公开(公告)号：US09623129B2

公开(公告)日：2017-04-18

申请号：US11534847

申请日：2006-09-25

申请人： Gilbert R. Gonzales ,  Dale DeVore ,  Suresh Srivastava

发明人： Gilbert R. Gonzales ,  Dale DeVore ,  Suresh Srivastava

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/10

CPC分类号： A61K51/1018 ,  A61K51/1093 ,  A61K2121/00

摘要： Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.

公开(公告)号：US20070071676A1

公开(公告)日：2007-03-29

申请号：US11534847

申请日：2006-09-25

申请人： Gilbert Gonzales ,  Dale DeVore ,  Suresh Srivastava

发明人： Gilbert Gonzales ,  Dale DeVore ,  Suresh Srivastava

IPC分类号： A61K51/00

CPC分类号： A61K51/1018 ,  A61K51/1093 ,  A61K2121/00

摘要： Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.

摘要翻译： 用于治疗和成像患者易损斑块和其他炎性病症的组合物和方法依赖于将转化的电子发射源和其它放射性核素递送到脉管系统或其他体腔内暴露胶原的区域。 转换电子发射源或其他放射性核素与胶原结合物质偶联，并施用于脉管系统或其他体腔，以允许用于成像和/或治疗目的的结合。

公开(公告)号：US20050231682A1

公开(公告)日：2005-10-20

申请号：US11146153

申请日：2005-06-07

申请人： Bruce DeWoolfson ,  Dale DeVore

发明人： Bruce DeWoolfson ,  Dale DeVore

IPC分类号： A61F2/14 ,  A61F9/00 ,  A61K38/17 ,  A61K38/39 ,  G02C7/04

CPC分类号： A61K38/1709 ,  A61K38/39 ,  G02C7/047

摘要： Two types of compositions having an eye-drop delivery system are used during or after an orthokeratology procedure to prevent or retard relaxation of corneal tissue back to the original anterior curvature of the cornea. Each composition functions independently from the others and is a different approach of preparing a stabilizing agent. The first composition is directed to a biologically compatible composition comprising fibril associated collagens with interrupted triple helices (FACITs) and/or small leucine-rich repeat proteoglycans (SLRPs). The fibril associated collagen family includes various types of collagens, such as type VI, type XX, type XII, and type XIV. The small leucine-rich repeat proteoglycans family includes decorin, keratocan, biglycan, epiphycan, lumican, mimecan, and fibromodulin. The second composition includes the enzyme found as a normal component of tissues, plasma, or epidermis, such as transglutaminase.

公开(公告)号：US20070178170A1

公开(公告)日：2007-08-02

申请号：US11683268

申请日：2007-03-07

申请人： Dale DeVore ,  Frank Long ,  Micah Osborne ,  Randall Adams ,  Marshall Franklin

发明人： Dale DeVore ,  Frank Long ,  Micah Osborne ,  Randall Adams ,  Marshall Franklin

IPC分类号： A61K35/54

CPC分类号： A61K35/57

摘要： The present invention relates to anti-inflammatory activity of eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to eggshell membrane compositions exhibiting anti-inflammatory activity as measured by effects on down-regulating pro-inflammatory plasma antigens in mammals that had orally ingested such compositions. This information supports the potential benefits from administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations to reduce pain and inflammation associated with arthritis and other inflammatory conditions.

摘要翻译： 本发明涉及蛋壳膜，加工蛋壳膜制剂和蛋壳膜分离物的抗炎活性。 本发明涉及通过对口服摄取这种组合物的哺乳动物中的下调促炎血浆抗原的作用测量显示抗炎活性的蛋壳膜组合物。 该信息支持从蛋壳膜，加工的蛋壳膜，蛋壳膜分离物和组合中发现的天然存在的材料的管理的潜在益处，以减少与关节炎和其他炎性病症相关的疼痛和炎症。

公开(公告)号：US6161544A

公开(公告)日：2000-12-19

申请号：US14955

申请日：1998-01-28

申请人： Dale DeVore ,  Rory H. Oefinger

发明人： Dale DeVore ,  Rory H. Oefinger

IPC分类号： A61F9/007 ,  A61F9/00 ,  A61F9/009 ,  A61F9/01 ,  A61F9/013 ,  A61K31/185 ,  A61K45/00 ,  A61P27/02 ,  G02C7/04 ,  A61B19/00

CPC分类号： A61F9/008 ,  A61F9/009 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61F2009/00882 ,  G02C7/047

摘要： An accelerated method of orthokeratology includes the steps of softening of the cornea with a softening agent, applying a mold to reshape the cornea to a desired anterior curvature, and rapidly restabilizing or "fixing" the corneal tissues so that the cornea retains its new configuration. A chemical softening agent, such as glutaric anhydride is applied to the cornea to soften the cornea, after which a specially designed mold of predetermined curvature and configuration is applied to the cornea. Slight downward pressure is applied to the mold for a predetermined period of time to re-shape the cornea. The mold is maintained in position while a stabilizing agent, such as a UV light source, is positioned above the mold. The stabilizing agent, i.e. UV light, is applied to the cornea for a predetermined time, wherein the stabilizing agent immediately restabilizes the corneal tissue so that the cornea immediately retains its shape upon removal of the mold. The stabilization process can also be used for patients having already undergone traditional orthokeratology to eliminate the need to continue wearing a retainer to maintain the shape of the cornea.

摘要翻译： 一种加速矫形术的方法包括用软化剂软化角膜的步骤，应用模具将角膜重新形成期望的前曲率，并且快速地恢复或“固定”角膜组织，使得角膜保持其新的构型。 向角膜施加化学软化剂如戊二酸酐以软化角膜，之后将具有预定曲率和构型的专门设计的模具应用于角膜。 向模具施加稍微向下的压力一段预定的时间以重新形成角膜。 模具保持在适当的位置，而诸如UV光源的稳定剂位于模具上方。 将稳定剂即UV光施加到角膜预定时间，其中稳定剂立即使角膜组织恢复稳定，使得角膜在移除模具时立即保持其形状。 稳定过程也可以用于已经经历了传统角膜曲率学的患者，以消除继续佩戴保持器以维持角膜的形状的需要。

公开(公告)号：US20110060267A1

公开(公告)日：2011-03-10

申请号：US12922424

申请日：2009-03-10

申请人： Bruce DeWoolfson ,  Dale DeVore

发明人： Bruce DeWoolfson ,  Dale DeVore

IPC分类号： A61F9/00

CPC分类号： A61K33/26 ,  A61K33/02 ,  A61K33/04 ,  A61K33/40 ,  A61K41/00 ,  A61K2300/00

摘要： Methods of strengthening the biomechanical properties of the cornea by exposing the cornea to ultraviolet light in the presence of a photoinitiator are described. These methods can be used to treat keratoconus. They can also be used to treat ectasia following a surgical procedure, or to strengthen the cornea prior to a surgical procedure.

摘要翻译： 描述了通过在光引发剂的存在下将角膜暴露于紫外光来增强角膜的生物力学性质的方法。 这些方法可用于治疗圆锥角膜。 它们也可用于治疗外科手术后的扩张，或在外科手术之前加强角膜。

公开(公告)号：US20090105127A1

公开(公告)日：2009-04-23

申请号：US12285683

申请日：2008-10-10

申请人： Vance Thompson ,  Bruce DeWoolfson ,  Dale DeVore

发明人： Vance Thompson ,  Bruce DeWoolfson ,  Dale DeVore

IPC分类号： A61K38/16

CPC分类号： A61K38/39 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/45 ,  C07K14/4725

摘要： Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.

摘要翻译： 公开了在角膜中稳定胶原原纤维的方法。 可以通过用交联胶原原纤维的蛋白质（例如核心蛋白聚糖）处理角膜来实现稳定化。 稳定方法包括在外科手术之前，期间或之后治疗角膜，治疗角膜炎，以及治疗圆锥角膜。

公开(公告)号：US20160000885A1

公开(公告)日：2016-01-07

申请号：US14807117

申请日：2015-07-23

申请人： Vance Thompson ,  Bruce DeWoolfson ,  Dale DeVore

发明人： Vance Thompson ,  Bruce DeWoolfson ,  Dale DeVore

IPC分类号： A61K38/39 ,  A61K9/00

CPC分类号： A61K38/39 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/45 ,  C07K14/4725

摘要： Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.

摘要翻译： 公开了在角膜中稳定胶原原纤维的方法。 可以通过用交联胶原原纤维的蛋白质（例如核心蛋白聚糖）处理角膜来实现稳定化。 稳定方法包括在外科手术之前，期间或之后治疗角膜，治疗角膜炎，以及治疗圆锥角膜。

公开(公告)号：US20080063677A1

公开(公告)日：2008-03-13

申请号：US11943169

申请日：2007-11-20

申请人： Frank Long ,  Randall Adams ,  Dale DeVore ,  Marshall Franklin

发明人： Frank Long ,  Randall Adams ,  Dale DeVore ,  Marshall Franklin

IPC分类号： A61K8/98 ,  A61K35/12 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q19/00 ,  A61K8/06

CPC分类号： A61Q19/007 ,  A61K8/982 ,  A61K35/57 ,  A61Q5/00 ,  A61Q19/08

摘要： The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membranes processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.

摘要翻译： 本发明涉及用于蛋壳膜，加工的蛋壳膜制剂和蛋壳膜分离物的治疗，化妆品和营养保健应用。 本发明涉及治疗哺乳动物，其将通过向哺乳动物施用含有蛋壳膜的蛋壳膜，蛋壳膜分离物的组合物来施用蛋壳膜，加工的蛋壳膜，蛋壳膜分离物及其组合中发现的天然存在的材料 单独或与其它活性成分组合。

公开(公告)号：US20080014282A1

公开(公告)日：2008-01-17

申请号：US11861438

申请日：2007-09-26

申请人： Frank Long ,  Randall Adams ,  Dale DeVore ,  Marshall Franklin

发明人： Frank Long ,  Randall Adams ,  Dale DeVore ,  Marshall Franklin

IPC分类号： A61K31/728 ,  A61K31/726 ,  A61K31/737 ,  A61K35/12 ,  A61K35/32 ,  A61K35/56 ,  A61K35/60 ,  A61P3/02

CPC分类号： A61Q5/00 ,  A61K8/982

摘要： The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.

摘要翻译： 本发明涉及用于蛋壳膜，加工的蛋壳膜制剂和蛋壳膜分离物的治疗，化妆品和营养保健应用。 本发明涉及治疗哺乳动物，其将通过向哺乳动物施用包含蛋壳膜，加工的蛋壳膜，蛋壳膜的组合物，从而对由蛋壳膜，加工的蛋壳膜，蛋壳膜分离物及其组合中发现的天然存在的材料施用而受益。 分离物及其组合，单独或与其它活性成分组合。