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19 条记录 (耗时 0.048 秒)

    1H-indazole compounds
    2.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07541376B2

    公开(公告)日：2009-06-02

    申请号：US11202234

    申请日：2005-08-12

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/40 ,  C07D231/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compounds
    3.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07776890B2

    公开(公告)日：2010-08-17

    申请号：US12426818

    申请日：2009-04-20

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compound
    4.
    发明授权
    1H-indazole compound 失效
    1H-吲唑化合物

    公开(公告)号：US06982274B2

    公开(公告)日：2006-01-03

    申请号：US10469399

    申请日：2002-04-15

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56 ,  A61P25/00

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R 1是C 6 -C 14芳族环状烃基等; R 2，R 4和R 5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C 1 -C 6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; 和Y是C 3 -C 8环烷基，C 6 -C 14芳族环状烃基 或5〜14元芳香族杂环基等

    Fused indazole compounds
    10.
    发明授权
    Fused indazole compounds 失效
    稠合吲唑化合物

    公开(公告)号：US07390797B2

    公开(公告)日：2008-06-24

    申请号：US10503216

    申请日：2003-02-21

    申请人： Norihito Ohi ,  Nobuaki Sato ,  Naohiro Kohmura

    发明人： Norihito Ohi ,  Nobuaki Sato ,  Naohiro Kohmura

    IPC分类号： A61K31/416 ,  A61K31/4162 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  C07D231/54 ,  C07D245/04 ,  C07D243/10 ,  C07D225/04 ,  C07D223/14 ,  C07D267/04

    CPC分类号： A61K31/55 ,  A61K31/416 ,  A61K31/4439 ,  C07D231/54 ,  C07D401/12 ,  C07D405/12 ,  C07D487/06

    摘要： The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z11 and Z12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2b and R2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新的稠合吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中Z 11和Z 12各自独立地表示羰基，亚甲基等; “img id =”CUSTOM-CHARACTER-00001“he =”2.79mm“wi =”6.35mm“file =”US07390797-20080624-P00001.TIF“alt =”custom character“img-content =”character“img-format =“tif”/>表示双键或单键; R 1a表示氢原子等; 环A表示苯环，萘环或5至10元芳族杂环等; 和R 2a，R 2b和R 2c各自独立地表示（1）氢原子，（2）卤素原子，（3） 硝基等