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公开(公告)号：US20140336423A1
公开(公告)日：2014-11-13
申请号：US14366517
申请日：2012-12-13
申请人： Codexis, Inc.
发明人： Fernando Valle , Svetlana Balatskaya , Yoram Barak , Louis Clark , Kristian Karlshoej , Patricia Choudhary , Catherine Cho , Kaman Chan , Jonathan Vroom
IPC分类号： C12P7/04 , C07C31/125 , C12N9/02
CPC分类号： C12P7/04 , A61K8/342 , A61K2800/10 , A61Q5/00 , A61Q19/00 , C07C31/125 , C12N9/0008 , C12Y102/01 , C12Y102/0105 , C12Y102/0108 , Y02P20/52
摘要： Recombinant bacterial microorganisms are provided which comprise heterologous fatty acyl reductases (“FAR”) polypeptides wherein said microorganisms have been engineered to produce increased amounts of saturated fatty alcohols and methods of making saturated fatty alcohols using the recombinant bacterial microorganisms.
摘要翻译： 提供了包含异源脂肪酰基还原酶（“FAR”）多肽的重组细菌微生物，其中所述微生物已被工程化以产生增加量的饱和脂肪醇和使用重组细菌微生物制备饱和脂肪醇的方法。
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公开(公告)号：US20130078686A1
公开(公告)日：2013-03-28
申请号：US13629492
申请日：2012-09-27
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005
摘要： The invention relates to acyl-CoA-independent methods of producing fatty alcohols in recombinant host cells engineered to express an alcohol-forming acyl-ACP reductase. The recombinant host cells may be photosynthetic microorganisms, such as cyanobacteria. Isolated nucleic acid molecules, vectors, and recombinant host cells expressing an alcohol-forming acyl-ACP reductase, and systems for producing fatty alcohols via an acyl-CoA-independent pathway, are also provided. Also provided are microorganisms engineered for the secretion of fatty acids and fatty acid derivatives, including fatty alcohols, and methods of producing fatty acid derivatives using such engineering microorganisms.
摘要翻译： 本发明涉及在工程化以表达形成醇的酰基-ACP还原酶的重组宿主细胞中产生脂肪醇的酰基辅酶A非依赖性方法。 重组宿主细胞可以是光合微生物，如蓝细菌。 还提供了分离的核酸分子，载体和表达成醇酰基ACP还原酶的重组宿主细胞，以及通过酰基辅酶A独立途径产生脂肪醇的体系。 还提供了用于分泌脂肪酸和脂肪酸衍生物（包括脂肪醇）的微生物以及使用这种工程微生物产生脂肪酸衍生物的方法。
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公开(公告)号：US20170240927A1
公开(公告)日：2017-08-24
申请号：US15284727
申请日：2016-10-04
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
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公开(公告)号：US08921090B2
公开(公告)日：2014-12-30
申请号：US13413426
申请日：2012-03-06
申请人： Erik Holtzapple , John H. Verruto
发明人： Erik Holtzapple , John H. Verruto
IPC分类号： C12N1/20 , C12P7/64 , C12P7/04 , C12N15/00 , C12N1/12 , C07H21/04 , C12N15/70 , C12N15/74 , C12N9/10 , C12N9/02 , C12N9/16
CPC分类号： C12P7/6409 , C07K14/21 , C07K14/28 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/70 , C12N15/74 , C12P5/02 , C12P7/04 , C12P7/6436 , C12Y102/0108 , C12Y203/0102 , C12Y203/01075 , C12Y203/01084 , C12Y301/0202 , C12Y401/01 , C12Y401/99005
摘要： The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol-forming acyl-ACP reductase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an acyl-ACP wax ester synthase and/or an alcohol-forming acyl-ACP reductase, recombinant host cells expressing an acyl-ACP wax ester synthase and optionally an alcohol-forming acyl-ACP reductase, and systems for producing a wax ester via an acyl-CoA-independent pathway, are also provided.
摘要翻译： 本发明涉及在工程化表达酰基-ACP蜡酯合酶的重组宿主细胞中产生蜡酯的酰基辅酶A独立方法和形成醇的酰基-ACP还原酶。 本发明的方法可以在光合微生物中发生，特别是在蓝细菌中。 分离的核苷酸分子和表达酰基-ACP蜡酯合酶和/或成醇酰基-ACP还原酶的载体，表达酰基-ACP蜡酯合成酶和任选的形成醇的酰基-ACP还原酶的重组宿主细胞，以及用于 还提供了通过酰基辅酶A独立途径产生蜡酯。
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公开(公告)号：US08846371B2
公开(公告)日：2014-09-30
申请号：US13625107
申请日：2012-09-24
申请人： LS9, Inc.
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
摘要翻译： 本文描述了用于生产醛，烷烃和烯烃的组合物和方法。 醛，烷烃和烯烃可用于生物燃料。
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公开(公告)号：US20140004580A1
公开(公告)日：2014-01-02
申请号：US13995912
申请日：2011-12-19
申请人： James Roberts , Fred Cross , Brett K. Kaiser
发明人： James Roberts , Fred Cross , Brett K. Kaiser
CPC分类号： C12P7/6436 , C12N9/0008 , C12N15/74 , C12N15/8242 , C12N15/8247 , C12P7/6409 , C12Y102/0108
摘要： This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that overexpress an acyl-acyl carrier protein reductase (acyl-ACP reductase). These microorganisms may optionally overexpress one or more fatty acid synthesis proteins such as ACP and ACCase, and/or one or more polypeptides associated with glycogen breakdown. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism. The modified photosynthetic microorganisms provided herein are capable of producing increased amounts of lipids such as fatty acids or wax esters and/or synthesizing triglycerides.
摘要翻译： 本公开描述了过表达酰基酰基载体蛋白还原酶（酰基-ACP还原酶）的转基因修饰的光合微生物，例如蓝细菌。 这些微生物可以任选地过表达一种或多种脂肪酸合成蛋白，例如ACP和ACCase，和/或与糖原分解有关的一种或多种多肽。 还包括光合微生物，其包含糖原生物合成或储存途径中的突变或缺失，与野生型光合微生物相比，其在降低的氮条件下积累减少量的糖原。 本文提供的修饰的光合微生物能够产生增加量的脂质，例如脂肪酸或蜡酯和/或合成甘油三酯。
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7.发明申请公开(公告)号：US20120282663A1
公开(公告)日：2012-11-08
申请号：US13552522
申请日：2012-07-18
申请人： Andreas Schirmer , Mathew Rude , Shane Brubaker
发明人： Andreas Schirmer , Mathew Rude , Shane Brubaker
CPC分类号： C12P7/64 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/0108 , C12Y401/99005 , Y02E50/13 , Y02P20/52 , Y02T50/678
摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.
摘要翻译： 本文描述了用于生产烃类如醛，烷烃和烯烃的组合物和方法。 某些碳氢化合物可用于生物燃料。
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公开(公告)号：US20240117324A1
公开(公告)日：2024-04-11
申请号：US18355990
申请日：2023-07-20
申请人： Genomatica, Inc.
发明人： Mathew RUDE , Na Trinh , Andreas Schirmer , Jacob Gano
IPC分类号： C12N9/02 , C12P7/04 , C12P7/24 , C12P7/6409
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y102/0108
摘要： The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
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公开(公告)号：US09873865B2
公开(公告)日：2018-01-23
申请号：US15621430
申请日：2017-06-13
发明人： Mathew Rude , Na Trinh , Andreas Schirmer , Jacob Gano
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y102/0108
摘要： The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
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公开(公告)号：US20170342388A1
公开(公告)日：2017-11-30
申请号：US15621430
申请日：2017-06-13
发明人： Mathew Rude , Na TRINH , Andreas Schirmer , Jacob GANO
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/24 , C12P7/6409 , C12Y102/0108
摘要： The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
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