公开(公告)号：US20240229086A1

公开(公告)日：2024-07-11

申请号：US18284349

申请日：2022-03-22

Applicant: GENOMATICA, INC.

Inventor： Andreas W. SCHIRMER ,  Erin Frances PERRY ,  Alma Itzel RAMOS-SOLIS ,  Angelica ZABALA-BAUTISTA

IPC: C12P7/6409 ,  C12N1/20 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88

CPC classification number: C12P7/6409 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/88 ,  C12Y114/19002 ,  C12Y203/01084 ,  C12Y207/08007 ,  C12Y301/02014 ,  C12Y402/01059

Abstract: Recombinant proteobacteria, including γ-proteobacteria, comprising a heterologous acyl-ACP desaturase and a heterologous acyl-ACP thioesterase, wherein the native dual 3-hydroxy acyl-ACP dehydratase/isomerase is deleted are provided herein. The recombinant proteobacteria produce non-native monounsaturated free fatty acids or derivatives thereof. Methods of producing non-native monounsaturated free fatty acids or derivatives thereof are also provided, in addition to cell cultures and fatty acid compositions produced by the recombinant proteobacteria. The recombinant proteobacteria may be used to produce insect pheromones or precursors thereof, and fragrances or precursors thereof.

公开(公告)号：US20210189439A1

公开(公告)日：2021-06-24

申请号：US17053190

申请日：2019-05-03

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Risha Lindig BOND ,  Erin Frances PERRY

IPC: C12P7/18 ,  C12N15/52

Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides novel multifunctional fatty acid derivative molecules such as e.g., fatty triols, fatty tetrols, dihydroxy fatty acids, etc. The disclosure further provides derivatives of the disclosed multifunctional molecules which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc. The disclosure further provides biochemical pathways, recombinant microorganisms and methods for the biological production of various multifunctional fatty acid derivatives.

公开(公告)号：US20210189373A1

公开(公告)日：2021-06-24

申请号：US17271439

申请日：2019-08-28

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Katherine Ann MURPHY ,  Erin Frances PERRY

IPC: C12N9/88 ,  C12N9/16 ,  C12N9/10 ,  C12N9/02 ,  C12N9/04 ,  C12P7/64

Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase/isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.