公开(公告)号：US20240115616A1

公开(公告)日：2024-04-11

申请号：US18376545

申请日：2023-10-04

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Po-Cheng Lin ,  Pi-Chun Huang ,  Zih-Han Hong ,  Ming-Hsi Chuang ,  Yi-Chun Lin ,  Chia-Hsin Lee ,  Chun-Hung Chen ,  Chao-Liang Chang ,  Kai-Ling Zhang

IPC: A61K35/28 ,  A61K9/00 ,  A61K9/127 ,  A61P1/16 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K9/0019 ,  A61K9/127 ,  A61P1/16 ,  C12N5/0667 ,  C12N2500/02

Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.

公开(公告)号：US09815959B2

公开(公告)日：2017-11-14

申请号：US14632730

申请日：2015-02-26

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Jui-Yang Lai ,  Kao-Yuan Chang ,  Zih-Han Hong ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: C08J9/36 ,  A61K35/35 ,  A61L27/22 ,  A61L27/56 ,  A61L27/58 ,  A61K35/28 ,  A61K9/50 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50

CPC classification number: C08J9/36 ,  A61K9/5031 ,  A61K35/28 ,  A61K35/35 ,  A61L27/16 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/222 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2430/28 ,  C08J2207/10 ,  C08J2367/04 ,  C08J2405/08 ,  C08L67/04 ,  C08L29/04

Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.

公开(公告)号：US20150274923A1

公开(公告)日：2015-10-01

申请号：US14632730

申请日：2015-02-26

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Jui-Yang Lai ,  Kao-Yuan Chang ,  Zih-Han Hong ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: C08J9/36 ,  A61L27/56 ,  A61L27/58 ,  A61L27/22

CPC classification number: C08J9/36 ,  A61K9/5031 ,  A61K35/28 ,  A61K35/35 ,  A61L27/16 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/222 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2430/28 ,  C08J2207/10 ,  C08J2367/04 ,  C08J2405/08 ,  C08L67/04 ,  C08L29/04

Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.

Abstract translation: 提供一种制造中空颗粒的方法。 该方法包括以下步骤：（a）提供中空颗粒; （b）将中空颗粒浸泡在胺溶液中以在中空颗粒的表面上形成胺基; （c）加入多肽，并且多肽与中空颗粒表面上的胺基连接; 和（d）添加目标分子，并且靶分子与尚未结合的胺基结合。

公开(公告)号：US20150238534A1

公开(公告)日：2015-08-27

申请号：US14632760

申请日：2015-02-26

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Jui-Yang Lai ,  Li-Jyuan Luo ,  Zih-Han Hong ,  Kao-Yuan Chang ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: A61K35/35 ,  A61K9/14 ,  C12N11/08

CPC classification number: C08J9/36 ,  A61K9/5031 ,  A61K35/28 ,  A61K35/35 ,  A61L27/16 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/222 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2430/28 ,  C08J2207/10 ,  C08J2367/04 ,  C08J2405/08 ,  C08L67/04 ,  C08L29/04

Abstract: A hollow particle is provided. The hollow particle of the invention comprises (a) a hollow microparticle, (b) a plural of linking molecules binding the surface of the microparticle, (c) a polypeptide binding the linking molecule, and (d) a target molecule binding the linking molecule. The hollow microparticle of the invention can deliver more cells and provides a higher rate of cell transplantation by the hollow structures, polypeptides and target molecules. The present invention also provides a manufacture of the hollow microparticle and a cell carrier.

Abstract translation: 提供中空颗粒。 本发明的中空颗粒包含（a）中空微粒，（b）多个结合微粒表面的连接分子，（c）与结合分子结合的多肽，和（d）结合连接分子的靶分子 。 本发明的中空微粒可以递送更多的细胞并通过中空结构，多肽和靶分子提供更高的细胞移植速率。 本发明还提供了中空微粒和电池载体的制造。