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公开(公告)号：US20240229086A1
公开(公告)日：2024-07-11
申请号：US18284349
申请日：2022-03-22
Applicant: GENOMATICA, INC.
Inventor： Andreas W. SCHIRMER , Erin Frances PERRY , Alma Itzel RAMOS-SOLIS , Angelica ZABALA-BAUTISTA
CPC classification number: C12P7/6409 , C12N1/20 , C12N9/0006 , C12N9/0008 , C12N9/0071 , C12N9/1029 , C12N9/1288 , C12N9/16 , C12N9/88 , C12Y114/19002 , C12Y203/01084 , C12Y207/08007 , C12Y301/02014 , C12Y402/01059
Abstract: Recombinant proteobacteria, including γ-proteobacteria, comprising a heterologous acyl-ACP desaturase and a heterologous acyl-ACP thioesterase, wherein the native dual 3-hydroxy acyl-ACP dehydratase/isomerase is deleted are provided herein. The recombinant proteobacteria produce non-native monounsaturated free fatty acids or derivatives thereof. Methods of producing non-native monounsaturated free fatty acids or derivatives thereof are also provided, in addition to cell cultures and fatty acid compositions produced by the recombinant proteobacteria. The recombinant proteobacteria may be used to produce insect pheromones or precursors thereof, and fragrances or precursors thereof.
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公开(公告)号：US20210071207A1
公开(公告)日：2021-03-11
申请号：US16889211
申请日：2020-06-01
Applicant: Genomatica, Inc.
Inventor： Andreas W. Schirmer , Noah HELMAN , Haibo Wang , Zhihao Hu , Vikranth Arlagadda , Alma Itzel RAMOS-SOLIS , Elizabeth Clarke
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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Patent Agency Ranking
公开(公告)号：US20250101471A1
公开(公告)日：2025-03-27
申请号：US18800482
申请日：2024-08-12
Applicant: Genomatica, Inc.
Inventor： Andreas W. SCHIRMER , Noah HELMAN , Haibo WANG , Zhihao HU , Vikranth ARLAGADDA , Alma Itzel RAMOS-SOLIS , Elizabeth J. CLARKE
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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公开(公告)号：US20250059524A1
公开(公告)日：2025-02-20
申请号：US18937302
申请日：2024-11-05
Applicant: Genomatica, Inc.
Inventor： Angelica Zabala BAUTISTA , Min Sun PARK , Alma Itzel RAMOS-SOLIS , Bernardo Moura TORRES DA COSTA , Behnaz BEHROUZIAN , Donald E. TRIMBUR , Emanuela POPOVA , Qijun HU , Stephen Bralley DEL CARDAYRE
IPC: C12N9/16 , C12P7/6409 , C12P7/6436
Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.
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公开(公告)号：US20220267813A1
公开(公告)日：2022-08-25
申请号：US17732799
申请日：2022-04-29
Applicant: Genomatica, Inc.
Inventor： Andreas W. SCHIRMER , Noah HELMAN , Haibo WANG , Zhihao HU , Vikranth ARLAGADDA , Alma Itzel RAMOS-SOLIS , Elizabeth CLARKE
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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公开(公告)号：US20220243185A1
公开(公告)日：2022-08-04
申请号：US17715587
申请日：2022-04-07
Applicant: Genomatica, Inc.
Inventor： Angelica Zabala BAUTISTA , Min Sun PARK , Alma Itzel RAMOS-SOLIS , Bernardo Moura TORRES DA COSTA , Behnaz BEHROUZIAN , Donald E. TRIMBUR , Emanuela POPOVA , Qijun HU , Stephen Bralley DEL CARDAYRE
IPC: C12N9/16 , C12P7/6409
Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.
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公开(公告)号：US20210207111A1
公开(公告)日：2021-07-08
申请号：US16500188
申请日：2018-04-03
Applicant: Genomatica, Inc.
Inventor： Angelica Zabala BAUTISTA , Min Sun PARK , Alma Itzel RAMOS-SOLIS , Bernardo Moura TORRES DA COSTA , Behnaz BEHROUZIAN , Donald E. TRIMBUR , Emanuela POPOVA , Qijun HU , Stephen Bralley DEL CARDAYRE
Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.
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