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公开(公告)号:US10858376B2
公开(公告)日:2020-12-08
申请号:US16695253
申请日:2019-11-26
发明人: Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US10308668B2
公开(公告)日:2019-06-04
申请号:US15792251
申请日:2017-10-24
发明人: Michael Richard Kevin Alley , Vincent Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US20210053999A1
公开(公告)日:2021-02-25
申请号:US17089058
申请日:2020-11-04
发明人: Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US20200095266A1
公开(公告)日:2020-03-26
申请号:US16695253
申请日:2019-11-26
发明人: Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US10526352B2
公开(公告)日:2020-01-07
申请号:US16385547
申请日:2019-04-16
发明人: Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US20190241586A1
公开(公告)日:2019-08-08
申请号:US16385547
申请日:2019-04-16
发明人: Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号:US20140221631A1
公开(公告)日:2014-08-07
申请号:US14201459
申请日:2014-03-07
发明人: Stephen J. BAKER , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20170355719A1
公开(公告)日:2017-12-14
申请号:US15685846
申请日:2017-08-24
发明人: Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号: C07F5/02
CPC分类号: C07F5/025
摘要: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
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公开(公告)号:US09751898B2
公开(公告)日:2017-09-05
申请号:US14221637
申请日:2014-03-21
发明人: Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号: C07F5/02
CPC分类号: C07F5/025
摘要: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
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公开(公告)号:US20150119364A1
公开(公告)日:2015-04-30
申请号:US14537771
申请日:2014-11-10
发明人: Stephen J. BAKER , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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