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公开(公告)号:US07204990B1
公开(公告)日:2007-04-17
申请号:US09724935
申请日:2000-11-28
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/245 , A61K39/12 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
摘要翻译: 提供了一种减毒巨细胞病毒的方法,其包括功能性地破坏托莱多基因组区域的开放阅读框或其同源物并制备嵌合CMV病毒基因组。
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公开(公告)号:US07611718B1
公开(公告)日:2009-11-03
申请号:US11614035
申请日:2006-12-20
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/12 , A61K39/245 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
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公开(公告)号:US07550149B2
公开(公告)日:2009-06-23
申请号:US11614141
申请日:2006-12-21
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/12 , A61K39/245 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
摘要翻译: 提供了一种减毒巨细胞病毒的方法,其包括功能性地破坏托莱多基因组区域的开放阅读框或其同源物并制备嵌合CMV病毒基因组。
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公开(公告)号:US07537770B2
公开(公告)日:2009-05-26
申请号:US11613501
申请日:2006-12-20
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/12 , A61K39/245 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
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公开(公告)号:US20080019945A1
公开(公告)日:2008-01-24
申请号:US11613501
申请日:2006-12-20
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
摘要翻译: 提供了一种减毒巨细胞病毒的方法,其包括功能性地破坏托莱多基因组区域的开放阅读框或其同源物并制备嵌合CMV病毒基因组。
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公开(公告)号:US5229111A
公开(公告)日:1993-07-20
申请号:US648098
申请日:1991-01-31
IPC分类号: A61K39/125 , C12N7/00 , C12N7/04
CPC分类号: C12N7/00 , A61K39/12 , A61K39/125 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , C12N2770/32234 , C12N2770/32261
摘要: A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.
摘要翻译: 公开了一种用于在非鼠哺乳动物中抑制小RNA病毒病的方法。 向哺乳动物施用含有具有缩短的聚(C)道的活的,重组的,减毒的小核糖核酸病毒的疫苗。 优选地,疫苗中的小核糖核酸病毒与致病微小RNA病毒具有相同的属性,并且具有缩短的聚(C)道。 疫苗的施用导致在体内形成对于致病微小RNA病毒有效的抗体。 在本发明的一个实施方案中,含有缩短的聚(C)链的孟诺病毒的疫苗可用作猪和猴两者的疫苗。
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公开(公告)号:US4937190A
公开(公告)日:1990-06-26
申请号:US109132
申请日:1987-10-15
摘要: Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer acts at the RNA level (as opposed to the DNA level) to enhance production of proteins in cell free media. Proteinaceous material which is produced will not have attached to it any undesired material from the enhancer sequence. The invention is especially useful to enable efficient production of selected viral proteins of picornoviruses.
摘要翻译: 在该专利中公开的是包含衍生自心脏病毒的5'非编码区的翻译增强子区的DNA序列,RNA序列,载体和宿主。 增强子作用于RNA水平(与DNA水平相反)以增强无细胞培养基中蛋白质的产生。 产生的蛋白质材料将不会与增强子序列中的任何不需要的物质连接。 本发明特别有助于有效地生产选择性的细小病毒病毒蛋白质。
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