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公开(公告)号:US20150274923A1
公开(公告)日:2015-10-01
申请号:US14632730
申请日:2015-02-26
Inventor: Jui-Yang Lai , Kao-Yuan Chang , Zih-Han Hong , Po-Cheng Lin , Ming-Hsi Chuang
CPC classification number: C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
Abstract translation: 提供一种制造中空颗粒的方法。 该方法包括以下步骤:(a)提供中空颗粒; (b)将中空颗粒浸泡在胺溶液中以在中空颗粒的表面上形成胺基; (c)加入多肽,并且多肽与中空颗粒表面上的胺基连接; 和(d)添加目标分子,并且靶分子与尚未结合的胺基结合。
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公开(公告)号:US20150238534A1
公开(公告)日:2015-08-27
申请号:US14632760
申请日:2015-02-26
Inventor: Jui-Yang Lai , Li-Jyuan Luo , Zih-Han Hong , Kao-Yuan Chang , Po-Cheng Lin , Ming-Hsi Chuang
CPC classification number: C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
Abstract: A hollow particle is provided. The hollow particle of the invention comprises (a) a hollow microparticle, (b) a plural of linking molecules binding the surface of the microparticle, (c) a polypeptide binding the linking molecule, and (d) a target molecule binding the linking molecule. The hollow microparticle of the invention can deliver more cells and provides a higher rate of cell transplantation by the hollow structures, polypeptides and target molecules. The present invention also provides a manufacture of the hollow microparticle and a cell carrier.
Abstract translation: 提供中空颗粒。 本发明的中空颗粒包含(a)中空微粒,(b)多个结合微粒表面的连接分子,(c)与结合分子结合的多肽,和(d)结合连接分子的靶分子 。 本发明的中空微粒可以递送更多的细胞并通过中空结构,多肽和靶分子提供更高的细胞移植速率。 本发明还提供了中空微粒和电池载体的制造。
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公开(公告)号:US09815959B2
公开(公告)日:2017-11-14
申请号:US14632730
申请日:2015-02-26
Inventor: Jui-Yang Lai , Kao-Yuan Chang , Zih-Han Hong , Po-Cheng Lin , Ming-Hsi Chuang
IPC: C08J9/36 , A61K35/35 , A61L27/22 , A61L27/56 , A61L27/58 , A61K35/28 , A61K9/50 , A61L27/16 , A61L27/18 , A61L27/50
CPC classification number: C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
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