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公开(公告)号：US20210371836A1
公开(公告)日：2021-12-02
申请号：US17204449
申请日：2021-03-17
Applicant: Genomatica, Inc.
Inventor： Louis HOM , Na TRINH , Murtaza ALIBHAI , Zhihao HU , Eli GROBAN , Vikranth ARLAGADDA , Elizabeth CLARKE
Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
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Patent Agency Ranking
公开(公告)号：US20210324430A1
公开(公告)日：2021-10-21
申请号：US17164025
申请日：2021-02-01
Applicant: Genomatica, Inc.
Inventor： Zhihao HU , Vikranth ARLAGADDA
Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
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公开(公告)号：US20250101471A1
公开(公告)日：2025-03-27
申请号：US18800482
申请日：2024-08-12
Applicant: Genomatica, Inc.
Inventor： Andreas W. SCHIRMER , Noah HELMAN , Haibo WANG , Zhihao HU , Vikranth ARLAGADDA , Alma Itzel RAMOS-SOLIS , Elizabeth J. CLARKE
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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公开(公告)号：US20250092355A1
公开(公告)日：2025-03-20
申请号：US18816019
申请日：2024-08-27
Applicant: Genomatica, Inc.
Inventor： Derek L. GREENFIELD , Louis G. HOM , Fernando A. SANCHEZ-RIERA , Zhihao HU , Vikranth ARLAGADDA , Eli S. GROBAN , Scott A. FRYKMAN
IPC: C12N1/20 , C07C31/125 , C07C33/02 , C07C53/126 , C07K14/195 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C12P7/6409
Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
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公开(公告)号：US20220267813A1
公开(公告)日：2022-08-25
申请号：US17732799
申请日：2022-04-29
Applicant: Genomatica, Inc.
Inventor： Andreas W. SCHIRMER , Noah HELMAN , Haibo WANG , Zhihao HU , Vikranth ARLAGADDA , Alma Itzel RAMOS-SOLIS , Elizabeth CLARKE
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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公开(公告)号：US20210371889A1
公开(公告)日：2021-12-02
申请号：US17350690
申请日：2021-06-17
Applicant: Genomatica, Inc.
Inventor： Derek L. GREENFIELD , Louis G. HOM , Fernando A. SANCHEZ-RIERA , Zhihao HU , Vikranth ARLAGADDA , Eli S. GROBAN , Scott A. FRYKMAN
IPC: C12P7/64 , C07K14/245 , C07K14/195 , C07C31/125 , C07C33/02 , C07C53/126
Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
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