公开(公告)号：US20190263786A1

公开(公告)日：2019-08-29

申请号：US16283451

申请日：2019-02-22

Applicant: GENENTECH, INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI ,  Zhiguo LIU ,  Wenfeng LIU ,  Ramsay BEVERIDGE ,  Jean-Philippe LECLERC ,  Alexandre LEMIRE ,  Liang ZHAO ,  Claudio STURINO

IPC: C07D403/12 ,  C07D233/96 ,  C07D401/12 ,  C07D401/14 ,  C07D263/52 ,  C07D305/06 ,  A61P17/04

Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180029984A1

公开(公告)日：2018-02-01

申请号：US15723805

申请日：2017-10-03

Applicant: GENENTECH, INC. ,  CURIS, INC.

Inventor： Janet L. GUNZNER-TOSTE ,  Daniel SUTHERLIN ,  Mark S. STANLEY ,  Liang BAO ,  Georgette M. CASTANEDO ,  Rebecca L. LALONDE ,  Shumei WANG ,  Mark E. REYNOLDS ,  Scott J. SAVAGE ,  Kimberly MALESKY ,  Michael S. DINA ,  Michael F.T. KOEHLER

IPC: C07D213/16 ,  C07D417/04 ,  C07F9/58 ,  C07D213/40 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D213/38 ,  C07D417/12

CPC classification number: C07D213/16 ,  C07D213/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07F9/58

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

公开(公告)号：US20210107895A1

公开(公告)日：2021-04-15

申请号：US17031492

申请日：2020-09-24

Applicant: GENENTECH, INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI

IPC: C07D401/14

Abstract: The invention provides a compounds and salts that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.

公开(公告)号：US20210070707A1

公开(公告)日：2021-03-11

申请号：US17081155

申请日：2020-10-27

Applicant: GENENTECH, INC. ,  CURIS, INC.

Inventor： Janet L. GUNZNER-TOSTE ,  Daniel SUTHERLIN ,  Mark S. STANLEY ,  Liang BAO ,  Georgette M. CASTANEDO ,  Rebecca L. LALONDE ,  Shumei WANG ,  Mark E. REYNOLDS ,  Scott J. SAVAGE ,  Kimberly MALESKY ,  Michael S. DINA ,  Michael F.T. KOEHLER

IPC: C07D213/16 ,  C07F9/58 ,  C07D213/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

公开(公告)号：US20180230079A1

公开(公告)日：2018-08-16

申请号：US15896970

申请日：2018-02-14

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Ivan William HEMEON ,  Brian SAFINA ,  Daniel SUTHERLIN

IPC: C07C62/38 ,  C07C62/34 ,  C07D211/22 ,  C07C323/61 ,  C07C317/44 ,  C07C313/04 ,  C07C229/48 ,  A61P17/04 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07C62/38 ,  A61P17/04 ,  A61P25/00 ,  A61P29/00 ,  C07C62/34 ,  C07C69/757 ,  C07C229/48 ,  C07C313/04 ,  C07C317/44 ,  C07C323/61 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/74 ,  C07D211/22

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20160152569A1

公开(公告)日：2016-06-02

申请号：US15015586

申请日：2016-02-04

Applicant: GENENTECH, INC. ,  CURIS, INC.

Inventor： Janet L. GUNZNER-TOSTE ,  Daniel SUTHERLIN ,  Mark S. STANLEY ,  Liang BAO ,  Georgette M. CASTANEDO ,  Rebecca L. LALONDE ,  Shumei WANG ,  Mark E. REYNOLDS ,  Scott J. SAVAGE ,  Kimberly MALESKY ,  Michael S. DINA ,  Michael F.T. KOEHLER

IPC: C07D213/16 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  C07D409/12

CPC classification number: C07D213/16 ,  C07D213/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07F9/58

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

公开(公告)号：US20150105550A1

公开(公告)日：2015-04-16

申请号：US14575018

申请日：2014-12-18

Applicant: GENENTECH, INC. ,  CURIS, INC.

Inventor： Janet L. GUNZNER ,  Daniel SUTHERLIN ,  Mark S. STANLEY ,  Liang BAO ,  Georgette M. CASTANEDO ,  Rebecca L. LALONDE ,  Shumei WANG ,  Mark E. REYNOLDS ,  Scott J. SAVAGE ,  Kimberly MALESKY ,  Michael S. DINA ,  Michael F.T. KOEHLER

IPC: C07D417/12 ,  C07D413/12 ,  C07D213/56 ,  C07D409/12 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D213/16 ,  C07D213/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07F9/58

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

公开(公告)号：US20210171516A1

公开(公告)日：2021-06-10

申请号：US17031348

申请日：2020-09-24

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Philippe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC: C07D417/12 ,  C07D417/14 ,  A61P17/04 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107

Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20210093618A1

公开(公告)日：2021-04-01

申请号：US16677487

申请日：2019-11-07

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Jean-Christophe ANDREZ ,  Paul Robert BICHLER ,  Chien-An CHEN ,  Sultan CHOWDHURY ,  Shannon Marie DECKER ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Ivan William HEMEON ,  Qi JIA ,  Jun LI ,  Zhiguo LIU ,  Daniel F. ORTWINE ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN ,  Tao SHENG ,  Shaoyi SUN ,  Andrew D. WHITE ,  Michael Scott WILSON ,  Alla Yurevna ZENOVA ,  Jiuxiang ZHU

IPC: A61K31/445 ,  C07D295/26 ,  A61K31/4015 ,  C07D211/22 ,  C07D233/68 ,  C07D305/08 ,  C07D205/12 ,  A61K31/4523 ,  C07D405/12 ,  C07D413/06 ,  C07D451/02 ,  C07D405/04 ,  C07D211/54 ,  C07D403/12 ,  C07D487/08 ,  C07D237/08 ,  C07D205/04 ,  C07D211/32 ,  A61K31/4412 ,  A61K31/415 ,  C07D401/04 ,  A61K31/337 ,  A61K31/495 ,  C07D211/60 ,  A61K31/4545 ,  C07D403/04 ,  C07D413/12 ,  C07D401/12 ,  C07D265/30 ,  C07D417/06 ,  C07D451/06 ,  C07D211/42 ,  A61K31/397 ,  C07F7/08 ,  C07D211/96 ,  C07D241/04 ,  C07D401/06 ,  C07D453/02 ,  C07D207/12 ,  C07D295/155

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20200087239A1

公开(公告)日：2020-03-19

申请号：US16685335

申请日：2019-11-15

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Ivan William HEMEON ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN

IPC: C07C62/38 ,  C07C69/757 ,  C07C62/34 ,  C07C229/48 ,  C07D211/22 ,  C07C317/44 ,  C07C323/61 ,  A61P25/00 ,  A61P29/00 ,  A61P17/04 ,  C07C313/04

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.