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1.发明申请公开(公告)号：US20180179191A1
公开(公告)日：2018-06-28
申请号：US15809296
申请日：2017-11-10
Applicant: Gilead Sciences, Inc.
Inventor： Jinyu Shen , Mustapha St. Jules , David Sperandio , Sankar Mohan
IPC: C07D403/14 , C07D235/08 , C07D213/30 , C07D261/08 , C07B37/04 , C07B37/10
CPC classification number: C07D403/14 , C07B37/04 , C07B37/10 , C07D213/30 , C07D235/08 , C07D261/08 , C07D413/04 , C07D413/14
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: or a salt or co-crystal thereof, that modulates the activity of bromodomain-containing proteins. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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Patent Agency Ranking
公开(公告)号：US12012431B2
公开(公告)日：2024-06-18
申请号：US18108480
申请日：2023-02-10
Applicant: Gilead Sciences, Inc.
Inventor： Sankar Mohan
Abstract: The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US11613553B2
公开(公告)日：2023-03-28
申请号：US17198829
申请日：2021-03-11
Applicant: Gilead Sciences, Inc.
Inventor： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A. J. Uhlig , Tiago Vieira , Todd A. Wenderski
Abstract: The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US20240409575A1
公开(公告)日：2024-12-12
申请号：US18655876
申请日：2024-05-06
Applicant: Gilead Sciences, Inc.
Inventor： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A.J. Uhlig , Tiago Vieira , Todd A. Wenderski
Abstract: The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US20230295214A1
公开(公告)日：2023-09-21
申请号：US18108480
申请日：2023-02-10
Applicant: Gilead Sciences, Inc.
Inventor： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A.J. Uhlig , Tiago Vieira , Todd A. Wenderski
Abstract: The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US20210309689A1
公开(公告)日：2021-10-07
申请号：US17198829
申请日：2021-03-11
Applicant: Gilead Sciences, Inc.
Inventor： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A.J. Uhlig , Tiago Vieira , Todd A. Wenderski
Abstract: The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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