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1.发明申请COMPOSITIONS, METHODS AND USES FOR EXPRESSION OF ENTEROBACTERIUM-ASSOCIATED PEPTIDES 审中-公开组合物，用于表达肠壁菌相关肽的方法和用途公开(公告)号：US20150343046A1
公开(公告)日：2015-12-03
申请号：US14679944
申请日：2015-04-06
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达肠细菌相关肽的方法，组合物和用途。 在一些实施方案中，肠细菌相关肽包括但不限于瘟疫相关肽。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于表达肠细菌相关肽的减毒或修饰的痘苗病毒载体。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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公开(公告)号：US20140302091A1
公开(公告)日：2014-10-09
申请号：US13300217
申请日：2011-11-18
CPC分类号： A61K39/12 , A61K47/26 , A61K47/36 , A61K47/42 , A61K2039/5254 , A61K2039/55555 , A61K2039/70 , C08G2650/58 , C08L71/02 , C08L2203/02 , C12N7/00 , C12N2710/10051 , C12N2710/10061 , C12N2710/24151 , C12N2710/24161 , C12N2760/16051 , C12N2760/16061 , C12N2760/18411 , C12N2770/24134 , C12N2770/24151 , C12N2770/24161 , C12N2770/36151 , C12N2770/36161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation of the live, attenuated virus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated virus composition may include at least one carbohydrate, at least one protein and at least one high molecular weight surfactants for reducing inactivation and/or degradation of the live, attenuated virus.
摘要翻译： 本文的实施方案涉及活病毒的组合物和方法。 在某些实施方案中，活的减毒病毒组合物包括但不限于一种或多种活的，减毒的病毒和组合物，以减少活的，减毒的病毒的失活和/或降解。 在其它实施方案中，活的减毒病毒组合物可以是疫苗组合物。 在其它组合物中，活的减毒病毒组合物可包括至少一种碳水化合物，至少一种蛋白质和至少一种用于减少活的，减毒病毒的失活和/或降解的高分子量表面活性剂。
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公开(公告)号：US20130209513A1
公开(公告)日：2013-08-15
申请号：US13555026
申请日：2012-07-20
IPC分类号： C12N15/863
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US20130136767A1
公开(公告)日：2013-05-30
申请号：US13510601
申请日：2010-11-22
IPC分类号： C12N15/863 , A61K39/145 , A61K39/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24134 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US20130034583A1
公开(公告)日：2013-02-07
申请号：US13511652
申请日：2010-11-24
IPC分类号： C12N15/63 , A61P37/04 , A61K39/275
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US5229111A
公开(公告)日：1993-07-20
申请号：US648098
申请日：1991-01-31
IPC分类号： A61K39/125 , C12N7/00 , C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/125 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , C12N2770/32234 , C12N2770/32261
摘要： A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.
摘要翻译： 公开了一种用于在非鼠哺乳动物中抑制小RNA病毒病的方法。 向哺乳动物施用含有具有缩短的聚（C）道的活的，重组的，减毒的小核糖核酸病毒的疫苗。 优选地，疫苗中的小核糖核酸病毒与致病微小RNA病毒具有相同的属性，并且具有缩短的聚（C）道。 疫苗的施用导致在体内形成对于致病微小RNA病毒有效的抗体。 在本发明的一个实施方案中，含有缩短的聚（C）链的孟诺病毒的疫苗可用作猪和猴两者的疫苗。
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7.发明授权Compositions, methods and uses for expression of enterobacterium-associated peptides 有权用于表达肠杆菌相关肽的组合物，方法和用途公开(公告)号：US09028809B2
公开(公告)日：2015-05-12
申请号：US13511652
申请日：2010-11-24
IPC分类号： A01N63/00 , A61K39/275 , A61K39/00 , A61K39/02
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达肠细菌相关肽的方法，组合物和用途。 在一些实施方案中，肠细菌相关肽包括但不限于瘟疫相关肽。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于表达肠细菌相关肽的减毒或修饰的痘苗病毒载体。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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8.发明授权公开(公告)号：US09011874B2
公开(公告)日：2015-04-21
申请号：US13510601
申请日：2010-11-22
IPC分类号： A61K49/00 , A61K39/38 , A61K39/295 , A61K39/145 , A61K39/245 , C12Q1/70 , C12N15/863 , A61K39/12 , A61K39/00 , C07K14/005
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24134 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达痘病毒构建体的方法，组合物和用途。 在一些实施方案中，构建体可以含有流感病毒基因区段。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于痘病毒疫苗组合物。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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9.发明授权Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains 有权针对流感病毒亚型或株系的疫苗结构中痘病毒元件的组成，方法和用途公开(公告)号：US09005632B2
公开(公告)日：2015-04-14
申请号：US13555026
申请日：2012-07-20
IPC分类号： A61K49/00 , A61K39/38 , A61K39/295 , A61K39/145 , A61K39/245 , C12Q1/70 , C12N15/863 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达痘病毒构建体的方法，组合物和用途。 在一些实施方案中，构建体可以含有流感病毒基因区段。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于具有两个或更多个流感基因片段的痘病毒疫苗组合物。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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公开(公告)号：US08968996B2
公开(公告)日：2015-03-03
申请号：US13492884
申请日：2012-06-10
IPC分类号： C12Q1/70 , A61K39/295 , A61K39/12 , A61K45/06 , A61K39/00
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject against all dengue virus serotypes. In some embodiments, multiple vaccine compositions may be administered to a subject in different anatomical locations in order to induce a rapid response to all dengue virus serotypes. In certain embodiments, administration of two or more vaccine compositions to a subject against all dengue virus serotypes may include two or more routes of administration.
摘要翻译： 本发明的实施方案报道了针对所有登革热病毒血清型疫苗接种受试者的组合物和方法。 在一些实施方案中，可以将多种疫苗组合物施用于不同解剖位置的受试者，以便诱导对所有登革热病毒血清型的快速反应。 在某些实施方案中，将两种或更多种疫苗组合物施用于所有登革热病毒血清型的受试者可包括两种或更多种施用途径。
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