公开(公告)号：US11384341B2

公开(公告)日：2022-07-12

申请号：US17001015

申请日：2020-08-24

Applicant: Genomatica, Inc.

Inventor： Andreas Schirmer ,  Baolong Zhu ,  Emanuela Popova

IPC: C12N15/62 ,  C12N9/04 ,  C12N9/02 ,  C12N15/81 ,  C12N9/18

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US10787648B2

公开(公告)日：2020-09-29

申请号：US16063198

申请日：2016-12-13

Applicant: GENOMATICA, INC.

Inventor： Andreas Schirmer ,  Baolong Zhu ,  Emanuela Popova

IPC: C12N9/02 ,  C12N9/04 ,  C12N15/62 ,  C12N15/81 ,  C12N9/18

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20240117324A1

公开(公告)日：2024-04-11

申请号：US18355990

申请日：2023-07-20

Applicant: Genomatica, Inc.

Inventor： Mathew RUDE ,  Na Trinh ,  Andreas Schirmer ,  Jacob Gano

IPC: C12N9/02 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409

CPC classification number: C12N9/0008 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12Y102/0108

Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.

公开(公告)号：US20230037234A1

公开(公告)日：2023-02-02

申请号：US17780421

申请日：2020-11-25

Applicant: Genomatica, Inc.

Inventor： Jingyi Li ,  Pierre DeWals ,  Andreas Schirmer ,  Sankha Ghatak ,  David Ryan Georgianna

IPC: C12N15/52 ,  C12P7/42 ,  C12P19/32 ,  C12P7/06

Abstract: The invention relates to engineered microorganisms (e.g., E. coli) and associated improvements for increasing the production cannabinoids (e.g. CBGA) or precursors or derivatives thereof.

公开(公告)号：US12173329B2

公开(公告)日：2024-12-24

申请号：US18355990

申请日：2023-07-20

Applicant: Genomatica, Inc.

Inventor： Mathew Rude ,  Na Trinh ,  Andreas Schirmer ,  Jacob Gano

IPC: C12N9/02 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409

Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.

公开(公告)号：US20210230562A1

公开(公告)日：2021-07-29

申请号：US17001015

申请日：2020-08-24

Applicant: Genomatica, Inc.

Inventor： Andreas Schirmer ,  Baolong ZHU ,  Emanuela Popova

IPC: C12N9/04 ,  C12N15/62 ,  C12N9/02 ,  C12N15/81

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US12180515B2

公开(公告)日：2024-12-31

申请号：US17834681

申请日：2022-06-07

Applicant: Genomatica, Inc.

Inventor： Andreas Schirmer ,  Baolong Zhu ,  Emanuela Popova

IPC: C12N9/18 ,  C12N9/02 ,  C12N9/04 ,  C12N15/62 ,  C12N15/81

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US11130944B2

公开(公告)日：2021-09-28

申请号：US16272303

申请日：2019-02-11

Applicant: Genomatica, Inc.

Inventor： Mathew Rude ,  Na Trinh ,  Andreas Schirmer ,  Jacob Gano

IPC: C12N9/02 ,  C12P7/64 ,  C12P7/24 ,  C12P7/04

Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.