 选择代表指定时间序列的MR图像信号。 然后，对视场的相应部分的选择信号进行平均。 本发明可以用于呈现：连续更新的时间序列的图像; 在每个显示中仅更新图像的指定部分的时间序列的图像; 或以任何期望的顺序重新创建的整个时间序列的图像。

    Virtual internal cavity inspection system
    9.
    发明授权
    Virtual internal cavity inspection system 失效
    虚拟内腔检查系统

    公开(公告)号：US5611025A

    公开(公告)日：1997-03-11

    申请号：US344445

    申请日：1994-11-23

    申请人： William E. Lorensen ,  Ferenc A. Jolesz ,  Ron Kikinis

    发明人： William E. Lorensen ,  Ferenc A. Jolesz ,  Ron Kikinis

    IPC分类号： A61B1/04 ,  A61B1/00 ,  A61B5/055 ,  A61B6/03 ,  G02B23/24 ,  G06T1/00 ,  G06T15/00 ,  G06T19/00 ,  G09B23/28 ,  A61B8/13

    CPC分类号： G09B23/285

    摘要： A virtual internal cavity inspection system non-invasively provides images of cavities of a subject from a viewpoint within the cavity. An acquisition unit acquires imaging information about internal structures of a subject. This imaging information is segmented into separate structures, and a 3D surface model is constructed. An operator views an image of the 3D model to select a goal viewpoint and a start viewpoint. A viewpoint path is created linking the start viewpoint and the goal viewpoint. Images are created with a viewpoints along the viewpoint path. A variety of additional visualization techniques aid the viewer's localization of the current image viewpoint, and its relation to the subject.

    摘要翻译： 虚拟内腔检查系统从空腔内的观点非侵入式地提供受试者的腔的图像。 采集单元获取关于对象的内部结构的成像信息。 该成像信息被分割为单独的结构，并且构建了3D表面模型。 操作者查看3D模型的图像以选择目标视点和起始视点。 创建连接开始视点和目标视点的视点路径。 沿着视点路径创建具有视点的图像。 各种其他可视化技术有助于观众对当前图像视点的定位及其与主体的关系。